The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Reduction of the “burst release” of copper ions from copper-based intrauterine devices by organic inhibitors
Open accessAbstract
Background The copper intrauterine device is a contraceptive method that is based on the release of copper ions from a copper wire. Immediately after insertion, the dissolution of copper in the uterine fluid is markedly higher ("burst release") than that necessary for contraception action, leading to a variety of harmful effects.Study design Pretreatments with organic compounds [thiourea (TU) and purine (PU), 10(-4)-10(-2) M concentration range, 1- and 3-h immersion times] were tested. The dissolution of copper with and without pretreatments in TU and PU solutions was analyzed by conventional electrochemical techniques and surface analysis.Results Pretreatments in PU solutions reduced the initial corrosion rate of copper in simulated uterine solutions, with inhibitory efficiencies that depend on the PU concentration and on the immersion time assayed. Inhibitory efficiency values higher than 98% for pretreatments with ≥10(-3) M PU were found. Conversely, after TU pretreatments, a high copper release was measured.Conclusions It was concluded that 10(-3) M PU pretreatment is a promising strategy able to reduce the "burst release" of copper and to ensure contraceptive action.
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Metadata
- Authors
- Alvarez, F., Schilardi, P. L., & de Mele, M. F. L.
- Affiliations
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Venue
- Contraception
- Publisher
- Elsevier BV
- Published
- 2012-01
- Volume
- 85
- Issue
- 1
- Pages
- 91-98
- ISSN
- 0010-7824 (ISSN-L)
- OpenAlex
- W2114346301
- Semantic Scholar
- 2d70fc0ffedfb9042fe31129a44936508ad4a1af
- Cited by
- 32
- References
- 49
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 5 · 2021: 2 · 2019: 4 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 5 · 2014: 1 · 2013: 2
- FWCI
- 0.94
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Contraception (publishedVersion)
- PubMed (publishedVersion)
- CONICET Digital (CONICET) (submittedVersion, cc-by-nc-nd)
- Funders
- Consejo Nacional de Investigaciones Científicas y Técnicas
- Universidad Nacional de La Plata (11/I129, 11/X532)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Health and Contraception
- Physical Sciences › Materials Science › Materials Chemistry › Corrosion Behavior and Inhibition
- Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antimicrobial agents and applications
- Keywords
- copper intrauterine device, burst release, copper ion release, corrosion inhibition, purines, thiourea, uterine fluid, corrosion rate, pretreatment, contraceptive devices
- MeSH terms
- Copper, Corrosion, Intrauterine Devices, Copper, Purines, Thiourea, Electrochemical Techniques
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