Improved endothelialization of NiTi alloy by VEGF functionalized nanocoating
Abstract
To improve surface endothelialization of NiTi alloy substrate, a nano-structured coating functionalized with vascular endothelial growth factor (VEGF) was fabricated via polydopamine (PDOP) as intermediate layer. The successful preparation of VEGF conjugated nanocoating was demonstrated by X-ray diffraction (XRD), atomic force microscope (AFM), scanning electron microscopy (SEM), and X-ray photoelectron spectroscopy (XPS), respectively. Inductively coupled plasma mass spectrometry (ICP-MS) test showed that the formed nanocoating significantly reduced the release of Ni ion from NiTi alloy in simulated body fluid. The biological behaviors of endothelial cells adhered to modified NiTi alloy substrates, including cell proliferation, cell spreading and production of nitric oxide and prostacyclin were investigated in vitro. The results suggest that surface functionalization of NiTi alloy substrate with VEGF is beneficial for cell growth. The approach presented here affords an alternative for surface modification of NiTi implants applied as heart and vascular implant devices.
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PDA-assisted surface modification is expanding its applications to not only bone biosubstitutes but also cardiovascular devices, biosensors, neuron pseudosubstitutes, and sustainable drug delivery.
“the PDA-assisted surface modification is expanding its applications to not only bone biosubstitutes but also cardiovascular devices, biosensors, neuron pseudosubstitutes, and sustainable drug delivery [18, 99–101].”
From Polydopamine-Assisted Surface Modification for Bone Biosubstitutes (2016) · cites this paper as [100]
Cites
The effect of VEGF functionalization of titanium on endothelial cells in vitro
Poh, C. K., Shi, Z., Lim, T. Y., Neoh, K. G., & Wang, W. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2009.11.042 · Cited by 236 · see citing works
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Polydopamine-Assisted Surface Modification for Bone Biosubstitutes
Huang, S., Liang, N., Hu, Y., Zhou, X., & Abidi, N. (2016) · BioMed Research International · doi:10.1155/2016/2389895 · Cited by 97 · see citing works
“[99] W.”
Background
- Authors
- Shen, W., Cai, K., Yang, Z., Yan, Y., Yang, W., & Liu, P.
- Affiliations
- Chongqing University (CN)
- Corresponding author
- Liu, Peng
- Venue
- Colloids and Surfaces B: Biointerfaces
- Publisher
- Elsevier BV
- Published
- 2012-06
- Volume
- 94
- Pages
- 347-353
- ISSN
- 0927-7765 (ISSN-L)
- OpenAlex
- W2078269640
- Cited by
- 47
- References
- 1
- Citations by year
- 2026: 3 · 2025: 2 · 2023: 1 · 2022: 1 · 2021: 4 · 2020: 5 · 2019: 1 · 2018: 2 · 2017: 4 · 2016: 7 · 2015: 5 · 2014: 7 · 2013: 5
- FWCI
- 2.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Colloids and Surfaces B Biointerfaces (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Physical Sciences › Engineering › Mechanical Engineering › Surface Treatment and Coatings
- Physical Sciences › Materials Science › Materials Chemistry › Titanium Alloys Microstructure and Properties
- Keywords
- NiTi, endothelialization, vascular endothelial growth factor, polydopamine, nanostructured coatings, surface modification, nickel release, endothelial cell proliferation, nitric oxide, prostacyclin, vascular implants
- MeSH terms
- Alloys, Body Fluids, Cell Adhesion, Humans, Indoles, Microscopy, Electron, Scanning, Nickel, Nitric Oxide, Polymers, Epoprostenol, Surface Properties, Titanium, X-Ray Diffraction, Microscopy, Atomic Force, Coated Materials, Biocompatible, Tissue Engineering, Biomimetic Materials, Vascular Endothelial Growth Factor A, Cell Proliferation, Photoelectron Spectroscopy, Human Umbilical Vein Endothelial Cells
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