Cited by 44Nanoparticle-Based Drug DeliveryAdvanced Drug Delivery SystemsHydrogels: synthesis, properties, applications

Recent developments in nanomaterial-based shear-sensitive drug delivery systems

Open access
Wang, Yi, Pisapati, Avani V., Zhang, X. Frank, Cheng, Xuanhong·2021·Advanced Healthcare Materials

Abstract

Nanomaterial‐based drug delivery systems (DDSs) increase the efficacy of various therapeutics, and shear stress has been shown to be a robust modulator of payload release. In the past few decades, a deeper understanding has been gained of the effects of flow in the body and its alteration in pathological microenvironments. More recently, shear‐responsive nanomaterial DDSs have been developed. Studies on this subject mainly from the last decade are reviewed here, focusing on innovations of the material design and mechanisms of the shear response. The two most popular shear‐controlled drug carriers distinguished by different release mechanisms, that is, shear‐deformable nanoparticles (NPs) and shear‐dissociated NP aggregates (NPAs), are surveyed. The influence of material structures on their properties such as drug loading, circulation time, and shear sensitivity are discussed. The drug development stages, therapeutic effects, limitations, and potential of these DDSs are further inspected. The reviewed research emphasizes the advantages and significance of nanomaterial‐based shear‐sensitive DDSs in the field of targeted drug delivery. It is also believed that efforts to rationally design nanomaterial DDSs responsive to shear may prompt a new class of diagnostics and therapeutics for signaling and rectifying pathological flows in the body.

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  • Shear stress-sensitive liposomes and polymeric nanoparticles can release anti-inflammatory or antifibrotic agents specifically at sites with elevated hemodynamic shear stress, enabling localized drug release triggered by mechanical forces.

    “For example, shear stresssensitive liposomes and polymeric nanoparticles can release antiinflammatory or antifibrotic agents specifically at sites with elevated hemodynamic shear stress, enabling localized drug release triggered by mechanical forces (153, 154).”

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Authors
Wang, Y., Pisapati, A. V., Zhang, X. F., & Cheng, X.
Affiliations
  • Lehigh University (US)
  • Department of Bioengineering Lehigh University Bethlehem PA 18015 USA
Corresponding author
Cheng, Xuanhong
Venue
Advanced Healthcare Materials
Publisher
Wiley
Published
2021-06-02
Volume
10
Issue
13
Pages
e2002196-e2002196
ISSN
  • 2192-2640 (ISSN-L)
  • 2192-2659
OpenAlex
W3164892889
Cited by
44
References
102
Citations by year
2026: 7 · 2025: 6 · 2024: 7 · 2023: 12 · 2022: 10 · 2021: 2
FWCI
0.54
Type
journal article
Language
en
Open access
Locations
  • Advanced Healthcare Materials (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (HL152348)
  • National Science Foundation (2004475)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
Keywords
controlled drug release, targeted drug delivery, circulation time, drug loading
MeSH terms
Drug Development, Drug Carriers, Pharmaceutical Preparations, Drug Delivery Systems, Nanostructures, Nanoparticles

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