Constrained global sensitivity analysis for bioprocess design space identification
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Each filter was tuned on a single batch and evaluated on the 3 held-out batches, whose feeding strategies span the galactose and uridine design space.
“Each filter was tuned on a single batch and evaluated on the 3 held-out batches, whose feeding strategies span the galactose and uridine design space [26].”
From Soft sensing of intracellular states for CHO cell bioprocessing with Ensemble Kalman Filters (2026) · cites this paper as [26]
Each validation experiment applied a distinct galactose and uridine supplementation profile, selected to span a design space constrained by requirements on product titre and galactosylation quality.
“Each experiment applied a distinct galactose and uridine supplementation profile, selected to span a design space constrained by requirements on product titre and galactosylation quality, as reported in [26].”
From Soft sensing of intracellular states for CHO cell bioprocessing with Ensemble Kalman Filters (2026) · cites this paper as [26]
The validation feeds expose the structural limitation because they span a wide galactose design space.
“the validation feeds expose it because they span a wide galactose design space [26]”
From Soft sensing of intracellular states for CHO cell bioprocessing with Ensemble Kalman Filters (2026) · cites this paper as [26]
Extrapolation of kinetic models has been shown to be poorly predictive of cellular regulation events owing to their reliance on fixed parameter values and predefined kinetic structures.
“While these kinetic models provide valuable mechanistic insight, extrapolation of these models has been shown to be poorly predictive of cellular regulation events [26], owing to their reliance on fixed parameter values and predefined kinetic structures.”
From Soft sensing of intracellular states for CHO cell bioprocessing with Ensemble Kalman Filters (2026) · cites this paper as [26]
Cites
Shinkawa, T., Nakamura, K., Yamane, N., Shoji-Hosaka, E., Kanda, Y., Sakurada, M., Uchida, K., Anazawa, H., Satoh, M., Yamasaki, M., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210665200 · Cited by 1,413 · see citing works
Yu, M., Brown, D., Reed, C., Chung, S., Lutman, J., Stefanich, E., Wong, A., Stephan, J.-P., & Bayer, R. (2012) · mAbs · doi:10.4161/mabs.20737 · Cited by 203 · see citing works
How does mild hypothermia affect monoclonal antibody glycosylation?
Sou, S. N., Sellick, C., Lee, K., Mason, A., Kyriakopoulos, S., Polizzi, K. M., & Kontoravdi, C. (2015) · Biotechnology and Bioengineering · doi:10.1002/bit.25524 · Cited by 107 · see citing works
Self-citationPlaninc, A., Dejaegher, B., Vander Heyden, Y., Viaene, J., Van Praet, S., Rappez, F., Van Antwerpen, P., & Delporte, C. (2017) · European Journal of Hospital Pharmacy · doi:10.1136/ejhpharm-2016-001022 · Cited by 41 · see citing works
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Bioprocess Control: Current Progress and Future Perspectives
Rathore, A. S., Mishra, S., Nikita, S., & Priyanka, P. (2021) · Life · doi:10.3390/life11060557 · Cited by 141 · see citing works
Soft sensing of intracellular states for CHO cell bioprocessing with Ensemble Kalman Filters
Yu, L., del Rio Chanona, A., & Kontoravdi, C. (2026) · Journal of Process Control · doi:10.1016/j.jprocont.2026.103875
Self-citation
- Authors
- Kotidis, P., Demis, P., Goey, C. H., Correa, E., McIntosh, C., Trepekli, S., Shah, N., Klymenko, O. V., & Kontoravdi, C.
- Affiliations
- Imperial College London (GB)
- University of Surrey (GB)
- Corresponding author
- Kontoravdi, Cleo
- Venue
- Computers & Chemical Engineering
- Publisher
- Elsevier BV
- Published
- 2019-06
- Volume
- 125
- Pages
- 558-568
- ISSN
- 0098-1354 (ISSN-L)
- OpenAlex
- W2921269266
- Cited by
- 40
- References
- 4
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 6 · 2023: 5 · 2022: 2 · 2021: 11 · 2020: 3 · 2019: 2
- FWCI
- 1.48
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- cc-by-nc-nd
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- Locations
- Computers & Chemical Engineering (publishedVersion)
- Surrey Research Insight Open Access (The University of Surrey) (submittedVersion)
- Spiral (Imperial College London) (submittedVersion, cc-by-nc-nd)
- Funders
- Biotechnology and Biological Sciences Research Council (EP/K038648/1)
- Engineering and Physical Sciences Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Viral Infectious Diseases and Gene Expression in Insects
- Social Sciences › Decision Sciences › Management Science and Operations Research › Optimal Experimental Design Methods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein purification and stability
- Keywords
- CHO cell culture, antibody production, feeding strategies, antibody titers, bioprocess development
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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