CoChat
Sign Up
Cited by 110

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Dual drug loaded liposome bearing apigenin and 5-Fluorouracil for synergistic therapeutic efficacy in colorectal cancer

Sen, Kacoli, Banerjee, Shubhadeep, Mandal, Mahitosh·2019·Colloids and Surfaces B: Biointerfaces
DOI 10.1016/j.colsurfb.2019.04.035
Open this paper in CoChat — free account

Abstract

Multidrug-based combinatorial therapeutic regiments which target multiple pathways simultaneously are being utilized as a therapeutic strategy of choice due to reduction in toxicity profile and enhancement of therapeutic index of the individual drugs. 5-Fluorouracil is a clinically approved drug which has limited response rate in the realm of colorectal cancer amelioration, hence our study aims to improve its efficacy by aiming the simultaneous delivery of 5-Flurouracil and apigenin which is naturally occurring flavone abundantly present in fruit and vegetables through a single liposome to combat and control colorectal cancer effectively in-vitro and in-vivo. The liposomal nanocarrier bearing the anti-tumorigenic agent apigenin was designed in this study in order to improve the bioavailability of the flavone while at the same time achieve combinatorial drug regime with 5- Fluorouracil. This study reports the synthesis and production of a relatively robust dual drug-loaded liposomal formulation by modified thin film hydration method which substantially entraps both the drugs. Even though there have been reports of the combinatorial regimen involving apigenin and 5-Flurouracil our study reports the optimal molar ratio for effective synergistic therapeutic application of this drug combination to alleviate colorectal cancer. The cytotoxicity and cellular effects of individual, combinatorial free drugs and their liposomal counterparts tested against two human colon cancer cell lin…

Overview

Integrity signals

Registry

Crossref · 10.1016/j.colsurfb.2019.04.035

Cites

3 of 3 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 3 references

Research works printed but not linked: 36

  1. Sen, 2013, Second generation liposomal cancer therapeutics: transition from laboratory to clinic, Int. J. Pharm., 448, 28, 10.1016/j.ijpharm.2013.03.006 · DOI
  2. Hu, 2012, Nanoparticle-based combination therapy toward overcoming drug resistance in cancer, Biochem. Pharmacol., 83, 1104, 10.1016/j.bcp.2012.01.008 · DOI
  3. Gowda, 2013, Use of nanotechnology to develop multi-drug inhibitors for cancer therapy, J. Nanomed. Nanotechnol., 04, 10.4172/2157-7439.1000184 · DOI
  4. Sen, 2014, Abstract 4594: reversal of Warburg effect by Apigenin and 5-fluorouracil loaded dual drug liposomes result in enhanced colorectal chemotherapy, Cancer Res., 74, 10.1158/1538-7445.AM2014-4594 · DOI
  5. Labianca, 2010, Primary colon cancer: ESMO Clinical Practice Guidelines for diagnosis, adjuvant treatment and follow-up, Ann. Oncol., 21, v70, 10.1093/annonc/mdq168 · DOI
  6. Rajamanickam, 2008, Natural products and colon cancer: current status and future prospects, Drug Dev. Res., 69, 460, 10.1002/ddr.20276 · DOI
  7. Gaballah, 2017, Apigenin potentiates the antitumor activity of 5-FU on solid Ehrlich carcinoma: crosstalk between apoptotic and JNK-mediated autophagic cell death platforms, Toxicol. Appl. Pharmacol., 316, 27, 10.1016/j.taap.2016.12.012 · DOI
  8. Hu, 2015, 5-Fluorouracil combined with apigenin enhances anticancer activity through mitochondrial membrane potential (ΔΨm)-mediated apoptosis in hepatocellular carcinoma, Clin. Exp. Pharmacol. Physiol., 42, 146, 10.1111/1440-1681.12333 · DOI
  9. Banerjee, 2012, Poly(styrene-co-maleic acid)-based pH-sensitive liposomes mediate cytosolic delivery of drugs for enhanced cancer chemotherapy, Int. J. Pharm., 436, 786, 10.1016/j.ijpharm.2012.07.059 · DOI
  10. Banerjee, 2012, Probing molecular interactions of poly(styrene-co-maleic acid) with lipid matrix models to interpret the therapeutic potential of the co-polymer, Biochimica et Biophysica Acta (BBA) – Biomembranes, 1818, 537, 10.1016/j.bbamem.2011.12.010 · DOI
  11. Banerjee, 2017, Enhanced chemotherapeutic efficacy of apigenin liposomes in colorectal cancer based on flavone-membrane interactions, J. Colloid Interface Sci., 491, 98, 10.1016/j.jcis.2016.12.025 · DOI
  12. Ekambaram, 2011, Formulation and evaluation of solid lipid nanoparticles of ramipril, J. Young Pharm., 3, 216, 10.4103/0975-1483.83765 · DOI
  13. Bartlett, 1985, Citation classic - phosphorus assay in column chromatography, Cc/Life Sci
  14. Bijnsdorp, 2011, Analysis of drug interactions, Methods Mol Biol., 731, 421, 10.1007/978-1-61779-080-5_34 · DOI
  15. Franken, 2006, Clonogenic assay of cells in vitro, Nat. Protoc., 1, 2315, 10.1038/nprot.2006.339 · DOI
  16. Perumal, 2011, Effect of liposomal celecoxib on proliferation of colon cancer cell and inhibition of DMBA-induced tumor in rat model, Cancer Nanotechnol., 2, 67, 10.1007/s12645-011-0017-5 · DOI
  17. Eruslanov, 2010, Identification of ROS using oxidized DCFDA and flow-cytometry, Methods Mol Biol., 594, 57, 10.1007/978-1-60761-411-1_4 · DOI
  18. Wang, 2012, Ellagic acid, a phenolic compound, exerts anti-angiogenesis effects via VEGFR-2 signaling pathway in breast cancer, Breast Cancer Res. Treat., 134, 943, 10.1007/s10549-012-1977-9 · DOI
  19. Udofot, 2015, Cytotoxicity of 5-fluorouracil-loaded pH-sensitive liposomal nanoparticles in colorectal cancer cell lines, Integr. Cancer Sci. Ther., 2, 245
  20. Schwendener, 2010, Liposome formulations of hydrophobic drugs, Methods Mol Biol., 605, 129, 10.1007/978-1-60327-360-2_8 · DOI
  21. Chou, 2010, Drug combination studies and their synergy quantification using the chou-talalay method, Cancer Res., 70, 440, 10.1158/0008-5472.CAN-09-1947 · DOI · Paper page
  22. Ujiki, 2006, Mol. Cancer, 5, 76, 10.1186/1476-4598-5-76 · DOI
  23. Choi, 2009, Apigenin causes G2/M arrest associated with the modulation of p21Cip1 and Cdc2 and activates p53-dependent apoptosis pathway in human breast cancer SK-BR-3 cells, J. Nutr. Biochem., 20, 285, 10.1016/j.jnutbio.2008.03.005 · DOI
  24. Banerjee, 2015, Oxidative stress triggered by naturally occurring flavone apigenin results in senescence and chemotherapeutic effect in human colorectal cancer cells, Redox Biol., 5, 153, 10.1016/j.redox.2015.04.009 · DOI
  25. Choi, 2008, Size dependent and reactive oxygen species related nanosilver toxicity to nitrifying bacteria, Environ. Sci. Technol., 42, 4583, 10.1021/es703238h · DOI
  26. Kim, 2013, Targeting the AMP-activated protein kinase for cancer prevention and therapy, Front. Oncol., 3, 10.3389/fonc.2013.00175 · DOI
  27. Tong, 2012, Apigenin, a chemopreventive bioflavonoid, induces AMP-activated protein kinase activation in human keratinocytes, Mol. Carcinog., 51, 268, 10.1002/mc.20793 · DOI
  28. Hwang, 2005, Combination of 5-fluorouracil and genistein induces apoptosis synergistically in chemo-resistant cancer cells through the modulation of AMPK and COX-2 signaling pathways, Biochem. Biophys. Res. Commun., 332, 433, 10.1016/j.bbrc.2005.04.143 · DOI
  29. Ahmad, 2012, Acute exposure of apigenin induces hepatotoxicity in swiss mice, PLoS One, 7
  30. Saito, 1999, A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumor activity against human tumors, Proc. Natl. Acad. Sci., 96, 4592, 10.1073/pnas.96.8.4592 · DOI
  31. Chou, 2008, Preclinicalversusclinical drug combination studies, Leuk. Lymphoma, 49, 2059, 10.1080/10428190802353591 · DOI
  32. Banerjee, 2015, Probing the potential of apigenin liposomes in enhancing bacterial membrane perturbation and integrity loss, J. Colloid Interface Sci., 453, 48, 10.1016/j.jcis.2015.04.030 · DOI
  33. Nieman, 2011, Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth, Nat. Med., 17, 1498, 10.1038/nm.2492 · DOI · Paper page
  34. Kumar, 2014, Abstract 4116: grape seed extract impairs adipocyte-colorectal cancer cell interaction and decreases adipocyte-driven colon cancer stem colonosphere formation, Cancer Res., 74, 10.1158/1538-7445.AM2014-4116 · DOI
  35. Cort, 2015, Natural product modulators to overcome multidrug resistance in cancer, Nutr. Cancer, 67, 411, 10.1080/01635581.2015.1002624 · DOI
  36. Kuo, 1996, Antiproliferative potency of structurally distinct dietary flavonoids on human colon cancer cells, Cancer Lett., 110, 41, 10.1016/S0304-3835(96)04458-8 · DOI

Cited by

Sorted by citations

See all 110

Metadata

Authors
Sen, K., Banerjee, S., & Mandal, M.
Venue
Colloids and Surfaces B: Biointerfaces
Publisher
Elsevier BV
Published
2019-08
Volume
180
Pages
9-22
ISSN
0927-7765
DOI
10.1016/j.colsurfb.2019.04.035
Cited by
110
References
3
Language
en
Licence
Funders
  • Department of Science and Technology, Ministry of Science and Technology (SR/SO/BB-58/2008)
  • University Grants Commission (2-16/98)
  • Ministry of Science and Technology, Taiwan
  • Department of Biotechnology , Ministry of Science and Technology (BT/PR13996/Med/30/309/2010)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Dual drug loaded liposome bearing apigenin and 5-Fluorouracil for synergistic therapeutic efficacy in colorectal cancer. https://app.cochat.ai/papers/10.1016/j.colsurfb.2019.04.035
The paper
Sen, K., Banerjee, S., & Mandal, M. (2019). Dual drug loaded liposome bearing apigenin and 5-Fluorouracil for synergistic therapeutic efficacy in colorectal cancer. Colloids and Surfaces B: Biointerfaces. https://doi.org/10.1016/j.colsurfb.2019.04.035