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The microbiota and the hypothalamus-pituitary-adrenocortical (HPA) axis, implications for anxiety and stress disorders
Abstract
There is growing evidence for the involvement of the gut-microbiota in the regulation of emotions, behavior, and higher cognitive functions through the 'microbiome-gut-brain axis'. This relationship between the gut microbiota and the brain is pivotal for the development of the newborn, which receives its commensal microbiota at birth; dysbiosis may result in altered neurodevelopment. The hypothalamus-pituitary-adrenocortical (HPA) axis is actively involved in the stress response but is undeveloped in the newborn. Here, we describe how changes in the commensal microbiota influence the normal development of the HPA axis and review recent findings describing the essential crosstalk between the gut microbiota and the HPA axis and suggesting a role for the maternal and commensal microbiota in the development of the HPA axis and of the stress response.
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“Chronic stress is associated with various cognitive deficits, systemic inflammation, premature aging, immune system dysfunction, and a higher likelihood of suffering from metabolic disorders such as diabetes, cardiovascular disease, and IBD (490–492).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [492]
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Metadata
- Authors
- Frankiensztajn, L. M., Elliott, E., & Koren, O.
- Affiliations
- Bar-Ilan University (IL)
- Corresponding author
- Koren, Omry
- Venue
- Current Opinion in Neurobiology
- Publisher
- Elsevier BV
- Published
- 2020-06
- Volume
- 62
- Pages
- 76-82
- ISSN
- 0959-4388 (ISSN-L)
- OpenAlex
- W3001554865
- Semantic Scholar
- 0e9123a1a9222171affe5d2de19471dc52c06747
- Cited by
- 248
- References
- 55
- Citations by year
- 2026: 28 · 2025: 54 · 2024: 47 · 2023: 50 · 2022: 38 · 2021: 21 · 2020: 9
- FWCI
- 2.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- gut microbiota, microbiome-gut-brain axis, anxiety disorders, stress response, neonatal neurodevelopment, maternal microbiota, commensal microbiota, dysbiosis, stress disorders
- MeSH terms
- Anxiety, Brain, Humans, Hypothalamo-Hypophyseal System, Pituitary-Adrenal System, Stress, Psychological, Microbiota
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