Composite microparticle drug delivery systems based on chitosan, alginate and pectin with improved pH-sensitive drug release property
Abstract
Composite microparticle drug delivery systems based on chitosan, alginate and pectin with improved pH sensitivity were developed for oral delivery of protein drugs, using bovine serum albumin (BSA) as a model drug. The composite drug-loaded microparticles with a mean particle size less than 200mum were prepared by a convenient shredding method. Since the microparticles were formed by tripolyphosphate cross-linking, electrostatic complexation by alginate and/or pectin, as well as ionotropic gelation with calcium ions, the microparticles exhibited an improved pH-sensitive drug release property. The in vitro drug release behaviors of the microparticles were studied in simulated gastric (pH 1.2 and pH 5.0), intestinal (pH 7.4) and colonic (pH 6.0 and pH 6.8 with enzyme) media. For the composite microparticles with suitable compositions, the releases of BSA at pH 1.2 and pH 5.0 could be effectively sustained, while the releases at pH 7.4, pH 6.8 and pH 6.0 increased significantly, especially in the presence of pectinase. These results clearly suggested that the microparticles had potential for site-specific protein drug delivery through oral administration.
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Natural polymers are generally of low price, biodegradable, biocompatible and nontoxic, in contrast to synthetic polymers.
“In contrast to synthetic polymers, natural polymers are generally of low price, biodegradable, biocompatible and nontoxic.”
A similar increase in swelling has previously been reported by Pourjavadi & Barzegar and Yu et al.
“Similar increase in the swelling has previoulsy reported by Pourjavadi & Barzegar and Yu et al.21,48”
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- Authors
- Yu, C.-Y., Yin, B.-C., Zhang, W., Cheng, S.-X., Zhang, X.-Z., & Zhuo, R.-X.
- Affiliations
- Wuhan University (CN)
- Corresponding author
- Cheng, Si-Xue
- Venue
- Colloids and Surfaces B: Biointerfaces
- Publisher
- Elsevier BV
- Published
- 2009-02
- Volume
- 68
- Issue
- 2
- Pages
- 245-249
- ISSN
- 0927-7765 (ISSN-L)
- OpenAlex
- W2025864326
- Cited by
- 190
- References
- 22
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 12 · 2023: 4 · 2022: 7 · 2021: 15 · 2020: 13 · 2019: 19 · 2018: 11 · 2017: 20 · 2016: 17 · 2015: 7 · 2014: 13 · 2013: 11 · 2012: 13
- FWCI
- 4.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Colloids and Surfaces B Biointerfaces (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Science and Technology of the People's Republic of China (2005CB623903)
- National Natural Science Foundation of China (20774070)
- Ministry of Education of the People's Republic of China (707043)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Agricultural and Biological Sciences › Food Science › Microencapsulation and Drying Processes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Keywords
- composite microparticles, chitosan, alginate, pectin, pH-responsive drug release, bovine serum albumin, sodium tripolyphosphate crosslinking, ionic gelation, electrostatic complexation, local drug delivery, pectinase
- MeSH terms
- Alginates, Animals, Cattle, Hexuronic Acids, Hydrogen-Ion Concentration, Particle Size, Pectins, Polygalacturonase, Serum Albumin, Bovine, Drug Delivery Systems, Glucuronic Acid, Chitosan, Nanoparticles, Nanocomposites
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