Increased risk of developing schizophrenia in animals exposed to cigarette smoke during the gestational period
Open accessAbstract
Cigarette smoking during the prenatal period has been investigated as a causative factor of obstetric abnormalities, which lead to cognitive and behavioural changes associated with schizophrenia. The aim of this study was to investigate behaviour and AChE activity in brain structures in adult rats exposed to cigarette smoke during the prenatal period. Pregnant rats were divided into non-PCSE (non-prenatal cigarette smoke exposure) and PCSE (prenatal cigarette smoke exposure) groups. On post-natal day 60, the rats received saline or ketamine for 7days and were subjected to behavioural tasks. In the locomotor activity task, the non-PCSE+ketamine and PCSE+ketamine groups exhibited increased locomotor activity compared with the saline group. In the social interaction task, the non-PCSE+ketamine and PCSE+ketamine groups exhibited an increased latency compared with the control groups. However, the PCSE+ketamine group exhibited a decreased latency compared with the non-PCSE+ketamine group, which indicates that the cigarette exposure appeared to decrease, the social deficits generated by ketamine. In the inhibitory avoidance task, the non-PCSE+ketamine, PCSE, and PCSE+ketamine groups exhibited impairments in working memory, short-term memory, and long-term memory. In the pre-pulse inhibition (PPI) test, cigarette smoke associated with ketamine resulted in impaired PPI in 3 pre-pulse (PP) intensity groups compared with the control groups. In the biochemical analysis, the AChE activity in brain structures increased in the ketamine groups; however, the PCSE+ketamine group exhibited an exacerbated effect in all brain structures. The present study indicates that exposure to cigarette smoke during the prenatal period may affect behaviour and cerebral cholinergic structures during adulthood.
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Non-PCSE+ketamine and PCSE+ketamine groups exhibited increased locomotor activity likely resulting from NMDA receptor blockade.
“The non-PCSE + ketamine and PCSE + ketamine groups also exhibited increased locomotor activity which is likely resultant from an NMDA receptor blockade.”
From Prenatal nicotine exposure during pregnancy results in adverse neurodevelopmental alterations and neurobehavioral deficits (2023) · cites this paper as [99]
In the PPI test, PCSE+ketamine resulted in impaired PPI in 3 pre-pulse intensity groups compared with control groups.
“In the pre-pulse inhibition (PPI) test, PCSE + ketamine resulted in impaired PPI in 3 pre-pulse (PP) intensity groups as compared with the control groups, which is believed to be linked to a dysfunction in the sensorimotor gating mechanism.”
From Prenatal nicotine exposure during pregnancy results in adverse neurodevelopmental alterations and neurobehavioral deficits (2023) · cites this paper as [99]
In a follow-up rat study, non-PCSE+ketamine, PCSE, and PCSE+ketamine groups all exhibited impairments in long-term, short-term, and working memory in the inhibitory avoidance task.
“In the inhibitory avoidance task, the non-PCSE + ketamine, PCSE, and PCSE + ketamine groups all exhibited impairments in their long-term, short-term, and working memory.”
From Prenatal nicotine exposure during pregnancy results in adverse neurodevelopmental alterations and neurobehavioral deficits (2023) · cites this paper as [99]
Biochemical analysis revealed increased AChE activity in brain structures that was exacerbated in the PCSE+ketamine group.
“Their biochemical analysis also revealed increased AChE activity in brain structures that was exacerbated in the PCSE + ketamine group [99].”
From Prenatal nicotine exposure during pregnancy results in adverse neurodevelopmental alterations and neurobehavioral deficits (2023) · cites this paper as [99]
The PCSE+ketamine group exhibited decreased latency in the social interaction test compared with the non-PCSE+ketamine group.
“Lastly, the PCSE + ketamine group exhibited a decreased latency in the social interaction test as compared with the non-PCSE + ketamine group, indicating that cigarette exposure may decrease the social deficits”
From Prenatal nicotine exposure during pregnancy results in adverse neurodevelopmental alterations and neurobehavioral deficits (2023) · cites this paper as [99]
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Zugno, A. I., Fraga, D. B., De Luca, R. D., Ghedim, F. V., Deroza, P. F., Cipriano, A. L., Oliveira, M. B., Heylmann, A. S. A., Budni, J., Souza, R. P., et al. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.02.001 · Cited by 23 · see citing works
Self-citationCognitive and Behavioral Abnormalities in Children Whose Mothers Smoked Cigarettes during Pregnancy
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Zugno, A. I., Matos, M. P. P., Canever, L., Fraga, D. B., Luca, R. D. D., Ghedim, F. V., Deroza, P. F., de Oliveira, M. B., Pacheco, F. D., Valvassori, S. S., et al. (2013) · Acta Neuropsychiatrica · doi:10.1017/neu.2013.31 · Cited by 21 · see citing works
Self-citationZugno, A. I., Julião, R. F., Budni, J., Volpato, A. M., Fraga, D. B., Pacheco, F. D., Deroza, P. F., Luca, R. D. D., de Oliveira, M. B., Heylmann, A. S., et al. (2013) · Metabolic Brain Disease · doi:10.1007/s11011-013-9417-z · Cited by 20 · see citing works
Self-citationPre‐conditioning to global cerebral ischemia changes hippocampal acetylcholinesterase in the rat
Schetinger, M. R. C., Bonan, C. D., Frassetto, S. S., Wyse, Â. T. D. S., Schierholt, R. C., Webber, A., Dias, R. D., Sarkis, J. J. F., & Netto, C. A. (1999) · IUBMB Life · doi:10.1080/15216549900201503 · Cited by 19 · see citing works
Prenatal exposure to tobacco and risk for schizophrenia: a retrospective epidemiological study
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Therapie kognitiver Defizite durch AChE-Hemmer bei Patienten mit Schizophrenie
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Self-citationEffect of cigarette smoke exposure in the behavioral changes induced by ketamine
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Hunter, A., Murray, R., Asher, L., & Leonardi-Bee, J. (2020) · Nicotine & Tobacco Research · doi:10.1093/ntr/nty160 · Cited by 95 · see citing works
Wells, A. C., & Lotfipour, S. (2023) · Advances in Drug and Alcohol Research · doi:10.3389/adar.2023.11628 · Cited by 50 · see citing works
Canever, L., Freire, T., Mastella, G. A., Damázio, L. S., Gomes, S. T., Fachim, I., Michels, C., Carvalho, G., Godói, A. K., Peterle, B. R., et al. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.05.014 · Cited by 21 · see citing works
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Self-citationGodói, A. K., Canever, L., Rico, E. P., Mastella, G. A., Tonello, M., Veadrigo, N., Tomé, B. D. B., Lemos, I. D. S., STRECK, E. L., & Zugno, A. I. (2024) · Brain Research · doi:10.1016/j.brainres.2024.149270 · Cited by 1 · see citing works
Self-citationNicotine Exposure During Gestation: From Placental Dysfunction to Long‐Term Neurobehavioral Outcomes
Dave, H., Maru, S., & Johar, K. (2026) · Birth Defects Research · doi:10.1002/bdr2.70115
- Authors
- Zugno, A. I., Oliveira, M. B., Mastella, G. A., Heylmann, A. S. A., Canever, L., Pacheco, F. D., Damazio, L. S., Citadin, S. A., de Lucca, L. A., Simões, L. R., Malgarin, F., Budni, J., Barichello, T., Schuck, P. F., & Quevedo, J.
- Affiliations
- Universidade do Extremo Sul Catarinense (BR)
- Corresponding author
- Zugno, Alexandra I.
- ORCID
- Venue
- Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2017-04
- Volume
- 75
- Pages
- 199-206
- ISSN
- 0278-5846 (ISSN-L)
- OpenAlex
- W2588461435
- Cited by
- 6
- References
- 108
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 1 · 2020: 1 · 2018: 2
- FWCI
- 0.90
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Keywords
- prenatal cigarette smoke exposure, schizophrenia risk, ketamine, locomotor activity, social interaction, memory impairment, prepulse inhibition, acetylcholinesterase activity, social dysfunction, rat model
- MeSH terms
- Acetylcholinesterase, Analysis of Variance, Animals, Animals, Newborn, Avoidance Learning, Choline O-Acetyltransferase, Disease Models, Animal, Exploratory Behavior, Female, Inhibition, Psychological, Interpersonal Relations, Ketamine, Male, Pregnancy, Prenatal Exposure Delayed Effects, Schizophrenia, Smoking, Rats, Wistar, Excitatory Amino Acid Antagonists, Prepulse Inhibition
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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