Cytoskeleton dynamics in axon regeneration
Open accessAbstract
Recent years have seen cytoskeleton dynamics emerging as a key player in axon regeneration. The cytoskeleton, in particular microtubules and actin, ensures the growth of neuronal processes and maintains the singular, highly polarized shape of neurons. Following injury, adult central axons are tipped by a dystrophic structure, the retraction bulb, which prevents their regeneration. Abnormal cytoskeleton dynamics are responsible for the formation of this growth-incompetent structure but pharmacologically modulating cytoskeleton dynamics of injured axons can transform this structure into a growth-competent growth cone. The cytoskeleton also drives the migration of scar-forming cells after an injury. Targeting its dynamics modifies the composition of the inhibitory environment formed by scar tissue and renders it more permissive for regenerating axons. Hence, cytoskeleton dynamics represent an appealing target to promote axon regeneration. As some of cytoskeleton-targeting drugs are used in the clinics for other purposes, they hold the promise to be used as a basis for a regenerative therapy after a spinal cord injury.
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The observed changes in pathways related to cytoskeletal regulation and axon guidance in the trigeminal ganglion could potentially explain the observed changes in infraorbital nerve structure, as both are essential for structural plasticity.
“In this regard, the observed changes in pathways related to cytoskeletal regulation and axon guidance in the trigeminal ganglion could potentially explain the observed changes in infraorbital nerve structure, as both are essential for structural plasticity33,34.”
From A deep-learning framework reveals whole-body perturbations at cell level (2026) · cites this paper as [34]
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References 77 · Cited by 189
- Authors
- Blanquie, O., & Bradke, F.
- Affiliations
- German Center for Neurodegenerative Diseases (DE)
- Corresponding author
- Blanquie, Oriane
- Bradke, Frank
- Venue
- Current Opinion in Neurobiology
- Publisher
- Elsevier BV
- Published
- 2018-08
- Volume
- 51
- Pages
- 60-69
- ISSN
- 0959-4388 (ISSN-L)
- OpenAlex
- W2793015531
- Cited by
- 189
- References
- 77
- Citations by year
- 2026: 14 · 2025: 16 · 2024: 27 · 2023: 26 · 2022: 26 · 2021: 27 · 2020: 33 · 2019: 14 · 2018: 6
- FWCI
- 2.62
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Current Opinion in Neurobiology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DZNE Pub (submittedVersion, cc-by-nc-nd)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Keywords
- axon regeneration, cytoskeletal dynamics, microtubules, actin, growth cones, scar formation, spinal cord injury, regenerative therapy, neuronal polarity
- MeSH terms
- Animals, Axons, Cell Movement, Cicatrix, Cytoskeleton, Humans, Nerve Regeneration, Growth Cones
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