Persistent neural activity: prevalence and mechanisms
Abstract
Persistent neural activity refers to a sustained change in action potential discharge that long outlasts a stimulus. It is found in a diverse set of brain regions and organisms and several in vitro systems, suggesting that it can be considered a universal form of circuit dynamics that can be used as a mechanism for short-term storage and accumulation of sensory or motor information. Both single cell and network mechanisms are likely to co-operate in generating persistent activity in many brain areas.
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Our work informs line attractor network models, for which the VPNI has served as a model system.
“Our work similarly informs line attractor network models, for which the VPNI has served as a model system53,54.”
From Predicting modular functions and neural coding of behavior from a synaptic wiring diagram (2024) · cites this paper as [53]
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References 77 · Cited by 320
- Authors
- Major, G., & Tank, D.
- Affiliations
- Princeton University (US)
- Corresponding author
- Major, Guy
- Tank, David
- Venue
- Current Opinion in Neurobiology
- Publisher
- Elsevier BV
- Published
- 2004-12
- Volume
- 14
- Issue
- 6
- Pages
- 675-684
- ISSN
- 0959-4388 (ISSN-L)
- OpenAlex
- W2137700545
- Cited by
- 320
- References
- 77
- Citations by year
- 2026: 5 · 2025: 18 · 2024: 15 · 2023: 16 · 2022: 9 · 2021: 17 · 2020: 14 · 2019: 9 · 2018: 19 · 2017: 11 · 2016: 19 · 2015: 25 · 2014: 26 · 2013: 17 · 2012: 16
- FWCI
- 0.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- persistent activity, action potential discharge, short-term memory, neural circuit dynamics, network mechanisms
- MeSH terms
- Action Potentials, Animals, Central Nervous System, Feedback, Humans, Nerve Net, Neural Pathways, Synaptic Transmission, Neuronal Plasticity, Neurons, Models, Animal
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