The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Reduction of the “burst release” of copper ions from copper-based intrauterine devices by organic inhibitors
Open accessAbstract
Background The copper intrauterine device is a contraceptive method that is based on the release of copper ions from a copper wire. Immediately after insertion, the dissolution of copper in the uterine fluid is markedly higher ("burst release") than that necessary for contraception action, leading to a variety of harmful effects.Study design Pretreatments with organic compounds [thiourea (TU) and purine (PU), 10(-4)-10(-2) M concentration range, 1- and 3-h immersion times] were tested. The dissolution of copper with and without pretreatments in TU and PU solutions was analyzed by conventional electrochemical techniques and surface analysis.Results Pretreatments in PU solutions reduced the initial corrosion rate of copper in simulated uterine solutions, with inhibitory efficiencies that depend on the PU concentration and on the immersion time assayed. Inhibitory efficiency values higher than 98% for pretreatments with ≥10(-3) M PU were found. Conversely, after TU pretreatments, a high copper release was measured.Conclusions It was concluded that 10(-3) M PU pretreatment is a promising strategy able to reduce the "burst release" of copper and to ensure contraceptive action.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Department of economic and social affairs
United Nations Department of Economic and Social Affairs (2025) · Energy Statistics Pocketbook · doi:10.18356/9789211069280c001 · Cited by 689
Intrauterine device insertion during the postpartum period: a systematic review
Kapp, N., & Curtis, K. M. (2009) · Contraception · doi:10.1016/j.contraception.2009.03.024 · Cited by 278
Ortiz, M. E., & Croxatto, H. B. (2007) · Contraception · doi:10.1016/j.contraception.2007.01.020 · Cited by 254
Attitudes and beliefs about the intrauterine device among teenagers and young women
Fleming, K. L., Sokoloff, A., & Raine, T. R. (2010) · Contraception · doi:10.1016/j.contraception.2010.02.020 · Cited by 150
de Chialvo, M. R. G., Salvarezza, R. C., MOLL, D. V. V., et al. (1985) · Electrochimica Acta · doi:10.1016/0013-4686(85)80012-8 · Cited by 139
Copper containing, framed intra-uterine devices for contraception
Kulier, R., O'Brien, P., Helmerhorst, F. M., et al. (2007) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005347.pub3 · Cited by 118
Intrauterine devices: mechanisms of action, safety, and efficacy
Mishell, D. R. (1998) · Contraception · doi:10.1016/s0010-7824(98)00082-1 · Cited by 100
Inhibition of copper corrosion in sodium nitrate solutions with nontoxic inhibitors
Scendo, M. (2008) · Corrosion Science · doi:10.1016/j.corsci.2008.02.015 · Cited by 94
O'Brien, P., Kulier, R., Helmerhorst, F. M., Usher-Patel, M., & d’Arcangues, C. (2008) · Contraception · doi:10.1016/j.contraception.2007.12.011 · Cited by 91
Influence of pH and oxygen on copper corrosion in simulated uterine fluid
Mora, N., Cano, E., Mora, E., et al. (2002) · Biomaterials · doi:10.1016/s0142-9612(01)00154-5 · Cited by 85
Cited by
Zinc as a non-hormonal contraceptive: a better alternative to the copper intrauterine device (IUD)
Shankie-Williams, K., Lindsay, L., Murphy, C., & Dowland, S. (2022) · doi:10.1101/2022.03.24.485705 · Cited by 3
Metadata
- Authors
- Alvarez, F., Schilardi, P. L., & de Mele, M. F. L.
- Affiliations
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Venue
- Contraception
- Publisher
- Elsevier BV
- Published
- 2012-01
- Volume
- 85
- Issue
- 1
- Pages
- 91-98
- ISSN
- 0010-7824 (ISSN-L)
- OpenAlex
- W2114346301
- Semantic Scholar
- 2d70fc0ffedfb9042fe31129a44936508ad4a1af
- Cited by
- 32
- References
- 49
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 5 · 2021: 2 · 2019: 4 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 5 · 2014: 1 · 2013: 2
- FWCI
- 0.94
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Contraception (publishedVersion)
- PubMed (publishedVersion)
- CONICET Digital (CONICET) (submittedVersion, cc-by-nc-nd)
- Funders
- Consejo Nacional de Investigaciones Científicas y Técnicas
- Universidad Nacional de La Plata (11/I129, 11/X532)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Health and Contraception
- Physical Sciences › Materials Science › Materials Chemistry › Corrosion Behavior and Inhibition
- Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antimicrobial agents and applications
- Keywords
- copper intrauterine device, burst release, copper ion release, corrosion inhibition, purines, thiourea, uterine fluid, corrosion rate, pretreatment, contraceptive devices
- MeSH terms
- Copper, Corrosion, Intrauterine Devices, Copper, Purines, Thiourea, Electrochemical Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
