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The potential use of novel chitosan-coated deformable liposomes in an ocular drug delivery system
Abstract
In this study, novel chitosan-coated deformable liposomes (DL-CS) were proposed as an ocular drug delivery system to prolong pre-corneal retention, and improve transcorneal penetration and absorption. Flurbiprofen-loaded deformable liposomes (FP-DL) were prepared by a modified ethanol injection method and then coated with chitosan. Both DL and DL-CS exhibited a homogeneous particle size distribution, high encapsulation efficiency and good stability. After coating with 0.1% CS, the zeta potential was shifted from negative to positive. The apparent permeability coefficient of FP-DL-0.1% CS evaluated using isolated rabbit corneas was 1.29-, 1.95- and 4.59- fold greater than that of uncoated FP-DL, conventional liposomes and FP solution (P<0.01), respectively. The in vivo pre-corneal retention time and elimination dynamics were assessed using gamma scintigraphy technology. The area under the remaining activity-time of FP-DL-0.1% CS was prolonged 2.84- and 1.53-fold compared with that of the FP solution and FP-DL groups, respectively. Moreover, the ocular irritation test in vivo revealed that DL-0.1% CS produced no ocular damage or abnormal clinical signs. These results indicate that DL-CS appears to be a novel ophthalmic drug delivery strategy with the potential to overcome the limitations of conventional eye drops.
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“suggesting that the presence of CS on the outer surface of liposomes could improve the physical stability of liposomes (Chen et al., 2016, Zhou et al., 2018).”
From The use of chitosan-coated flexible liposomes as a remarkable carrier to enhance the antitumor efficacy of 5-fluorouracil against colorectal cancer (2019) · cites this paper as Chen et al., 2016
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“CS-coated liposomes have therefore gained mucoadhesive characteristics, which facilitate drug absorption with prolonged residence time (Chen et al., 2016, Zhou et al., 2018).”
From The use of chitosan-coated flexible liposomes as a remarkable carrier to enhance the antitumor efficacy of 5-fluorouracil against colorectal cancer (2019) · cites this paper as Chen et al., 2016
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Research works printed but not linked: 26
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Metadata
- Authors
- Chen, H., Pan, H., Li, P., Wang, H., Wang, X., Pan, W., & Yuan, Y.
- Venue
- Colloids and Surfaces B: Biointerfaces
- Publisher
- Elsevier BV
- Published
- 2016-07
- Volume
- 143
- Pages
- 455-462
- ISSN
- 0927-7765
- Cited by
- 115
- References
- 0
- Language
- en
- Funders
- National Natural Science Foundation of China (81202481, 81273447)
- Education Department of Liaoning Province (L2015527)
- Shenyang Pharmaceutical University (GGJJ2014102)
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- Chen, H., Pan, H., Li, P., Wang, H., Wang, X., Pan, W., & Yuan, Y. (2016). The potential use of novel chitosan-coated deformable liposomes in an ocular drug delivery system. Colloids and Surfaces B: Biointerfaces. https://doi.org/10.1016/j.colsurfb.2016.03.061
