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Nanocomposite sponges of sodium alginate/graphene oxide/polyvinyl alcohol as potential wound dressing: In vitro and in vivo evaluation
Abstract
Abstract Wound dressings with high flexibility, mechanical strength, and porosity have received increasing attention. Herein, nanocomposite sponges of sodium alginate/graphene oxide (GO)/polyvinyl alcohol were prepared by a freeze-thawing cyclic process and freeze-dried molding. The properties of the sponges were investigated including morphology, mechanical properties, swelling, water vapor permeability, in vitro norfloxacin (NFX) release, antibacterial property, and biocompatibility as well as in vivo wound healing in a mouse model. A GO concentration of 1 wt% resulted in the sponges with a homogeneously porous and interconnected network structure, which exhibited suitable water absorption, breathability, and mechanical properties. Hemolysis tests indicated that the prepared sponges were non-hemolytic material. The CCK-8 assay demonstrated that the presence of an appropriate amount of GO could promote the cell proliferation. The sponges displayed excellent bioavailability of NFX, with a sustained release behavior and a strong inhibitory effect against both Escherichia coli and Staphylococcus aureus. The in vivo evaluations demonstrated that the sponges enhanced wound healing. Therefore, these novel nanocomposite sponges are promising candidates for wound healing applications.
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Citations
Cited by
Freeze/thawed polyvinyl alcohol hydrogels: Present, past and future
Adelnia, H., Ensandoost, R., Shebbrin Moonshi, S., Gavgani, J. N., Vasafi, E. I., & Ta, H. T. (2022) · European Polymer Journal · doi:10.1016/j.eurpolymj.2021.110974 · Cited by 566
Zhu, G., Cui, X., Zhang, Y., Chen, S., Dong, M., Liu, H., Shao, Q., Ding, T., Wu, S., & Guo, Z. (2019) · Polymer · doi:10.1016/j.polymer.2019.03.056 · Cited by 258
Self-citationShi, Z., Jia, C., Wang, D., Deng, J., Xu, G., Wu, C., Dong, M., & Guo, Z. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.04.128 · Cited by 96
Self-citationFang, W., Yang, L., Hong, L., & Hu, Q. (2021) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2021.118428 · Cited by 61
Alginate-based bio-nanohybrids with unique properties for biomedical applications
Qamar, S., Karim, S., Aslam, S., Jahangeer, M., Nelofer, R., Nadeem, A. A., Qamar, S. A., Jesionowski, T., & Bilal, M. (2024) · Starch - Stärke · doi:10.1002/star.202200100 · Cited by 46
Metadata
- Authors
- Ma, R., Wang, Y., Qi, H., Shi, C., Wei, G., Xiao, L., Huang, Z., Liu, S., Yu, H., Teng, C., Liu, H., Murugadoss, V., Zhang, J., Wang, Y., & Guo, Z.
- Venue
- Composites Part B: Engineering
- Publisher
- Elsevier BV
- Published
- 2019-06
- Volume
- 167
- Pages
- 396-405
- ISSN
- 1359-8368 (ISSN-L)
- OpenAlex
- W2922108286
- Cited by
- 327
- References
- 0
- FWCI
- 31.36
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ma, R., Wang, Y., Qi, H., Shi, C., Wei, G., Xiao, L., Huang, Z., Liu, S., Yu, H., Teng, C., Liu, H., Murugadoss, V., Zhang, J., Wang, Y., & Guo, Z. (2019). Nanocomposite sponges of sodium alginate/graphene oxide/polyvinyl alcohol as potential wound dressing: In vitro and in vivo evaluation. Composites Part B: Engineering. https://doi.org/10.1016/j.compositesb.2019.03.006
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