Recent developments in nanomaterial-based shear-sensitive drug delivery systems
Open accessAbstract
Nanomaterial‐based drug delivery systems (DDSs) increase the efficacy of various therapeutics, and shear stress has been shown to be a robust modulator of payload release. In the past few decades, a deeper understanding has been gained of the effects of flow in the body and its alteration in pathological microenvironments. More recently, shear‐responsive nanomaterial DDSs have been developed. Studies on this subject mainly from the last decade are reviewed here, focusing on innovations of the material design and mechanisms of the shear response. The two most popular shear‐controlled drug carriers distinguished by different release mechanisms, that is, shear‐deformable nanoparticles (NPs) and shear‐dissociated NP aggregates (NPAs), are surveyed. The influence of material structures on their properties such as drug loading, circulation time, and shear sensitivity are discussed. The drug development stages, therapeutic effects, limitations, and potential of these DDSs are further inspected. The reviewed research emphasizes the advantages and significance of nanomaterial‐based shear‐sensitive DDSs in the field of targeted drug delivery. It is also believed that efforts to rationally design nanomaterial DDSs responsive to shear may prompt a new class of diagnostics and therapeutics for signaling and rectifying pathological flows in the body.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Shear stress-sensitive liposomes and polymeric nanoparticles can release anti-inflammatory or antifibrotic agents specifically at sites with elevated hemodynamic shear stress, enabling localized drug release triggered by mechanical forces.
“For example, shear stresssensitive liposomes and polymeric nanoparticles can release antiinflammatory or antifibrotic agents specifically at sites with elevated hemodynamic shear stress, enabling localized drug release triggered by mechanical forces (153, 154).”
From The mechanotransduction-immune axis in organ fibrosis: dual regulatory mechanisms and translational therapeutic perspectives (2025) · cites this paper as [154]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Nano based drug delivery systems: recent developments and future prospects
Patra, J. K., Das, G., Fraceto, L. F., Campos, E. V. R., Rodríguez-Torres, M. D. P., Acosta‐Torres, L. S., Diaz-Torres, L. A., Grillo, R., Swamy, M. K., Sharma, S., et al. (2018) · Journal of Nanobiotechnology · doi:10.1186/s12951-018-0392-8 · Cited by 6,720 · see citing works
Analysis of nanoparticle delivery to tumours
Wilhelm, S., Tavares, A. J., Dai, Q., Ohta, S., Audet, J., Dvorak, H. F., & Chan, W. C. W. (2016) · Nature Reviews Materials · doi:10.1038/natrevmats.2016.14 · Cited by 5,218 · see citing works
Liposome: classification, preparation, and applications
Akbarzadeh, A., Rezaei-Sadabady, R., Davaran, S., Joo, S. W., Zarghami, N., Hanifehpour, Y., Samiei, M., Kouhi, M., & Nejati‐Koshki, K. (2013) · Nanoscale Research Letters · doi:10.1186/1556-276x-8-102 · Cited by 3,648 · see citing works
Jiang, J., Oberdörster, G., & Biswas, P. (2009) · Journal of Nanoparticle Research · doi:10.1007/s11051-008-9446-4 · Cited by 1,713 · see citing works
The development of microgels/nanogels for drug delivery applications
Oh, J. K., Drumright, R., Siegwart, D. J., & Matyjaszewski, K. A. (2008) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2008.01.002 · Cited by 1,601 · see citing works
Voinova, M. V., Rodahl, M., Jonson, M., & Kasemo, B. (1999) · Physica Scripta · doi:10.1238/physica.regular.059a00391 · Cited by 1,591 · see citing works
Nanoparticles as drug delivery systems
Wilczewska, A. Z., Niemirowicz, K., Markiewicz, K. H., & Car, H. (2012) · Pharmacological Reports · doi:10.1016/s1734-1140(12)70901-5 · Cited by 1,445 · see citing works
Nanogels as Pharmaceutical Carriers: Finite Networks of Infinite Capabilities
Kabanov, A. V., & Vinogradov, S. V. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200900441 · Cited by 1,320 · see citing works
Nanocomposite hydrogels for biomedical applications
Gaharwar, A. K., Peppas, N. A., & Khademhosseini, A. (2013) · Biotechnology and Bioengineering · doi:10.1002/bit.25160 · Cited by 1,222 · see citing works
Advanced materials and processing for drug delivery: The past and the future
Zhang, Y., Chan, H. F., & Leong, K. W. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.10.003 · Cited by 1,008 · see citing works
Duan, X., & Li, Y. (2013) · Small · doi:10.1002/smll.201201390 · Cited by 926 · see citing works
Kroll, M., Hellums, J. D., McIntire, L., Schafer, A., & Moake, J. L. (1996) · Blood · doi:10.1182/blood.v88.5.1525.1525 · Cited by 924 · see citing works
Single-Polymer Dynamics in Steady Shear Flow
Smith, D. E., Babcock, H. P., & Chu, S. (1999) · Science · doi:10.1126/science.283.5408.1724 · Cited by 776 · see citing works
Nanosized cationic hydrogels for drug delivery: preparation, properties and interactions with cells
Vinogradov, S. V., Bronich, T. K., & Kabanov, A. V. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00245-9 · Cited by 776 · see citing works
Mechanical properties of nanoparticles: basics and applications
Guo, D., Xie, G., & Luo, J. (2013) · Journal of Physics D Applied Physics · doi:10.1088/0022-3727/47/1/013001 · Cited by 725 · see citing works
Stimuli-responsive bio-based polymeric systems and their applications
Gao, S., Tang, G., Hua, D., Xiong, R., Han, J., Jiang, S., Zhang, Q., & Huang, C. (2019) · Journal of Materials Chemistry B · doi:10.1039/c8tb02491j · Cited by 614 · see citing works
Atrp in the design of functional materials for biomedical applications
Siegwart, D. J., Oh, J. K., & Matyjaszewski, K. (2012) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2011.08.001 · Cited by 613 · see citing works
Shear-Activated Nanotherapeutics for Drug Targeting to Obstructed Blood Vessels
Korin, N., Kanapathipillai, M., Matthews, B. D., Crescente, M., Brill, A. G., Mammoto, T., Ghosh, K., Jurek, S., Bencherif, S. A., Bhatta, D. B., et al. (2012) · Science · doi:10.1126/science.1217815 · Cited by 543 · see citing works
Mechanoenzymatic Cleavage of the Ultralarge Vascular Protein von Willebrand Factor
Zhang, X. H., Halvorsen, K., Zhang, C., Wong, W. P., & Springer, T. A. (2009) · Science · doi:10.1126/science.1170905 · Cited by 519 · see citing works
Self-citationShear stress and the endothelium
Ballermann, B. J., Dardik, A., Eng, E., & Liu, A. (1998) · Kidney International · doi:10.1046/j.1523-1755.1998.06720.x · Cited by 441 · see citing works
Nanoparticle elasticity directs tumor uptake
Guo, P., Liu, D., Subramanyam, K. S., Wang, B., Yang, J., Huang, J., Auguste, D. T., & Moses, M. A. (2018) · Nature Communications · doi:10.1038/s41467-017-02588-9 · Cited by 425 · see citing works
Activation-independent platelet adhesion and aggregation under elevated shear stress
Ruggeri, Z. M., Orje, J. N., Habermann, R., Federici, A. B., & Reininger, A. J. (2006) · Blood · doi:10.1182/blood-2006-04-011551 · Cited by 416 · see citing works
Role of hemodynamic shear stress in cardiovascular disease
Cecchi, E., Giglioli, C., Valente, S., et al. (2010) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2010.09.008 · Cited by 404 · see citing works
Recent advances in shear‐thinning and self‐healing hydrogels for biomedical applications
Uman, S., Dhand, A. P., & Burdick, J. A. (2019) · Journal of Applied Polymer Science · doi:10.1002/app.48668 · Cited by 373 · see citing works
Mechanical Force-Triggered Drug Delivery
Zhang, Y., Yu, J., Bomba, H. N., Zhu, Y., & Gu, Z. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00369 · Cited by 358 · see citing works
Self-assembly of regular hollow icosahedra in salt-free catanionic solutions
Dubois, M., Demé, B., Gulik‐Krzywicki, T., et al. (2001) · Nature · doi:10.1038/35079541 · Cited by 345 · see citing works
Arterial Wall Shear Stress: Observations from the Bench to the Bedside
Paszkowiak, J. J., & Dardik, A. (2003) · Vascular and Endovascular Surgery · doi:10.1177/153857440303700107 · Cited by 344 · see citing works
Doshi, N., Prabhakarpandian, B., Rea-Ramsey, A., Pant, K., Sundaram, S., & Mitragotri, S. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.04.007 · Cited by 302 · see citing works
Role of high shear rate in thrombosis
Casa, L. D. C., Deaton, D. H., & Ku, D. N. (2015) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2014.12.050 · Cited by 295 · see citing works
Mucus Penetrating Nanoparticles: Biophysical Tool and Method of Drug and Gene Delivery
Ensign, L. M., Schneider, C. S., Suk, J. S., Cone, R. A., & Hanes, J. S. (2012) · Advanced Materials · doi:10.1002/adma.201201800 · Cited by 293 · see citing works
Dual-drug delivery system based on hydrogel/micelle composites
Lan, W., Cai, C., Lin, J., & Chen, T. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.01.006 · Cited by 292 · see citing works
Shear-stress sensitive lenticular vesicles for targeted drug delivery
Holme, M. N., Fedotenko, I., Abegg, D., Althaus, J., Babel, L., Favarger, F., Reiter, R., Tanasescu, R., Zaffalon, P.-L., Ziegler, A., et al. (2012) · Nature Nanotechnology · doi:10.1038/nnano.2012.84 · Cited by 290 · see citing works
Application of the Nano-Drug Delivery System in Treatment of Cardiovascular Diseases
Deng, Y., Zhang, X., Shen, H., He, Q., Wu, Z., Liao, W., & Yuan, M. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2019.00489 · Cited by 263 · see citing works
Self-citationKoutsiaris, A. G., Tachmitzi, S. V., Batis, N., Kotoula, M. G., Karabatsas, C. H., Tsironi, E., & Chatzoulis, D. (2007) · Biorheology · doi:10.1177/0006355x2007044005006008 · Cited by 246 · see citing works
Liposome-like nanostructures for drug delivery
Gao, W., Hu, C. J., Fang, R. H., & Zhang, L. (2013) · Journal of Materials Chemistry B · doi:10.1039/c3tb21238f · Cited by 246 · see citing works
Liu, M., Song, X., Wen, Y., et al. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b12849 · Cited by 245 · see citing works
Multiple‐Particle Tracking and Two‐Point Microrheology in Cells
Crocker, J. C., & Hoffman, B. D. (2007) · Methods in cell biology · doi:10.1016/s0091-679x(07)83007-x · Cited by 229 · see citing works
Transient pores in stretched vesicles: role of leak-out
Brochard‐Wyart, F., de Gennes, P. G., & Sandre, O. (2000) · Physica A Statistical Mechanics and its Applications · doi:10.1016/s0378-4371(99)00559-2 · Cited by 225 · see citing works
Colloidal stability of Pluronic F68-coated PLGA nanoparticles: A variety of stabilisation mechanisms
Santander-Ortega, M. J., Jódar‐Reyes, A. B., Csaba, N., Bastos‐González, D., & Ortega-Vinuesa, J. L. (2006) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2006.07.031 · Cited by 222 · see citing works
The influence of size, shape and vessel geometry on nanoparticle distribution
Tan, J., Shah, S., Thomas, A., Ou‐Yang, H. D., & Liu, Y. (2012) · Microfluidics and Nanofluidics · doi:10.1007/s10404-012-1024-5 · Cited by 201 · see citing works
Nanogel carrier design for targeted drug delivery
Eckmann, D. M., Composto, R. J., Tsourkas, A., & Muzykantov, V. R. (2014) · Journal of Materials Chemistry B · doi:10.1039/c4tb01141d · Cited by 199 · see citing works
Gabizon, A., Goren, D., Cohen, R., & Barenholz, Y. (1998) · Journal of Controlled Release · doi:10.1016/s0168-3659(97)00261-7 · Cited by 170 · see citing works
Shear Stress and Atherosclerosis
Heo, K., Fujiwara, K., & Abe, J. (2014) · Molecules and Cells · doi:10.14348/molcells.2014.0078 · Cited by 170 · see citing works
Zhang, C., Pan, D., Luo, K., She, W., Guo, C., Yang, Y., & Gu, Z. (2014) · Advanced Healthcare Materials · doi:10.1002/adhm.201300601 · Cited by 163 · see citing works
Environment sensitive hydrogels for drug delivery applications
Qureshi, D., Nayak, S. K., Maji, S., Anis, A., Kim, D., & Pal, K. (2019) · European Polymer Journal · doi:10.1016/j.eurpolymj.2019.109220 · Cited by 159 · see citing works
Folic Acid‐Modified Mesoporous Silica Nanoparticles for Cellular and Nuclear Targeted Drug Delivery
Porta, F., Lamers, G. E. M., Morrhayim, J., Chatzopoulou, A., Schaaf, M. J. M., den Dulk, H., Backendorf, C., Zink, J. I., & Kros, A. (2012) · Advanced Healthcare Materials · doi:10.1002/adhm.201200176 · Cited by 154 · see citing works
Zhao, Z., Ukidve, A., Gao, Y., Kim, J., & Mitragotri, S. (2019) · Science Advances · doi:10.1126/sciadv.aax9250 · Cited by 151 · see citing works
Cell Delivery of Therapeutic Nanoparticles
McMillan, J., Batrakova, E. V., & Gendelman, H. E. (2011) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-416020-0.00014-0 · Cited by 137 · see citing works
Shape control through molecular segregation in giant surfactant aggregates
Dubois, M., Lizunov, V. A., Meister, A., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400837101 · Cited by 131 · see citing works
Mechanoresponsive materials for drug delivery: Harnessing forces for controlled release
Wang, J., Kaplan, J. A., Colson, Y. L., & Grinstaff, M. W. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.11.001 · Cited by 126 · see citing works
Electroresponsive Polymer–Carbon Nanotube Hydrogel Hybrids for Pulsatile Drug Delivery In Vivo
Servant, A., Methven, L., Williams, R., & Kostarelos, K. (2012) · Advanced Healthcare Materials · doi:10.1002/adhm.201200193 · Cited by 122 · see citing works
The potential use of novel chitosan-coated deformable liposomes in an ocular drug delivery system
Chen, H., Pan, H., Li, P., et al. (2016) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2016.03.061 · Cited by 116 · see citing works
High shear stress relates to intraplaque haemorrhage in asymptomatic carotid plaques
Tuenter, A., Selwaness, M., Lorza, A. M. A., et al. (2016) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2016.05.018 · Cited by 107 · see citing works
Na, J. H., Lee, S. Y., Lee, S., Koo, H., Min, K. H., Jeong, S. Y., Yuk, S. H., Kim, K., & Kwon, I. C. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.07.028 · Cited by 102 · see citing works
Myerson, J. W., Braender, B., Mcpherson, O., et al. (2018) · Advanced Materials · doi:10.1002/adma.201802373 · Cited by 99 · see citing works
Ultrasound-mediated drug delivery for cardiovascular disease
Sutton, J. T., Haworth, K. J., Pyne-Geithman, G. J., & Holland, C. (2013) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2013.772578 · Cited by 91 · see citing works
Ultrasound-sensitive nanoparticle aggregates for targeted drug delivery
Papa, A., Korin, N., Kanapathipillai, M., Mammoto, A., Mammoto, T., Jiang, A. R., Mannix, R. J., Uzun, O., Johnson, C. P., Bhatta, D. B., et al. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.06.003 · Cited by 85 · see citing works
The use of shear stress for targeted drug delivery
Saxer, T., Zumbuehl, A., & Müller, B. (2013) · Cardiovascular Research · doi:10.1093/cvr/cvt102 · Cited by 83 · see citing works
Papademetriou, I., Vedula, E., Charest, J., & Porter, T. (2018) · PLoS ONE · doi:10.1371/journal.pone.0205158 · Cited by 77 · see citing works
Breakage Rate of Colloidal Aggregates in Shear Flow through Stokesian Dynamics
Harshe, Y. M., & Lattuada, M. (2011) · Langmuir · doi:10.1021/la2038476 · Cited by 76 · see citing works
Chen, C., Li, S., Liu, K., et al. (2016) · Small · doi:10.1002/smll.201600328 · Cited by 73 · see citing works
Gomez-Garcia, M. J., Doiron, A. L., Steele, R. R. M., Labouta, H. I., Vafadar, B., Shepherd, R. D., Gates, I. D., Cramb, D. T., Childs, S. J., & Rinker, K. D. (2018) · Nanoscale · doi:10.1039/c8nr03440k · Cited by 72 · see citing works
Ghoorchian, A., Simon, J. R., Bharti, B., et al. (2015) · Advanced Functional Materials · doi:10.1002/adfm.201500699 · Cited by 69 · see citing works
Shear-induced permeation and fusion of lipid vesicles
Bernard, A., Guedeau‐Boudeville, M., Marchi, V., et al. (2005) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2004.12.019 · Cited by 64 · see citing works
Shaping the platelet response to vascular injury
Stalker, T. J., Welsh, J. D., & Brass, L. F. (2014) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000070 · Cited by 64 · see citing works
Takeda, K. M., Yamasaki, Y., Dirisala, A., Ikeda, S., Tockary, T. A., Toh, K., Osada, K., & Kataoka, K. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.02.012 · Cited by 64 · see citing works
Molloy, C. P., Yu, Y., Kammoun, H. L., et al. (2017) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.13666 · Cited by 64 · see citing works
Injectable Hydrogel-Based Nanocomposites for Cardiovascular Diseases
Liao, X., Yang, X., Deng, H., et al. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00251 · Cited by 64 · see citing works
Korin, N., Gounis, M. J., Wakhloo, A. K., et al. (2014) · JAMA Neurology · doi:10.1001/jamaneurol.2014.2886 · Cited by 57 · see citing works
Exploring deformable particles in vascular-targeted drug delivery: Softer is only sometimes better
Fish, M. B., Fromen, C. A., Lopez‐Cazares, G., Golinski, A. W., Scott, T. F., Adili, R., Holinstat, M. A., & Eniola‐Adefeso, O. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.02.002 · Cited by 56 · see citing works
Rheological Analysis of the Gelation Kinetics of an Enzyme Cross-linked PEG Hydrogel
Chang, R. S. H., Lee, C.-W. J., Pedrón, S., Harley, B. A. C., & Rogers, S. A. (2019) · Biomacromolecules · doi:10.1021/acs.biomac.9b00116 · Cited by 54 · see citing works
Liu, Z., Xu, G., Wang, C., et al. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.07.063 · Cited by 53 · see citing works
Marosfoi, M. G., Korin, N., Gounis, M. J., et al. (2015) · Stroke · doi:10.1161/strokeaha.115.011063 · Cited by 51 · see citing works
Tosato, M. G., Girón, J. V. M., Martin, A. A., Tippavajhala, V. K., de Mele, M. F. L., & Dicelio, L. E. (2018) · Materials Science and Engineering C · doi:10.1016/j.msec.2018.04.073 · Cited by 49 · see citing works
Yao, S., Shen, M. L., Li, S. J., Wu, X. D., Zhang, M. M., Na, L., & Li, Y. (2019) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2019.110718 · Cited by 48 · see citing works
Carbamyl analogs of phosphatidylcholines
Gupta, C. M., & Bali, A. (1981) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(81)90178-8 · Cited by 45 · see citing works
Sunamoto, J., Goto, M., Iwamoto, K., et al. (1990) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(90)90346-p · Cited by 41 · see citing works
Shear targeted drug delivery to stenotic blood vessels
Epshtein, M., & Korin, N. (2016) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2016.11.015 · Cited by 39 · see citing works
Vesicle Origami: Cuboid Phospholipid Vesicles Formed by Template‐Free Self‐Assembly
Neuhaus, F., Mueller, D., Tanasescu, R., et al. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201701634 · Cited by 39 · see citing works
Bioinspired Mechano‐Sensitive Macroporous Ceramic Sponge for Logical Drug and Cell Delivery
Xu, C., Wei, Z., Gao, H., Bai, Y., Liu, H., Yang, H., Lai, Y., & Yang, L. (2017) · Advanced Science · doi:10.1002/advs.201600410 · Cited by 38 · see citing works
Conversion of an Injectable MMP-Degradable Hydrogel into Core-Cross-Linked Micelles
Najafi, M., Asadi, H., van den Dikkenberg, J. B., van Steenbergen, M. J., Fens, M. H. A. M., Hennink, W. E., & Vermonden, T. (2020) · Biomacromolecules · doi:10.1021/acs.biomac.9b01675 · Cited by 38 · see citing works
Bilayer Properties of 1,3-Diamidophospholipids
Weinberger, A., Tanasescu, R., Stefaniu, C., et al. (2015) · Langmuir · doi:10.1021/la5041745 · Cited by 29 · see citing works
The synthesis of 1,3-diamidophospholipids
Fedotenko, I., Zaffalon, P.-L., Favarger, F., et al. (2010) · Tetrahedron Letters · doi:10.1016/j.tetlet.2010.07.140 · Cited by 29 · see citing works
Shen, Z., Ye, H., Kröger, M., & Li, Y. (2017) · Physical Chemistry Chemical Physics · doi:10.1039/c7cp01530e · Cited by 28 · see citing works
Polyhedral vesicles: A Brownian dynamics simulation
Noguchi, H. (2003) · Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics · doi:10.1103/physreve.67.041901 · Cited by 27 · see citing works
Kang, T., Park, C., Choi, J.-S., Cui, J.-H., & Lee, B. (2015) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2015.12.001 · Cited by 26 · see citing works
Niu, Y., Yuan, X., Zhao, Y., Zhang, W., & Ren, L. (2017) · Macromolecular Chemistry and Physics · doi:10.1002/macp.201600540 · Cited by 25 · see citing works
Nurhidayah, D., Maruf, A., Zhang, X., et al. (2019) · Nanomedicine · doi:10.2217/nnm-2019-0172 · Cited by 21 · see citing works
Self-citationMonolayer Properties of 1,3-Diamidophospholipids
Fedotenko, I., Stefaniu, C., Brezesinski, G., et al. (2013) · Langmuir · doi:10.1021/la401692e · Cited by 21 · see citing works
Shear Reversible Cell/Microsphere Aggregate as an Injectable for Tissue Regeneration
Woo, E., Park, H., & Lee, K. Y. (2014) · Macromolecular Bioscience · doi:10.1002/mabi.201300365 · Cited by 20 · see citing works
Peng, B., Liu, Y., Zhou, Y., et al. (2015) · Nanoscale Research Letters · doi:10.1186/s11671-015-0942-z · Cited by 20 · see citing works
Immunological response to nitroglycerin-loaded shear-responsive liposomes in vitro and in vivo
Buscema, M., Matviykiv, S., Mészáros, T., et al. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.08.010 · Cited by 18 · see citing works
Buscema, M., Deyhle, H., Pfohl, T., et al. (2019) · Materials Today Bio · doi:10.1016/j.mtbio.2019.100003 · Cited by 18 · see citing works
Shear stress regulated uptake of liposome-decorated microgels coated with a poly(dopamine) shell
York-Durán, M. J., Ek, P. K., Godoy‐Gallardo, M., & Hosta‐Rigau, L. (2018) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2018.07.031 · Cited by 15 · see citing works
Kang, T., Cho, Y., Park, C., Kim, S.-D., Oh, E., Cui, J.-H., Cao, Q., & Lee, B. (2016) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2016.06.017 · Cited by 13 · see citing works
Shear Stress-sensitive Carriers for Localized Drug Delivery
Xia, Y., Shi, C.-Y., Xiong, W., et al. (2016) · Current Pharmaceutical Design · doi:10.2174/1381612822666160628081419 · Cited by 11 · see citing works
Synthesis and Biophysical Characterization of an Odd-Numbered 1,3-Diamidophospholipid
Neuhaus, F., Mueller, D., Tanasescu, R., et al. (2018) · Langmuir · doi:10.1021/acs.langmuir.7b04227 · Cited by 9 · see citing works
Arjmand, S., Pardakhty, A., Forootanfar, H., et al. (2018) · Medical Hypotheses · doi:10.1016/j.mehy.2018.09.022 · Cited by 9 · see citing works
Shear-, Sound-, and Light-Sensitive Nanoparticles for Thrombolytic Drug Delivery
Qu, S., & Ding, X. (2019) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0039-1688490 · Cited by 9 · see citing works
Wu, N., & Schultz, K. M. (2020) · Soft Matter · doi:10.1039/d0sm00630k · Cited by 8 · see citing works
Impact of Cross-Linker Valency on Gold Nanoparticle Aggregate Formation and Cellular Uptake
Liu, A. T., & Berlin, J. M. (2017) · Langmuir · doi:10.1021/acs.langmuir.7b03524 · Cited by 5 · see citing works
Matviykiv, S., Buscema, M., Gerganova, G., Mészáros, T., Kozma, G. T., Mettal, U., Neuhaus, F., Ishikawa, T., Szebeni, J., Zumbuehl, A., et al. (2018) · Precision Nanomedicine · doi:10.29016/180419.2 · Cited by 4 · see citing works
Flagged first, then by citations
Research works printed but not linked: 14
- [10]Streeter VL, Wylie EB, Fluid Mechanics. McGraw-Hill, New York, NY 1985
- [37]Brochard-Wyart F, de Gennes PG, Sandre O, Physica A 2000, 278, 32.
- [45]Fedotenko IA, Zaffalon PL, Favarger F, Zumbuehl A, Tetrahedron Letters 2010, 51, 5382.
- [52]Matviykiv S, Prec. Nanomed. 2018, 1, 43.
- [55]Oh JK, Drumright R, Siegwart DJ, Matyjaszewski K, Progress in Polymer Science 2008, 33, 448. PMC3604987 23525884
- [60]Uman S, Dhand A, Burdick JA, Journal of Applied Polymer Science 2020, 137, 48668.
- [62]Qureshi D, Nayak SK, Maji S, Anis A, Kim D, Pal K, European Polymer Journal 2019, 120, 109220.
- [63]Bhujbal SS, Darade SB, Dharmadhikari SS, International Journal of Pharmaceutical Sciences and Research 2020, 11, 1007.
- [68]Niu YL, Yuan XY, Zhao YH, Zhang WY, Ren LX, Macromolecular Chemistry and Physics 2017, 218, 1600540.
- [70]Ghoorchian A, Simon JR, Bharti B, Han W, Zhao XH, Chilkoti A, Lopez GP, Advanced Functional Materials 2015, 25, 3122.
- [74]Jiang JK, Oberdorster G, Biswas P, Journal of Nanoparticle Research 2009, 11, 77.
- [86]Guo D, Xie G, Luo J, J Phys D Appl Phys 2013, 47, 013001.
- [88]Voinova MV, Rodahl M, Jonson M, Kasemo B, Phys Scr 1999, 59, 391.
- [96]Kang T, Park C, Choi JS, Cui JH, Lee BJ, J Drug Deliv Sci Technol 2016, 31, 130.
Cited by
Sorted by citations
- Authors
- Wang, Y., Pisapati, A. V., Zhang, X. F., & Cheng, X.
- Affiliations
- Lehigh University (US)
- Department of Bioengineering Lehigh University Bethlehem PA 18015 USA
- Corresponding author
- Cheng, Xuanhong
- Venue
- Advanced Healthcare Materials
- Publisher
- Wiley
- Published
- 2021-06-02
- Volume
- 10
- Issue
- 13
- Pages
- e2002196-e2002196
- ISSN
- 2192-2640 (ISSN-L)
- 2192-2659
- PMC
- PMC8273148
- OpenAlex
- W3164892889
- Cited by
- 44
- References
- 102
- Citations by year
- 2026: 7 · 2025: 6 · 2024: 7 · 2023: 12 · 2022: 10 · 2021: 2
- FWCI
- 0.54
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Advanced Healthcare Materials (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (HL152348)
- National Science Foundation (2004475)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Keywords
- controlled drug release, targeted drug delivery, circulation time, drug loading
- MeSH terms
- Drug Development, Drug Carriers, Pharmaceutical Preparations, Drug Delivery Systems, Nanostructures, Nanoparticles
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review