Prenatal exposure to tobacco and risk for schizophrenia: a retrospective epidemiological study
Abstract
Introduction In animal studies, long-term prenatal nicotinic exposure alters the development of dopaminergic neurons. To determine whether prenatal smoking exposure was associated with schizophrenia, using a retrospective design study, we compared the prevalence of tobacco use during pregnancy in mothers of subjects with and without schizophrenia. Methods One hundred patients with schizophrenia, 100 nonschizophrenic-matched subjects, and their respective mothers were interviewed. The prevalence of smoking was measured in these individuals as well as in their respective mothers during the pregnancy. Results Patients with schizophrenia smoked more often compared with controls (73% vs 57%). In contrast, the prevalence of smoking during pregnancy did not differ between the groups of mothers. Indeed, the amount of tobacco used was significantly lower in mothers of patients with schizophrenia vs mothers of nonpsychotic subjects. Conclusion This study did not show any association between prenatal tobacco exposure and further development of schizophrenia.
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In another case-control study of 100 patients with schizophrenia and 100 nonschizophrenia-matched subjects, the amount of tobacco used during pregnancy did not differ between mothers of cases and controls.
“Another case-control study of one hundred patients with schizophrenia and 100 nonschizophrenia-matched subjects, contrarily, found that the amount of tobacco used during pregnancy did not differ between the mothers of cases and controls [95].”
From Prenatal nicotine exposure during pregnancy results in adverse neurodevelopmental alterations and neurobehavioral deficits (2023) · cites this paper as [95]
In that case-control study, the amount of tobacco used was significantly lower in mothers of patients with schizophrenia versus mothers of non-schizophrenic subjects.
“Indeed, they found that the amount of tobacco used was significantly lower in the mothers of patients with schizophrenia versus the mothers of non-schizophrenic subjects.”
From Prenatal nicotine exposure during pregnancy results in adverse neurodevelopmental alterations and neurobehavioral deficits (2023) · cites this paper as [95]
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Developmental regulation of nicotinic acetylcholine receptors within midbrain dopamine neurons
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Davies, C., Segre, G., Estradé, A., Radua, J., De Micheli, A., Provenzani, U., Oliver, D., Salazar de Pablo, G., Ramella-Cravaro, V., Besozzi, M., et al. (2020) · The Lancet Psychiatry · doi:10.1016/s2215-0366(20)30057-2 · Cited by 301 · see citing works
Hunter, A., Murray, R., Asher, L., & Leonardi-Bee, J. (2020) · Nicotine & Tobacco Research · doi:10.1093/ntr/nty160 · Cited by 95 · see citing works
Prenatal nicotine exposure and risk of schizophrenia among offspring in a national birth cohort
Niemelä, S., Sourander, A., Surcel, H.-M., Hinkka-Yli-Salomäki, S., McKeague, I. W., Cheslack-Postava, K., & Brown, A. S. (2016) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2016.15060800 · Cited by 68 · see citing works
Wells, A. C., & Lotfipour, S. (2023) · Advances in Drug and Alcohol Research · doi:10.3389/adar.2023.11628 · Cited by 50 · see citing works
“Another case-control study of one hundred patients with schizophrenia and 100 nonschizophrenia-matched subjects, contrarily, found that the amount of tobacco used during pregnancy did not differ between the mothers of cases and controls [95].”
ResultZugno, A. I., Fraga, D. B., De Luca, R. D., Ghedim, F. V., Deroza, P. F., Cipriano, A. L., Oliveira, M. B., Heylmann, A. S. A., Budni, J., Souza, R. P., et al. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.02.001 · Cited by 23 · see citing works
Zugno, A. I., Oliveira, M. B., Mastella, G. A., Heylmann, A. S. A., Canever, L., Pacheco, F. D., Damazio, L. S., Citadin, S. A., de Lucca, L. A., Simões, L. R., et al. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.02.010 · Cited by 6 · see citing works
- Authors
- Baguelin-Pinaud, A., Robert, S., Ménard, J.-F., & Thibaut, F.
- Affiliations
- Inserm (FR)
- Centre Hospitalier Universitaire de Rouen (FR)
- Corresponding author
- Thibaut, Florence
- ORCID
- Thibaut, Florence
- Venue
- Comprehensive Psychiatry
- Publisher
- Elsevier BV
- Published
- 2010-03
- Volume
- 51
- Issue
- 2
- Pages
- 106-109
- ISSN
- 0010-440X (ISSN-L)
- OpenAlex
- W2017090091
- Cited by
- 17
- References
- 2
- Citations by year
- 2026: 1 · 2023: 2 · 2021: 1 · 2020: 1 · 2018: 1 · 2017: 3 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 4
- FWCI
- 0.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Comprehensive Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Keywords
- prenatal tobacco exposure, smoking during pregnancy, schizophrenia, nicotine, dopaminergic neurons, maternal smoking, schizophrenia risk
- MeSH terms
- Adult, Female, Fetus, Humans, Pregnancy, Prenatal Exposure Delayed Effects, Retrospective Studies, Risk Factors, Schizophrenia, Smoking, Tobacco Products, Nicotiana, Prevalence
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