The interactome of CCT complex—a computational analysis
Abstract
The eukaryotic chaperonin, CCT (Chaperonin Containing TCP1 or TriC-TCP-1 Ring Complex) has been subjected to physical and genetic analyses in S. cerevisiae which can be extrapolated to human CCT (hCCT), owing to its structural and functional similarities with yeast CCT (yCCT). Studies on hCCT and its interactome acquire an additional dimension, as it has been implicated in several disease conditions like neurodegeneration and cancer. We attempt to study its stress response role in general, which will be reflected in the aspects of human diseases and yeast physiology, through computational analysis of the interactome. Towards consolidating and analysing the interactome data, we prepared and compared the unique CCT-interacting protein lists for S. cerevisiae and H. sapiens, performed GO term classification and enrichment studies which provide information on the diversity in CCT interactome, in terms of protein classes in the data set. Enrichment with disease-associated proteins and pathways highlight the medical importance of CCT. Different analyses converge, suggesting the significance of WD-repeat proteins, protein kinases and cytoskeletal proteins in the interactome. The prevalence of proteasomal subunits and ribosomal proteins suggest a possible cross-talk between protein-synthesis, folding and degradation machinery. A network of chaperones and chaperonins that function in combination can also be envisaged from the CCT interactome-Hsp70 interactome analysis.
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Computational analysis suggests substantial differences between the yeast and human CCT interactome.
“computational analysis suggests substantial differences between the yeast and human CCT interactome (Narayanan et al., 2016”
From Functional Genomic Screening Reveals Core Modulators of Echinocandin Stress Responses in Candida albicans (2018) · cites this paper as Narayanan et al., 2016
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- Authors
- Narayanan, A., Pullepu, D., & Kabir, M. A.
- Affiliations
- National Institute of Technology Calicut (IN)
- Corresponding author
- Kabir, M. Anaul
- Venue
- Computational Biology and Chemistry
- Publisher
- Elsevier BV
- Published
- 2016-10
- Volume
- 64
- Pages
- 396-402
- ISSN
- 1476-9271 (ISSN-L)
- OpenAlex
- W2511974557
- Cited by
- 29
- References
- 57
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 5 · 2021: 4 · 2020: 3 · 2019: 1 · 2018: 5 · 2017: 4 · 2016: 1
- FWCI
- 1.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Computational Biology and Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Council of Scientific and Industrial Research
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Keywords
- chaperonin, protein-protein interaction network, Saccharomyces cerevisiae, disease-associated proteins, stress response, WD-repeat proteins, protein kinases, cytoskeletal proteins, proteasome, ribosomal proteins, chaperone network, protein folding, protein degradation
- MeSH terms
- Computer Simulation, Humans, Saccharomyces cerevisiae, Stress, Physiological, HSP70 Heat-Shock Proteins, Genetic Diseases, Inborn, Chaperonin Containing TCP-1
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