Multiple neuropeptides in the Drosophila antennal lobe suggest complex modulatory circuits

Carlsson, Mikael A.; Diesner, Max; Schachtner, Joachim; Nässel, Dick R.

doi:10.1002/cne.22405

Cited by 146Neurobiology and Insect Physiology ResearchNeuropeptides and Animal PhysiologyNeuroscience and Neuropharmacology Research

Multiple neuropeptides in the Drosophila antennal lobe suggest complex modulatory circuits

Carlsson, Mikael A., Diesner, Max, Schachtner, Joachim, Nässel, Dick R.·2010·Journal of Comparative Neurology

DOI 10.1002/cne.22405

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Abstract

The fruitfly, Drosophila, is dependent on its olfactory sense in food search and reproduction. Processing of odorant information takes place in the antennal lobes, the primary olfactory center in the insect brain. Besides classical neurotransmitters, earlier studies have indicated the presence of a few neuropeptides in the olfactory system. In the present study we made an extensive analysis of the expression of neuropeptides in the Drosophila antennal lobes by direct profiling using matrix‐assisted laser desorption/ionization‐time‐of‐flight (MALDI‐TOF) mass spectrometry and immunocytochemistry. Neuropeptides from seven different precursor genes were unambiguously identified and their localization in neurons was subsequently revealed by immunocytochemistry. These were short neuropeptide F, tachykinin related peptide, allatostatin A, myoinhibitory peptide, SIFamide, IPNamide, and myosuppressin. The neuropeptides were expressed in subsets of olfactory sensory cells and different populations of local interneurons and extrinsic (centrifugal) neurons. In some neuron types neuropeptides were colocalized with classical neurotransmitters. Our findings suggest a huge complexity in peptidergic signaling in different circuits of the antennal lobe. J. Comp. Neurol. 518:3359–3380, 2010. © 2010 Wiley‐Liss, Inc.

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The "ALl1 dorsal" and "ALv2" hemilineages that produce antennal lobe local neurons seem to break Dale's law and Lacin's law, with similar morphology types predicted to express different transmitters.
“They seem to break Dale’s law104,106 and Lacin’s law (Figure 7C), with similar morphology types predicted to express different transmitters (Figures S5F and S5G).”
From Neurotransmitter classification from electron microscopy images at synaptic sites in Drosophila melanogaster (2024) · cites this paper as [106]
The fan-shaped body is known to express leucokinin, allatostatin A, short neuropeptide F, Drosophila neuropeptide F, tachykinin, proctolin, dFMRFa, SIFamide and myoinhibitory peptide in a highly specific and layer-wise manner.
“The fan-shaped body is known to express leucokinin, allatostatin A, short neuropeptide F, Drosophila neuropeptide F, tachykinin, proctolin, dFMRFa, SIFamide and myoinhibitory peptide in a highly specific and layer-wise manner.106,175,177,184”
From Neurotransmitter classification from electron microscopy images at synaptic sites in Drosophila melanogaster (2024) · cites this paper as [106]
Transmitter usage in antennal lobe local neurons breaks Dale's law, Lacin's law, and the expectation of uniform transmitter expression within a type.
“transmitter usage in these local neurons seems to break Dale’s law,104,106 Lacin’s law (Figure 7C) and the expectation of uniform transmitter expression within a type (Figures S5F and S5G)”
From Neurotransmitter classification from electron microscopy images at synaptic sites in Drosophila melanogaster (2024) · cites this paper as [106]
Some cholinergic local neurons have been mispredicted dopaminergic because at least approximately 3 cholinergic neurons co-express allatostatin A and approximately 10-15 co-express myoinhibitory peptide.
“We suspect that some cholinergic local neurons have been mispredicted dopaminergic because at least ∼ 3 cholinergic neurons co-express allatostatin A and ∼ 10-15 co-express myoinhibitory peptide.106”
From Neurotransmitter classification from electron microscopy images at synaptic sites in Drosophila melanogaster (2024) · cites this paper as [106]
Tachykinin co-expresses in approximately 40 GABAergic 'ALl1 dorsal' neurons per hemisphere.
“Tachykinin is also known to co-express in ∼ 40 GABAergic ‘ALl1 dorsal’ neurons per hemisphere106”
From Neurotransmitter classification from electron microscopy images at synaptic sites in Drosophila melanogaster (2024) · cites this paper as [106]

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Neurotransmitters and neuropeptides in olfactory circuits of the Drosophila brain
Enell, L. E. (2008)

Authors: Carlsson, M. A., Diesner, M., Schachtner, J., & Nässel, D. R.
Affiliations: Stockholm University (SE)
Philipps University of Marburg (DE)
Corresponding author: Carlsson, Mikael A.
Nässel, Dick R.
ORCID: Carlsson, Mikael A.
Diesner, Max
Schachtner, Joachim
Nässel, Dick R.
Venue: Journal of Comparative Neurology
Publisher: Wiley
Published: 2010-06-23
Volume: 518
Issue: 16
Pages: 3359-3380
ISSN: 0021-9967 (ISSN-L)
1096-9861
DOI: 10.1002/cne.22405
OpenAlex: W1979540477
Cited by: 146
References: 92
Citations by year: 2026: 6 · 2025: 7 · 2024: 8 · 2023: 6 · 2022: 5 · 2021: 12 · 2020: 5 · 2019: 4 · 2018: 9 · 2017: 11 · 2016: 10 · 2015: 11 · 2014: 13 · 2013: 12 · 2012: 13
FWCI: 5.03
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: The Journal of Comparative Neurology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: neuropeptides, olfactory system, short neuropeptide F, tachykinin-related peptides, allatostatin A, myoinhibitory peptides, SIFamide, myosuppressin, olfactory sensory neurons, local interneurons, neurotransmitter co-localization, peptidergic signaling, olfactory processing
MeSH terms: Amino Acid Sequence, Animals, Brain, Drosophila melanogaster, Female, Hormone Antagonists, Interneurons, Male, Molecular Sequence Data, Neuropeptides, Olfactory Pathways, Smell, Signal Transduction, Olfactory Receptor Neurons, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Drosophila Proteins

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Multiple neuropeptides in the Drosophila antennal lobe suggest complex modulatory circuits

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