Tissue-resident CD8 T cells in central nervous system inflammatory diseases: present at the crime scene and …guilty
Open accessAbstract
Tissue-resident memory T cells (TRM) represent a subset of antigen-experienced T cells that are constantly retained in a given tissue with limited trafficking through the circulation. These cells are characterized by expression of molecules enabling their tissue anchoring and downregulation of molecules promoting tissue egress. They reside at sites of previous antigen encounter and their number increases with age. TRM have been shown to provide rapid and efficient protection against tissue reinfection and TRM density correlates with efficient antitumor responses. Intriguingly, the density of CD8 TRM is increased in the central nervous system (CNS) of patients with neuroinflammatory diseases such as multiple sclerosis, or suffering from neurodegenerative diseases. In this review, we discuss current knowledge regarding the diversity of CNS-resident CD8 T cells and their role in CNS autoimmunity. Given their likely contribution to the protracted course of several inflammatory diseases of the CNS, their therapeutic targeting becomes an important challenge.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In organs other than the heart, TRM cells have been incriminated as key drivers of autoimmune diseases including psoriasis, vitiligo, type 1 diabetes, idiopathic arthritis, Alzheimer disease, and multiple sclerosis.
“Moreover, in other organs than the heart, T RM cells have been incriminated as key drivers of autoimmune diseases including psoriasis, vitiligo, type 1 diabetes, idiopathic arthritis, Alzheimer disease, and multiple sclerosis. 294,302-310”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [308]
The section on chronic CNS inflammatory disease reports TRM cells in multiple sclerosis and Alzheimer disease and describes ways they may contribute to CNS damage. It does not establish them as key drivers of either disease, and it describes Alzheimer disease as neurodegenerative rather than autoimmune. The passages do not address psoriasis, vitiligo, type 1 diabetes, or idiopathic arthritis. (LLM, conf=0.88)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility
International Multiple Sclerosis Genetics Consortium, Patsopoulos, N. A., Baranzini, S. E., Santaniello, A., Shoostari, P., Cotsapas, C., Wong, G., Beecham, A. H., James, T., Replogle, J., et al. (2019) · Science · doi:10.1126/science.aav7188 · Cited by 1,471 · see citing works
The developmental pathway for CD103+CD8+ tissue-resident memory T cells of skin
Mackay, L. K., Rahimpour, A., Ma, J. Z., Collins, N., Stock, A. T., Hafon, M.-L., Vega-Ramos, J., Lauzurica, P., Mueller, S. N., Stefanovic, T., et al. (2013) · Nature Immunology · doi:10.1038/ni.2744 · Cited by 1,331 · see citing works
Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes
Mackay, L. K., Minnich, M., Kragten, N. A. M., Liao, Y., Nota, B., Seillet, C., Zaid, A., Man, K., Preston, S., Freestone, D., et al. (2016) · Science · doi:10.1126/science.aad2035 · Cited by 1,010 · see citing works
Skon, C. N., Lee, J.-Y., Anderson, K. G., Masopust, D., Hogquist, K. A., & Jameson, S. C. (2013) · Nature Immunology · doi:10.1038/ni.2745 · Cited by 817 · see citing works
Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism
Pan, Y., Tian, T., Park, C. O., Lofftus, S. Y., Mei, S., Liu, X., Luo, C., O’Malley, J. T., Gehad, A. E., Teague, J. E., et al. (2017) · Nature · doi:10.1038/nature21379 · Cited by 718 · see citing works
Runx3 programs CD8+ T cell residency in non-lymphoid tissues and tumours
Milner, J. J., Toma, C., Yu, B., Zhang, K., Omilusik, K., Phan, A. T., Wang, D., Getzler, A. J., Nguyen, T., Crotty, S., et al. (2017) · Nature · doi:10.1038/nature24993 · Cited by 677 · see citing works
Sensing and alarm function of resident memory CD8+ T cells
Schenkel, J., Fraser, K. A., Vezys, V., & Masopust, D. (2013) · Nature Immunology · doi:10.1038/ni.2568 · Cited by 648 · see citing works
Djenidi, F., Adam, J., Goubar, A., Durgeau, A., Meurice, G., de Montpréville, V., Validire, P., Besse, B., & Mami-Chouaib, F. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402711 · Cited by 622 · see citing works
Mackay, L. K., Wynne-Jones, E., Freestone, D., Pellicci, D. G., Mielke, L. A., Newman, D. M., Braun, A., Masson, F., Kallies, A., Belz, G. T., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.11.008 · Cited by 597 · see citing works
Self-citationWakim, L. M., Davis, A. S. W., & Bevan, M. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010201107 · Cited by 577 · see citing works
Machado-Santos, J., Saji, E., Tröscher, A. R., Paunovic, M., Liblau, R., Gabriely, G., Bien, C. G., Bauer, J., & Lassmann, H. (2018) · Brain · doi:10.1093/brain/awy151 · Cited by 548 · see citing works
Self-citationTranscriptional programs of neoantigen-specific TIL in anti-PD-1-treated lung cancers
Caushi, J. X., Zhang, J., Ji, Z., Vaghasia, A. M., Zhang, B., Hsiue, E. H.-C., Mog, B. J., Hou, W., Justesen, S. F. L., Blosser, R. L., et al. (2021) · Nature · doi:10.1038/s41586-021-03752-4 · Cited by 539 · see citing works
Skin-resident memory CD8 + T cells trigger a state of tissue-wide pathogen alert
Ariotti, S., Hogenbirk, M. A., Dijkgraaf, F. E., Visser, L. L., Hoekstra, M. E., Song, J., Jacobs, H., Haanen, J. B. A. G., & Schumacher, T. N. (2014) · Science · doi:10.1126/science.1254803 · Cited by 534 · see citing works
Single-cell analysis reveals T cell infiltration in old neurogenic niches
Dulken, B. W., Buckley, M. T., Navarro Negredo, P., Saligrama, N., Cayrol, R., Leeman, D. S., George, B. M., Boutet, S. C., Hebestreit, K., Pluvinage, J. V., et al. (2019) · Nature · doi:10.1038/s41586-019-1362-5 · Cited by 521 · see citing works
Mackay, L. K., Braun, A., Macleod, B. L., Collins, N., Tebartz, C., Bedoui, S., Carbone, F. R., & Gebhardt, T. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402256 · Cited by 503 · see citing works
Programs for the persistence, vigilance and control of human CD8+ lung-resident memory T cells
Hombrink, P., Helbig, C., Backer, R. A., Piet, B., Oja, A. E., Stark, R., Brasser, G., Jongejan, A., Jonkers, R. E., Nota, B., et al. (2016) · Nature Immunology · doi:10.1038/ni.3589 · Cited by 455 · see citing works
Webb, J. R., Milne, K., Watson, P. H., deLeeuw, R. J., & Nelson, B. H. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-1877 · Cited by 435 · see citing works
Edwards, J. J., Wilmott, J. S., Madore, J., Gide, T. N., Quek, C. Y. J., Tasker, A. T., Ferguson, A. L., Chen, J., Hewavisenti, R., Hersey, P., et al. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-2257 · Cited by 431 · see citing works
Tissue-resident memory T cells populate the human brain
Smolders, J., Heutinck, K. M., Fransen, N. L., Remmerswaal, E. B. M., Hombrink, P., ten Berge, I. J. M., van Lier, R. A. W., Huitinga, I., & Hamann, J. (2018) · Nature Communications · doi:10.1038/s41467-018-07053-9 · Cited by 406 · see citing works
Zhang, N., & Bevan, M. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.019 · Cited by 403 · see citing works
Herndler-Brandstetter, D., Ishigame, H., Shinnakasu, R., Plajer, V., Stecher, C., Zhao, J., Lietzenmayer, M., Kroehling, L., Takumi, A., Kometani, K., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.03.015 · Cited by 382 · see citing works
Tissue-resident memory CD8+ T cells promote melanoma–immune equilibrium in skin
Park, S. L., Buzzai, A. C., Rautela, J., Hor, J. L., Hochheiser, K., Effern, M., McBain, N., Wagner, T., Edwards, J. J., McConville, R., et al. (2018) · Nature · doi:10.1038/s41586-018-0812-9 · Cited by 378 · see citing works
Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition
Pasciuto, E., Burton, O. T., Roca, C. P., Lagou, V., Rajan, W. D., Theys, T., Mancuso, R., Tito, R. Y., Kouser, L., Callaerts-Vegh, Z., et al. (2020) · Cell · doi:10.1016/j.cell.2020.06.026 · Cited by 368 · see citing works
The Molecular Signature of Tissue Resident Memory CD8 T Cells Isolated from the Brain
Wakim, L. M., Davis, A. S. W., Liu, R., Hu, Y., Villadangos, J. A., Smyth, G. K., & Bevan, M. J. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1201305 · Cited by 365 · see citing works
Resident memory T cells, critical components in tumor immunology
Mami‐Chouaib, F., Blanc, C., Corgnac, S., Hans, S., Malenica, I., Granier, C., Tihy, I., & Tartour, É. (2018) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-018-0399-6 · Cited by 328 · see citing works
Hair follicle–derived IL-7 and IL-15 mediate skin-resident memory T cell homeostasis and lymphoma
Adachi, T., Kobayashi, T., Sugihara, E., Yamada, T., Ikuta, K., Pittaluga, S., Saya, H., Amagai, M., & Nagao, K. (2015) · Nature Medicine · doi:10.1038/nm.3962 · Cited by 326 · see citing works
Common clonal origin of central and resident memory T cells following skin immunization
Gaide, O., Emerson, R., Jiang, X., Gulati, N., Nizza, S. T., Desmarais, C., Robins, H. S., Krueger, J. G., Clark, R. A., & Kupper, T. S. (2015) · Nature Medicine · doi:10.1038/nm.3860 · Cited by 290 · see citing works
Garber, C., Soung, A., Vollmer, L. L., Kanmogne, M., Last, A., Brown, J., & Klein, R. S. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0427-y · Cited by 272 · see citing works
Milner, J. J., Toma, C., He, Z., Kurd, N. S., Nguyen, Q., McDonald, B., Quezada, L. K., Widjaja, C. E., Witherden, D. A., Crowl, J. T., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.04.007 · Cited by 271 · see citing works
CD8 T cell nigral infiltration precedes synucleinopathy in early stages of Parkinson's disease
Galiano-Landeira, J., Torra, A., Vila, M., & Bové, J. (2020) · Brain · doi:10.1093/brain/awaa269 · Cited by 267 · see citing works
T Cells in Nonlymphoid Tissues Give Rise to Lymph-Node-Resident Memory T Cells
Beura, L. K., Wijeyesinghe, S., Thompson, E. A., Macchietto, M. G., Rosato, P. C., Pierson, M. J., Schenkel, J. M., Mitchell, J. S., Vezys, V., Fife, B. T., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.01.015 · Cited by 262 · see citing works
Li, C., Zhu, B., Son, Y. M., Wang, Z., Jiang, L., Xiang, M., Ye, Z., Beckermann, K. E., Wu, Y., Jenkins, J. W., et al. (2019) · Immunity · doi:10.1016/j.immuni.2019.08.013 · Cited by 244 · see citing works
The precursors of CD8+ tissue resident memory T cells: from lymphoid organs to infected tissues
Kok, L., Masopust, D., & Schumacher, T. N. (2022) · Nature Reviews Immunology · doi:10.1038/s41577-021-00590-3 · Cited by 230 · see citing works
Fransen, N. L., Hsiao, C., van der Poel, M., Engelenburg, H. J., Verdaasdonk, K., Vincenten, M. C. J., Remmerswaal, E. B. M., Kuhlmann, T., Mason, M. R. J., Hamann, J., et al. (2020) · Brain · doi:10.1093/brain/awaa117 · Cited by 227 · see citing works
Brain-resident memory T cells represent an autonomous cytotoxic barrier to viral infection
Steinbach, K., Vincenti, I., Kreutzfeldt, M., Pagé, N., Muschaweckh, A., Wagner, I., Drexler, I., Pinschewer, D. D., Korn, T., & Merkler, D. (2016) · The Journal of Experimental Medicine · doi:10.1084/jem.20151916 · Cited by 212 · see citing works
Self-citationKurd, N. S., He, Z., Louis, T. L., Milner, J. J., Omilusik, K. D., Jin, W., Tsai, M. S., Widjaja, C. E., Kanbar, J. N., Olvera, J. G., et al. (2020) · Science Immunology · doi:10.1126/sciimmunol.aaz6894 · Cited by 209 · see citing works
CD4 + T cells contribute to neurodegeneration in Lewy body dementia
Gate, D., Tapp, E., Leventhal, O., Shahid, M., Nonninger, T. J., Yang, A. C., Strempfl, K., Unger, M. S., Fehlmann, T., Oh, H. S., et al. (2021) · Science · doi:10.1126/science.abf7266 · Cited by 209 · see citing works
Neurons under T Cell Attack Coordinate Phagocyte-Mediated Synaptic Stripping
Di Liberto, G., Pantelyushin, S., Kreutzfeldt, M., Page, N., Musardo, S., Coras, R., Steinbach, K., Vincenti, I., Klimek, B., Lingner, T., et al. (2018) · Cell · doi:10.1016/j.cell.2018.07.049 · Cited by 195 · see citing works
Self-citationTissue-resident memory CD8+ T cells shape local and systemic secondary T cell responses
Behr, F. M., Parga-Vidal, L., Kragten, N. A. M., van Dam, T. J. P., Wesselink, T. H., Sheridan, B. S., Arens, R., van Lier, R. A. W., Stark, R., & van Gisbergen, K. P. J. M. (2020) · Nature Immunology · doi:10.1038/s41590-020-0723-4 · Cited by 184 · see citing works
Ritzel, R. M., Crapser, J. D., Patel, A. R., Verma, R., Grenier, J. M., Chauhan, A., Jellison, E. R., & McCullough, L. D. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1502021 · Cited by 182 · see citing works
Komdeur, F. L., Prins, T. M., van de Wall, S., Plat, A., Wisman, G. B. A., Hollema, H., Daemen, T., Church, D. N., de Bruyn, M., & Nijman, H. W. (2017) · OncoImmunology · doi:10.1080/2162402x.2017.1338230 · Cited by 168 · see citing works
Wang, B., Wu, S., Zeng, H., Liu, Z., Dong, W., He, W., Chen, X., Dong, X., Zheng, L., Lin, T., et al. (2015) · The Journal of Urology · doi:10.1016/j.juro.2015.02.2941 · Cited by 166 · see citing works
Tissue-resident CD8 + T cells drive age-associated chronic lung sequelae after viral pneumonia
Goplen, N. P., Wu, Y., Son, Y. M., Li, C., Wang, Z., Cheon, I. S., Jiang, L., Zhu, B., Ayasoufi, K., Chini, E. N., et al. (2020) · Science Immunology · doi:10.1126/sciimmunol.abc4557 · Cited by 151 · see citing works
PD-1 hi CD8 + resident memory T cells balance immunity and fibrotic sequelae
Wang, Z., Wang, S., Goplen, N. P., Li, C., Cheon, I. S., Dai, Q., Huang, S., Shan, J., Ma, C., Ye, Z., et al. (2019) · Science Immunology · doi:10.1126/sciimmunol.aaw1217 · Cited by 136 · see citing works
Transcriptomic and clonal characterization of T cells in the human central nervous system
Pappalardo, J. L., Zhang, L., Pecsok, M. K., Perlman, K., Zografou, C., Raddassi, K., Abulaban, A. A., Krishnaswamy, S., Antel, J. P., van Dijk, D., et al. (2020) · Science Immunology · doi:10.1126/sciimmunol.abb8786 · Cited by 132 · see citing works
Organ-specific isoform selection of fatty acid–binding proteins in tissue-resident lymphocytes
Frizzell, H., Fonseca, R., Christo, S., Evrard, M., Cruz-Gomez, S., Zanluqui, N., von Scheidt, B., Freestone, D., Park, S. L., McWilliam, H., et al. (2020) · Science immunology · doi:10.1126/sciimmunol.aay9283 · Cited by 122 · see citing works
Urban, S. L., Jensen, I. J., Shan, Q., Pewe, L. L., Xue, H., Badovinac, V. P., & Harty, J. T. (2020) · Nature Immunology · doi:10.1038/s41590-020-0711-8 · Cited by 120 · see citing works
Early adaptive immune activation detected in monozygotic twins with prodromal multiple sclerosis
Beltrán, E., Gerdes, L. A., Hansen, J., Flierl‐Hecht, A., Krebs, S., Blum, H., Ertl-Wagner, B. B., Barkhof, F., Kümpfel, T., Hohlfeld, R., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci128475 · Cited by 119 · see citing works
Low, J. S., Farsakoglu, Y., Vesely, M. C. A., Sefik, E., Kelly, J. B., Harman, C. C. D., Jackson, R. P., Shyer, J. A., Jiang, X., Cauley, L. S., et al. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20192291 · Cited by 117 · see citing works
Peng, C., Huggins, M. A., Wanhainen, K. M., Knutson, T. P., Lu, H., Georgiev, H., Mittelsteadt, K. L., Jarjour, N. N., Wang, H., Hogquist, K. A., et al. (2021) · Immunity · doi:10.1016/j.immuni.2021.11.017 · Cited by 116 · see citing works
Evrard, M., Wynne-Jones, E., Peng, C., Kato, Y., Christo, S. N., Fonseca, R., Park, S. L., Burn, T. N., Osman, M., Devi, S., et al. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20210116 · Cited by 115 · see citing works
A committed tissue-resident memory T cell precursor within the circulating CD8+ effector T cell pool
Kok, L., Dijkgraaf, F. E., Urbanus, J. H. M., Bresser, K., Vredevoogd, D. W., Cardoso, R. F., Perié, L., Beltman, J. B., & Schumacher, T. N. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20191711 · Cited by 114 · see citing works
Masson, F., Calzascia, T., Berardino-Besson, W. D., de Tribolet, N., Dietrich, P., & Walker, P. R. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.2.845 · Cited by 113 · see citing works
Self-citationRegulatory T cells shape the resident memory T cell response to virus infection in the tissues.
Graham, J. B., da Costa, A. D., & Lund, J. M. (2013) · Journal of Immunology · doi:10.4049/jimmunol.1202153 · Cited by 110 · see citing works
Frieser, D., Pignata, A., Khajavi, L., Shlesinger, D., Gonzalez-Fierro, C., Nguyen, X.-H., Yermanos, A., Merkler, D., Höftberger, R., Desestret, V., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abl6157 · Cited by 102 · see citing works
Self-citationHobit identifies tissue-resident memory T cell precursors that are regulated by Eomes
Parga-Vidal, L., Behr, F. M., Kragten, N., Nota, B., Wesselink, T. H., Kavazović, I., Covill, L., Schüller, M., Bryceson, Y., Wensveen, F. M., et al. (2021) · Science immunology · doi:10.1126/sciimmunol.abg3533 · Cited by 82 · see citing works
Cutting Edge: Resident Memory CD8 T Cells Express High-Affinity TCRs
Frost, E. L., Kersh, A. E., Evavold, B. D., & Lukacher, A. E. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1501521 · Cited by 80 · see citing works
Ogino, H., Taylor, J. W., Nejo, T., Gibson, D., Watchmaker, P. B., Okada, K., Saijo, A., Tedesco, M. R., Shai, A., Wong, C. M., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci151239 · Cited by 76 · see citing works
Vincenti, I., Page, N., Steinbach, K., Yermanos, A., Lemeille, S., Nunez, N., Kreutzfeldt, M., Klimek, B., Di Liberto, G., Egervari, K., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abl6058 · Cited by 70 · see citing works
Self-citationBrain-resident memory T cells generated early in life predispose to autoimmune disease in mice
Steinbach, K., Vincenti, I., Egervari, K. L., Kreutzfeldt, M., van der Meer, F., Pagé, N., Klimek, B., Rossitto-Borlat, I., Liberto, G. D., Muschaweckh, A., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aav5519 · Cited by 68 · see citing works
Self-citationPrasad, S., Hu, S., Sheng, W. S., Chauhan, P., Singh, A. R., & Lokensgard, J. R. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0860-3 · Cited by 64 · see citing works
Ren, H. M., Kolawole, E. M., Ren, M., Jin, G., Netherby, C. S., Wade, Q. W., Shwetank, Rahman, Z. S. M., Evavold, B. D., & Lukacher, A. E. (2020) · Science Immunology · doi:10.1126/sciimmunol.abb5590 · Cited by 64 · see citing works
Durrant, D. M., Daniels, B. P., & Klein, R. S. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1401192 · Cited by 63 · see citing works
Landrith, T. A., Sureshchandra, S., Rivera, A., Jang, J. C., Rais, M., Nair, M. G., Messaoudi, I., & Wilson, E. H. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00335 · Cited by 62 · see citing works
Hasan, F., Chiu, Y., Shaw, R., Wang, J., & Yee, C. (2021) · JCI Insight · doi:10.1172/jci.insight.138970 · Cited by 56 · see citing works
Ogino, H., Taylor, J. W., Nejo, T., Gibson, D., Watchmaker, P. B., Okada, K., Saijo, A., Tedesco, M., Shai, A., Wong, C. M., et al. (2022) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 55 · see citing works
Shwetank, Frost, E. L., Mockus, T. E., Ren, H. M., Toprak, M., Lauver, M. D., Netherby, C. S., Jin, G., Cosby, J., Evavold, B. D., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00783 · Cited by 47 · see citing works
Functional virus-specific memory T cells survey glioblastoma
Ning, J., Gavil, N. V., Wu, S., Wijeyesinghe, S., Weyu, E., Ma, J., Li, M., Grigore, F.-N., Dhawan, S., Skorput, A. G. J., et al. (2022) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-021-03125-w · Cited by 46 · see citing works
Evidence for Resident Memory T Cells in Rasmussen Encephalitis
Owens, G. C., Chang, J. W., Huynh, M. N., Chirwa, T. W., Vinters, H. V., & Mathern, G. W. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00064 · Cited by 42 · see citing works
Mockus, T. E., Shwetank, Lauver, M. D., Ren, H. M., Netherby, C. S., Salameh, T. J., Kawasawa, Y. I., Yue, F., Broach, J. R., & Lukacher, A. E. (2018) · PLoS Pathogens · doi:10.1371/journal.ppat.1007365 · Cited by 38 · see citing works
SOX2 immunity and tissue resident memory in children and young adults with glioma
Vasquez, J. C., Huttner, A. J., Zhang, L., Marks, A. M., Chan, A., Baehring, J. M., Kahle, K. T., & Dhodapkar, K. M. (2017) · Journal of Neuro-Oncology · doi:10.1007/s11060-017-2515-8 · Cited by 36 · see citing works
Bernard‐Valnet, R., Frieser, D., Nguyen, X., Khajavi, L., Queriault, C., Arthaud, S., Melzi, S., Fusade-Boyer, M., Masson, F., Zytnicki, M., et al. (2021) · Brain · doi:10.1093/brain/awab455 · Cited by 32 · see citing works
Self-citationMcLaren, J. E., Clement, M., Marsden, M., Miners, K. L., Llewellyn‐Lacey, S., Grant, E. J., Rubina, A., Brias, S. G., Emma Gostick, D., Stacey, M. A., et al. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1701757 · Cited by 28 · see citing works
Cassidy, B. R., Zhang, M., Sonntag, W. E., & Drevets, D. A. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01929-8 · Cited by 27 · see citing works
Prasad, S., Hu, S., Sheng, W. S., Chauhan, P., & Lokensgard, J. R. (2018) · Immunity Inflammation and Disease · doi:10.1002/iid3.221 · Cited by 23 · see citing works
Local Antigen Encounter Is Essential for Establishing Persistent CD8+ T-Cell Memory in the CNS
Schøller, A. S., Fonnes, M. K., Nazerai, L., Christensen, J. P., & Thomsen, A. R. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00351 · Cited by 23 · see citing works
Fundamental mechanistic insights from rare but paradigmatic neuroimmunological diseases
Wiendl, H., Groß, C. C., Bauer, J., Merkler, D., Prat, A., & Liblau, R. (2021) · Nature Reviews Neurology · doi:10.1038/s41582-021-00496-7 · Cited by 18 · see citing works
Self-citationChang, J. W., Reyes, S. D., Faure-Kumar, E., Lam, S. K., Lawlor, M. W., Leventer, R. J., Lew, S. M., Lockhart, P. J., Pope, K., Weiner, H. L., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.664344 · Cited by 16 · see citing works
Garcia, S. A., Lebrun, A., Kean, R. B., & Hooper, D. C. (2018) · Journal of NeuroVirology · doi:10.1007/s13365-018-0655-z · Cited by 9 · see citing works
Lebrun, A., Kean, R. B., & Hooper, D. C. (2020) · Future Virology · doi:10.2217/fvl-2020-0132 · Cited by 8 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- and recommended reading Papers of particular interest, published within the period of review, have been highlighted as: •• of special interest •• of outstanding interest
Cited by
Sorted by citations
White matter aging and its impact on brain function
Groh, J., & Simons, M. (2025) · Neuron · doi:10.1016/j.neuron.2024.10.019 · Cited by 124 · see citing works
Groh, J., Feng, R., Yuan, X., Liu, L., Klein, D., Hutahaean, G., Butz, E. S., Wang, Z., Steinbrecher, L., Neher, J. J., et al. (2025) · Nature Neuroscience · doi:10.1038/s41593-025-01955-w · Cited by 73 · see citing works
Immune mechanisms and shared immune targets in neurodegenerative diseases
Weiner, H. L. (2024) · Nature Reviews Neurology · doi:10.1038/s41582-024-01046-7 · Cited by 63 · see citing works
Targeting cytokine networks in neuroinflammatory diseases
Becher, B., Derfuss, T. J., & Liblau, R. (2024) · Nature Reviews Drug Discovery · doi:10.1038/s41573-024-01026-y · Cited by 53 · see citing works
Self-citationAutoimmune Myocarditis, Old Dogs and New Tricks.
Won, T., Song, E. J., Kalinoski, H. M., Moslehi, J. J., & Čiháková, D. (2024) · Circulation Research · doi:10.1161/circresaha.124.323816 · Cited by 51 · see citing works
The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis
Woo, M. S., Brand, J., Bal, L. C., Moritz, M., Walkenhorst, M., Vieira, V., Ipenberg, I., Rothammer, N., Wang, M., Dogan, B., et al. (2025) · Cell · doi:10.1016/j.cell.2025.05.029 · Cited by 46 · see citing works
Self-citationFeng, R., Spieth, L., Liu, L., Berghoff, S. A., Franz, J., Liu, Q., Wang, Z., Tiwari, V., Vitale, S., Frerich, S., et al. (2025) · Immunity · doi:10.1016/j.immuni.2025.10.003 · Cited by 36 · see citing works
Lipid metabolism and neuroinflammation: What is the link?
Tiwari, V., & Simons, M. (2025) · The Journal of Experimental Medicine · doi:10.1084/jem.20241232 · Cited by 34 · see citing works
Serafini, B., Rosicarelli, B., Veroni, C., & Aloisi, F. (2023) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2023.578036 · Cited by 28 · see citing works
The role of the adaptive immune system in the initiation and persistence of multiple sclerosis
Afzali, A. M., & Korn, T. (2025) · Seminars in Immunology · doi:10.1016/j.smim.2025.101947 · Cited by 25 · see citing works
Pignata, A., Frieser, D., Gonzalez-Fierro, C., Hsiao, C.-C., Engelenburg, H. J., Alis, M., Fijalkow, I., Cazaentre, V., Nozeran, L., Miranda-Capet, R., et al. (2025) · Science Translational Medicine · doi:10.1126/scitranslmed.adp8109 · Cited by 24 · see citing works
Self-citationTissue‐resident memory T cells in diseases and therapeutic strategies
Xie, D., Lu, G., Mai, G., Guo, Q., & Xu, G. (2025) · MedComm · doi:10.1002/mco2.70053 · Cited by 18 · see citing works
Autoimmune-associated epilepsy – a challenging concept
Melzer, N., & Rosenow, F. (2024) · Seizure · doi:10.1016/j.seizure.2024.05.017 · Cited by 14 · see citing works
Targeted Therapy of Multiple Sclerosis: A Case for Antigen-Specific Tregs
Stauss, H. J., & Zhong, Y. (2024) · Cells · doi:10.3390/cells13100797 · Cited by 12 · see citing works
Blant, J. C., Rossi, N. D., Gold, R., Maurousset, A., Kraemer, M., Romero-Pinel, L., Misu, T., Ouallet, J., Pallix-Guyot, M., Gerevini, S., et al. (2024) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000200281 · Cited by 7 · see citing works
Freeman, S. A., Ayoub, I., Dauvilliers, Y. A., & Liblau, R. (2025) · Seminars in Immunology · doi:10.1016/j.smim.2025.101962 · Cited by 6 · see citing works
Self-citationTissue resident memory T cells populate the human uveal tract
Foers, A. D., Reekie, I. R., Wickramasinghe, L. C., Ward, A., Buckley, T. M. W., Attar, M., Aguilar-Munoa, S., Pilapil, Q., Elsayed, M. E. A. A., Pledger, S., et al. (2026) · Scientific Reports · doi:10.1038/s41598-025-33444-2 · Cited by 6 · see citing works
Coulibaly, A. S. K., Nozeran, L., Thomann, C., Alis, M., Bassot, E., Hassan, A., Porte, R., Belloy, M., Blanchard, N., & Masson, F. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115861 · Cited by 6 · see citing works
Self-citationCassidy, B., Logan, S., Farley, J. A., Owen, D. B., Sonntag, W., & Drevets, D. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1146690 · Cited by 5 · see citing works
In silico transcriptomic analysis for biomarker discovery in TB and HIV co-infection
Aalam, J., & Parveen, R. (2026) · Computational Biology and Chemistry · doi:10.1016/j.compbiolchem.2026.108954 · Cited by 3 · see citing works
Host–virus determinants of Ebola virus persistence in a human cerebral organoid model
Widerspick, L., Vidal-Freire, S., Steffen, J. F., Shirsathe, S., Allartz, P., Vickers, M. A., Henkel, C., Neira-Pelén, P., Nave, J., Rottstegge, M., et al. (2026) · Nature Microbiology · doi:10.1038/s41564-026-02388-2 · Cited by 3 · see citing works
Multifaceted functions of tissue-resident memory T cells in tumorigenesis and cancer immunotherapy
Seo, E. S., Lee, S., & Son, Y. M. (2025) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-025-04035-x · Cited by 3 · see citing works
The T Cell Response to Epstein-Barr Virus
Long, H. M., & Taylor, G. S. (2026) · Current topics in microbiology and immunology · doi:10.1007/82_2025_339 · Cited by 3 · see citing works
Huang, X. H., Zhong, Y., Li, H., Wu, L., Li, Y., Wang, R., Qiao, X., Han, Y., Zhang, H., Liu, D., et al. (2025) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2025.104737 · Cited by 1 · see citing works
Korn, T. (2024) · Elsevier eBooks · doi:10.1016/b978-0-12-823848-6.00004-x · Cited by 1 · see citing works
Liblau, R. (2025) · Bulletin de l Académie Nationale de Médecine · doi:10.1016/j.banm.2024.11.026
Self-citationWilke, J. B. H., Ntolkeras, A., Gastaldi, V. D., Borowski, K., Teegen, B., STÖCKER, W., Lühder, F., Nave, K., & Ehrenreich, H. (2025) · Scientific Reports · doi:10.1038/s41598-025-08035-w
Li, X., Sun, X., Hao, S., Wang, G., Guo, Y., He, Y., Zhang, Q., Feng, Z., Wang, G., & Liu, C. (2025) · Immunity Inflammation and Disease · doi:10.1002/iid3.70287
Role of T-cell immunity in the pathophysiology of Alzheimer’s disease and other Tauopathies
Matta, K. (2024) · theses.fr (ABES) · doi:10.70675/cea4fe5ez67c3z4445z92f7z39af62ba059b
Wu, D., Zhang, S., Jamal, Y. A., Sarkar, T. T., Tomczak, A. J., Sumera, J., Oak, J. S., Melamed, E., Nie, E. H., Galetta, K. M., et al. (2026) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlag050
- Authors
- Merkler, D., Vincenti, I., Masson, F., & Liblau, R. S.
- Affiliations
- University of Geneva (CH)
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Merkler, Doron
- Venue
- Current Opinion in Immunology
- Publisher
- Elsevier BV
- Published
- 2022-08
- Volume
- 77
- Pages
- 102211
- ISSN
- 0952-7915 (ISSN-L)
- OpenAlex
- W4281664196
- Cited by
- 30
- References
- 80
- Citations by year
- 2026: 5 · 2025: 14 · 2024: 9 · 2023: 2
- FWCI
- 0.66
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Current Opinion in Immunology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (publishedVersion, other-oa)
- HAL (submittedVersion, cc-by-nc-nd)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by-nc-nd)
- Funders
- European Research Council (865026)
- Agence Nationale de la Recherche (CE17-0014)
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Fondation pour l'Aide à la Recherche sur la Sclérose en Plaques (RHU-18-0012)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- tissue-resident memory T cells, CD8+ T cells, central nervous system, neuroinflammation, multiple sclerosis, neurodegenerative diseases, central nervous system autoimmunity, T cell migration, therapeutic targeting
- MeSH terms
- Antigens, Central Nervous System, Crime, Humans, Immunologic Memory, CD8-Positive T-Lymphocytes
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
