Beyond pathology: APP, brain development and Alzheimer's disease
Abstract
Alzheimer's disease (AD) is the most common form of dementia among the elderly. Research in the AD field has been mostly focused on the biology of the Aβ peptide but increasing evidence is shifting attention toward the physiological role of APP as key to understanding AD pathology. It is becoming apparent that APP plays a central role in the mechanisms that guarantee the accuracy and the robustness of brain wiring. In the present review we explore APP functions with focus on some of the underlying molecular mechanisms.
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During development, APP is enriched in axonal growth cones and acts as a co-receptor for guidance cues through its interaction with the extracellular matrix.
“During development, APP is enriched in axonal growth cones and acts as a co-receptor for guidance cues through its interaction with the extracellular matrix [122, 123].”
From The new genetic landscape of Alzheimer’s disease: from amyloid cascade to genetically driven synaptic failure hypothesis? (2019) · cites this paper as [122]
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“However, all of the molecules that reached clinical trials failed [8].”
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Dourlen, P., Kilinc, D., Malmanche, N., Chapuis, J., & Lambert, J.-C. (2019) · Acta Neuropathologica · doi:10.1007/s00401-019-02004-0 · Cited by 168 · see citing works
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- Authors
- Soldano, A., & Hassan, B. A.
- Affiliations
- KU Leuven (BE)
- Corresponding author
- Hassan, Bassem A
- Venue
- Current Opinion in Neurobiology
- Publisher
- Elsevier BV
- Published
- 2014-08
- Volume
- 27
- Pages
- 61-67
- ISSN
- 0959-4388 (ISSN-L)
- OpenAlex
- W1982942777
- Cited by
- 54
- References
- 3
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 7 · 2023: 8 · 2022: 3 · 2021: 4 · 2020: 4 · 2019: 8 · 2018: 3 · 2017: 3 · 2016: 1 · 2015: 4 · 2014: 3
- FWCI
- 0.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- SDL (submittedVersion)
- Iris (University of Trento) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, amyloid precursor protein, APP, brain development, amyloid-beta, synaptic plasticity, neuronal connectivity
- MeSH terms
- Alzheimer Disease, Animals, Brain, Humans, Amyloid beta-Peptides, Amyloid beta-Protein Precursor
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