Cited by 249Gut microbiota and healthStress Responses and CortisolGastrointestinal motility and disorders

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The microbiota and the hypothalamus-pituitary-adrenocortical (HPA) axis, implications for anxiety and stress disorders

Frankiensztajn, Linoy Mia, Elliott, Evan, Koren, Omry·2020·Current Opinion in Neurobiology

DOI 10.1016/j.conb.2019.12.003

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Abstract

There is growing evidence for the involvement of the gut-microbiota in the regulation of emotions, behavior, and higher cognitive functions through the 'microbiome-gut-brain axis'. This relationship between the gut microbiota and the brain is pivotal for the development of the newborn, which receives its commensal microbiota at birth; dysbiosis may result in altered neurodevelopment. The hypothalamus-pituitary-adrenocortical (HPA) axis is actively involved in the stress response but is undeveloped in the newborn. Here, we describe how changes in the commensal microbiota influence the normal development of the HPA axis and review recent findings describing the essential crosstalk between the gut microbiota and the HPA axis and suggesting a role for the maternal and commensal microbiota in the development of the HPA axis and of the stress response.

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Authors: Frankiensztajn, L. M., Elliott, E., & Koren, O.
Affiliations: Bar-Ilan University (IL)
Corresponding author: Koren, Omry
ORCID: Elliott, Evan
Koren, Omry
Venue: Current Opinion in Neurobiology
Publisher: Elsevier BV
Published: 2020-06
Volume: 62
Pages: 76-82
ISSN: 0959-4388 (ISSN-L)
DOI: 10.1016/j.conb.2019.12.003
OpenAlex: W3001554865
Semantic Scholar: 0e9123a1a9222171affe5d2de19471dc52c06747
Cited by: 248
References: 55
Citations by year: 2026: 28 · 2025: 54 · 2024: 47 · 2023: 50 · 2022: 38 · 2021: 21 · 2020: 9
FWCI: 2.82
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Current Opinion in Neurobiology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords: gut microbiota, microbiome-gut-brain axis, anxiety disorders, stress response, neonatal neurodevelopment, maternal microbiota, commensal microbiota, dysbiosis, stress disorders
MeSH terms: Anxiety, Brain, Humans, Hypothalamo-Hypophyseal System, Pituitary-Adrenal System, Stress, Psychological, Microbiota

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The microbiota and the hypothalamus-pituitary-adrenocortical (HPA) axis, implications for anxiety and stress disorders

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