Cited by 4,233Nanoparticle-Based Drug DeliveryNanoplatforms for cancer theranosticsRadiation Therapy and Dosimetry

Nanoparticle therapeutics: an emerging treatment modality for cancer

Davis, Mark E., Chen, Zhuo, Shin, Dong M.·2008·Nature Reviews Drug Discovery

Abstract

Nanoparticles--particles in the size range 1-100 nm--are emerging as a class of therapeutics for cancer. Early clinical results suggest that nanoparticle therapeutics can show enhanced efficacy, while simultaneously reducing side effects, owing to properties such as more targeted localization in tumours and active cellular uptake. Here, we highlight the features of nanoparticle therapeutics that distinguish them from previous anticancer therapies, and describe how these features provide the potential for therapeutic effects that are not achievable with other modalities. While large numbers of preclinical studies have been published, the emphasis here is placed on preclinical and clinical studies that are likely to affect clinical investigations and their implications for advancing the treatment of patients with cancer.

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Crossref · 10.1038/nrd2614

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Authors
Davis, M. E., Chen, Z., & Shin, D. M.
Affiliations
  • California Institute of Technology (US)
  • Emory University (US)
Corresponding author
Davis, Mark E.
Venue
Nature Reviews Drug Discovery
Published
2008-09
Volume
7
Issue
9
Pages
771-782
ISSN
  • 1474-1776 (ISSN-L)
  • 1474-1784
OpenAlex
W2082511916
Cited by
4,233
References
108
Citations by year
2026: 68 · 2025: 134 · 2024: 165 · 2023: 143 · 2022: 171 · 2021: 217 · 2020: 224 · 2019: 260 · 2018: 316 · 2017: 340 · 2016: 364 · 2015: 383 · 2014: 385 · 2013: 332 · 2012: 268
FWCI
7.10
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Reviews Drug Discovery (publishedVersion)
  • PubMed (publishedVersion)
  • CaltechAUTHORS (California Institute of Technology) (submittedVersion)
Funders
National Cancer Institute (U54CA119338)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Radiation Therapy and Dosimetry
Keywords
nanotherapeutics, cancer therapy, nanomedicine, targeted drug delivery, tumor localization, cellular uptake, clinical translation, clinical trials, anticancer agents, adverse drug reactions
MeSH terms
Animals, Antineoplastic Agents, Clinical Trials as Topic, Drug Evaluation, Preclinical, Humans, Neoplasms, Drug Delivery Systems, Nanoparticles

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