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Cited by 107Neuropeptides and Animal PhysiologyNeurobiology and Insect Physiology ResearchNeuroscience and Neuropharmacology Research

Neuropeptide modulation of microcircuits

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Nusbaum, Michael P, Blitz, Dawn M·2012·Current Opinion in Neurobiology
DOI 10.1016/j.conb.2012.01.003PMC PMC3346881
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Abstract

Neuropeptides provide functional flexibility to microcircuits, their inputs and effectors by modulating presynaptic and postsynaptic properties and intrinsic currents. Recent studies have relied less on applied neuropeptide and more on their neural release. In rhythmically active microcircuits (central pattern generators, CPGs), recent studies show that neuropeptide modulation can enable particular activity patterns by organizing specific circuit motifs. Neuropeptides can also modify microcircuit output indirectly, by modulating circuit inputs. Recently elucidated consequences of neuropeptide modulation include changes in motor patterns and behavior, stabilization of rhythmic motor patterns and changes in CPG sensitivity to sensory input. One aspect of neuropeptide modulation that remains enigmatic is the presence of multiple peptide family members in the same nervous system and even the same neurons.

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  • Other laboratories working on the same preparation also routinely perform the same baseline measurements.

    “Other laboratories working on the same preparation also routinely perform the same baseline measurements [7][8][9][10][11][12].”

    From A feature and not a bug: Replication failures can lead to new biology (2026) · cites this paper as [8]

    The Neuropeptide families and Modulating microcircuit organization and dynamics sections discuss experiments on stomatogastric circuits, but do not say that other laboratories routinely perform the same baseline measurements. Searches for “baseline” and for routine measurements by other laboratories found no passage addressing that practice. Page numbers were not available in our copy. (LLM, conf=0.74)

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Cited by

Sorted by citations

Authors
Nusbaum, M. P., & Blitz, D. M.
Affiliations
  • University of Pennsylvania (US)
  • Miami University (US)
Corresponding author
Nusbaum, Michael P
ORCID
Venue
Current Opinion in Neurobiology
Publisher
Elsevier BV
Published
2012-08
Volume
22
Issue
4
Pages
592-601
ISSN
0959-4388 (ISSN-L)
DOI
10.1016/j.conb.2012.01.003
PMC
PMC3346881
OpenAlex
W2027906603
Cited by
107
References
2
Citations by year
2026: 7 · 2025: 13 · 2024: 6 · 2023: 4 · 2022: 7 · 2021: 8 · 2020: 7 · 2019: 6 · 2018: 13 · 2017: 7 · 2016: 4 · 2015: 8 · 2014: 8 · 2013: 4 · 2012: 5
FWCI
0.85
Type
journal article
Language
en
Open access
Licence
Locations
  • Current Opinion in Neurobiology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Neurological Disorders and Stroke (R37NS029436, NS 29436, R01NS029436)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
neuropeptides, microcircuits, central pattern generator, rhythmic motor patterns, presynaptic modulation, postsynaptic modulation, sensory input, motor behavior
MeSH terms
Animals, Aplysia, Models, Neurological, Nerve Net, Neurons, Neuropeptides, Central Pattern Generators

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