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Cited by 132Neuroinflammation and Neurodegeneration MechanismsNeuroscience and Neuropharmacology ResearchNeurogenesis and neuroplasticity mechanisms

Microglia dynamics and function in the CNS

Open access
Parkhurst, Christopher N, Gan, Wen-Biao·2010·Current Opinion in Neurobiology
DOI 10.1016/j.conb.2010.07.002PMC PMC3708473
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Abstract

Microglial cells constitute the resident immune cell population of the mammalian central nervous system. One striking feature of these cells is their highly dynamic nature under both normal and pathological brain conditions. The highly branched processes of resting microglia display a constitutive mobility and undergo rapid directional movement towards sites of acute tissue disruption. Microglia can be converted by a large number of different stimuli to a chronically activated state by signaling through both purinergic and Toll-like receptor systems, among others. Recent work has uncovered some of the mechanisms underlying microglia dynamics and shed new light into the functional significance of this enigmatic member of the glial cell family.

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  • Microglial function is highly dependent on baseline motility, which consists of the extension, retraction, and movement of microglial processes, allowing membrane ruffling.

    “Microglial function is highly dependent on baseline motility, which consists of the extension, retraction, and movement of microglial processes [37, 70], allowing membrane ruffling.”

    From Enhanced microglial dynamics and a paucity of tau seeding in the amyloid plaque microenvironment contribute to cognitive resilience in Alzheimer’s disease (2024) · cites this paper as [70]

    The section 'Baseline microglial dynamics and rapid process extension' describes constant movement of microglial processes and reports process extension and retraction. But it says the functional significance of baseline motility remains unknown, so it does not establish that microglial function is highly dependent on it. The cited text also does not describe membrane ruffling. (LLM, conf=0.87)

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References 56 · Cited by 132

Research works printed but not linked: 47

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Authors
Parkhurst, C. N., & Gan, W.-B.
Affiliations
New York University (US)
Corresponding author
Gan, Wen-Biao
ORCID
Venue
Current Opinion in Neurobiology
Publisher
Elsevier BV
Published
2010-10
Volume
20
Issue
5
Pages
595-600
ISSN
0959-4388 (ISSN-L)
DOI
10.1016/j.conb.2010.07.002
PMC
PMC3708473
OpenAlex
W2040533389
Cited by
132
References
56
Citations by year
2026: 5 · 2025: 6 · 2024: 10 · 2023: 6 · 2022: 25 · 2021: 11 · 2020: 9 · 2019: 10 · 2018: 5 · 2017: 6 · 2016: 6 · 2015: 10 · 2014: 8 · 2013: 4 · 2012: 7
FWCI
0.40
Type
journal article
Language
en
Open access
Licence
Locations
  • Current Opinion in Neurobiology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute of Neurological Disorders and Stroke (P01 NS048477, R01NS047325, P01NS048447, R01NS087198)
Topics
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
microglia, microglial dynamics, microglial motility, microglial activation, purinergic signaling, Toll-like receptors, central nervous system, glial cells, neuroinflammation
MeSH terms
Animals, Central Nervous System, Humans, Microglia

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