Bioreactor state estimation and control
Abstract
Advanced control methods have been effectively employed for industrial chemical processing for decades. Only recently, however, have model-based strategies been implemented for biological processes. Some notable advances include the enhancement of metabolic flux models to describe the dynamic behavior observed in biochemical reactors. The combination of more than one type of model in a hybrid form was shown to perform well for bioprocess control applications.
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Most applications of vibrational spectroscopy PAT require calibration and validation of chemometric models, with the exception of some analytes such as carotenoids measured through Raman.
“Most applications of vibrational spectroscopy PAT require calibration and validation of chemometric models [21, 48,102] with the exception of some analytes, for example carotenoids measured through Raman [94].”
From Microalgal process-monitoring based on high-selectivity spectroscopy tools: status and future perspectives (2018) · cites this paper as [102]
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References 46 · Cited by 74
- Authors
- Komives, C., & Parker, R. S.
- Affiliations
- San Jose State University (US)
- University of Pittsburgh (US)
- Corresponding author
- Komives, Claire
- Parker, Robert S
- ORCID
- Parker, Robert S
- Venue
- Current Opinion in Biotechnology
- Publisher
- Elsevier BV
- Published
- 2003-10
- Volume
- 14
- Issue
- 5
- Pages
- 468-474
- ISSN
- 0958-1669 (ISSN-L)
- OpenAlex
- W2080020056
- Cited by
- 74
- References
- 46
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 4 · 2019: 3 · 2018: 1 · 2017: 2 · 2016: 4 · 2015: 3 · 2014: 5 · 2013: 5 · 2012: 7
- FWCI
- 0.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Current Opinion in Biotechnology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Physical Sciences › Engineering › Control and Systems Engineering › Control Systems and Identification
- Physical Sciences › Engineering › Control and Systems Engineering › Advanced Control Systems Optimization
- Keywords
- bioprocess control, model-based control, hybrid model, biochemical reactors
- MeSH terms
- Algorithms, Computer Simulation, Hydrogen-Ion Concentration, Models, Theoretical, Temperature, Biomass, Bioreactors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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