Generation of a neuro-specific microarray reveals novel differentially expressed noncoding RNAs in mouse models for neurodegenerative diseases
Open accessAbstract
We have generated a novel, neuro-specific ncRNA microarray, covering 1472 ncRNA species, to investigate their expression in different mouse models for central nervous system diseases. Thereby, we analyzed ncRNA expression in two mouse models with impaired calcium channel activity, implicated in Epilepsy or Parkinson's disease, respectively, as well as in a mouse model mimicking pathophysiological aspects of Alzheimer's disease. We identified well over a hundred differentially expressed ncRNAs, either from known classes of ncRNAs, such as miRNAs or snoRNAs or which represented entirely novel ncRNA species. Several differentially expressed ncRNAs in the calcium channel mouse models were assigned as miRNAs and target genes involved in calcium signaling, thus suggesting feedback regulation of miRNAs by calcium signaling. In the Alzheimer mouse model, we identified two snoRNAs, whose expression was deregulated prior to amyloid plaque formation. Interestingly, the presence of snoRNAs could be detected in cerebral spine fluid samples in humans, thus potentially serving as early diagnostic markers for Alzheimer's disease. In addition to known ncRNAs species, we also identified 63 differentially expressed, entirely novel ncRNA candidates, located in intronic or intergenic regions of the mouse genome, genomic locations, which previously have been shown to harbor the majority of functional ncRNAs.
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Differential expression of snoRNAs has been observed in brain of AD model mice and was associated with initial progression of amyloid depositions.
“Differential expression of snoRNAs has been observed in brain of AD model mice and were associated with the initial progression of amyloid depositions (Gstir et al., 2014).”
From Small nucleolar RNAs in plasma extracellular vesicles and their discriminatory power as diagnostic biomarkers of Alzheimer's disease (2021) · cites this paper as Gstir et al., 2014
The Results and Discussion section on young 3xTG mice reports differential expression of snoRNAs e307 and e470 in cortical samples. It says these changes occurred before β-amyloid plaque formation and were no longer observed after plaques formed; it does not establish an association with the initial progression of amyloid deposition. No page number is available in our copy. (LLM, conf=0.87)
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- Authors
- Gstir, R., Schafferer, S., Scheideler, M., Misslinger, M., Griehl, M., Daschil, N., Humpel, C., Obermair, G. J., Schmuckermair, C., Striessnig, J., Flucher, B. E., & Hüttenhofer, A.
- Affiliations
- Innsbruck Medical University (AT)
- Graz University of Technology (AT)
- Universität Innsbruck (AT)
- Corresponding author
- Hüttenhofer, Alexander
- ORCID
- Venue
- RNA
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2014-10-24
- Volume
- 20
- Issue
- 12
- Pages
- 1929-1943
- ISSN
- 1355-8382 (ISSN-L)
- 1469-9001
- PMC
- PMC4238357
- OpenAlex
- W2134601791
- Cited by
- 36
- References
- 88
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 3 · 2018: 6 · 2017: 4 · 2016: 4 · 2015: 4
- FWCI
- 1.28
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- RNA (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- Austrian Science Fund (FWF SFB F4402, F4405, F4406, F4411, P25729-B19, FWF DK SPIN W1206-B05)
- European Commission (GA N 602133—ncRNAPain, DIABAT [HEALTH-F2–2011-278373])
- Medical University of Innsbruck
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Keywords
- non-coding RNA, neurodegenerative diseases, epilepsy, Parkinson's disease, Alzheimer's disease, microRNA, small nucleolar RNA, calcium signaling, amyloid plaques, cerebrospinal fluid biomarkers, mouse model
- MeSH terms
- Alzheimer Disease, Animals, Central Nervous System, Disease Models, Animal, Epilepsy, Gene Expression Regulation, Humans, Organ Specificity, Parkinson Disease, Calcium Channels, Genome, RNA, Untranslated, MicroRNAs, Tissue Array Analysis, Mice
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