The DOI matches its Crossref record; 85 of the 85 references it cites were found in a registry or an index.
The phagocyte NOX2 NADPH oxidase in microbial killing and cell signaling
Open accessAbstract
The phagocyte NADPH oxidase possesses a transmembrane electron transferase comprised of gp91phox (aka NOX2) and p22phox and two multicomponent cytosolic complexes, which in stimulated phagocytes translocate to assemble a functional enzyme complex at plasma or phagosomal membranes. The NOX2-centered NADPH oxidase shuttles electrons from cytoplasmic NADPH to molecular oxygen in phagosomes or the extracellular space to produce oxidants that support optimal antimicrobial activity by phagocytes. Additionally, NOX2-generated oxidants have been implicated in both autocrine and paracrine signaling in a variety of biological contexts. However, when interpreting experimental results, investigators must recognize the complexity inherent in the biochemistry of oxidant-mediated attack of microbial targets and the technical limitations of the probes currently used to detect intracellular oxidants.
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“After activation, neutrophils produce more O2•− compared to monocytes and macrophages [178].”
From Superoxide Anion Chemistry—Its Role at the Core of the Innate Immunity (2023) · cites this paper as [178]
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“In neutrophils, H2O2 generation in phagosomes activates the enzyme myeloperoxidase, catalysing the production of HOCl, which is oxidant and antimicrobial, and contributes greatly to the lysis of microbes [178].”
From Superoxide Anion Chemistry—Its Role at the Core of the Innate Immunity (2023) · cites this paper as [178]
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The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology
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Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species
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Cell transformation by the superoxide-generating oxidase Mox1
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Superoxide dismutases and superoxide reductases
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The basics of thiols and cysteines in redox biology and chemistry
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Redox Regulation of NLRP3 Inflammasomes: ROS as Trigger or Effector?
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Reactive Oxygen Species and Neutrophil Function
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Superoxide Anion Chemistry—Its Role at the Core of the Innate Immunity
Andrés, C. M. C., Pérez de la Lastra, J. M., Andrés Juan, C., Plou, F. J., & Pérez-Lebeña, E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24031841 · Cited by 342
Superoxide Radicals in the Execution of Cell Death
Fujii, J., Homma, T., & Osaki, T. (2022) · Antioxidants · doi:10.3390/antiox11030501 · Cited by 337
Macrophage Polarization and Reprogramming in Acute Inflammation: A Redox Perspective
Pérez, S., & Rius-Pérez, S. (2022) · Antioxidants · doi:10.3390/antiox11071394 · Cited by 312
The superoxide radical switch in the biology of nitric oxide and peroxynitrite
Piacenza, L., Zeida, A., Trujillo, M., & Radí, R. (2022) · Physiological Reviews · doi:10.1152/physrev.00005.2022 · Cited by 214
The role of NADPH oxidases in infectious and inflammatory diseases
Taylor, J. P., & Tse, H. M. (2021) · Redox Biology · doi:10.1016/j.redox.2021.102159 · Cited by 185
Metadata
- Authors
- Nauseef, W. M.
- Affiliations
- University of Iowa (US)
- Corresponding author
- Nauseef, William M
- ORCID
- Nauseef, William M
- Venue
- Current Opinion in Immunology
- Publisher
- Elsevier BV
- Published
- 2019-10
- Volume
- 60
- Pages
- 130-140
- ISSN
- 0952-7915 (ISSN-L)
- PMC
- PMC6800624
- OpenAlex
- W2958386701
- Cited by
- 188
- References
- 85
- Citations by year
- 2026: 33 · 2025: 29 · 2024: 27 · 2023: 34 · 2022: 27 · 2021: 20 · 2020: 16 · 2019: 2
- FWCI
- 1.40
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Immunology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Veterans Affairs
- National Institutes of Health (R01-AI116546, R01-AI132335)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Keywords
- NADPH oxidase, gp91phox, p22phox, phagocytes, reactive oxygen species, phagosome, autocrine signaling, paracrine signaling, electron transfer
- MeSH terms
- NADPH Oxidase 2, Animals, Granulomatous Disease, Chronic, Humans, Hydrogen Peroxide, Neutrophils, Oxidation-Reduction, Phagocytes, Phagocytosis, Phagosomes, Signal Transduction, Oxidants
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