The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
Lignin biosynthesis and its integration into metabolism
Open accessAbstract
Lignin is a principal structural component of cell walls in higher terrestrial plants. It reinforces the cell walls, facilitates water transport, and acts as a physical barrier to pathogens. Lignin is typically described as being composed of p-hydroxyphenyl (H), guaiacyl (G), and syringyl (S) units that derive from the polymerization of the hydroxycinnamyl alcohols, p-coumaryl, coniferyl, and sinapyl alcohol, respectively. However, lignin also derives from various other aromatic monomers. Here, we review the biosynthetic pathway to the lignin monomers, and how flux through the pathway is regulated. Upon perturbation of the phenylpropanoid pathway, pathway intermediates may successfully incorporate into the lignin polymer, thereby affecting its physicochemical properties, or may remain soluble as such or as derivatized molecules that might interfere with physiological processes.
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Cites
Lignin structure and its engineering
Ralph, J., Lapierre, C., & Boerjan, W. (2019) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2019.02.019 · Cited by 1,054
Self-citationLignin content in natural Populus variants affects sugar release
Studer, M. H., DeMartini, J. D., Davis, M. F., Sykes, R. W., Davison, B., Keller, M., Tuskan, G. A., & Wyman, C. E. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1009252108 · Cited by 587
Hydroxycinnamates in lignification
Ralph, J. (2010) · Phytochemistry Reviews · doi:10.1007/s11101-009-9141-9 · Cited by 584
Self-citationCaffeoyl Shikimate Esterase (CSE) Is an Enzyme in the Lignin Biosynthetic Pathway in Arabidopsis
Vanholme, R., Cesarino, I., Rataj, K., Xiao, Y., Sundin, L., Goeminne, G., Kim, H., Cross, J., Morreel, K., Araujo, P., et al. (2013) · Science · doi:10.1126/science.1241602 · Cited by 521
Self-citationThe Effects on Lignin Structure of Overexpression of Ferulate 5-Hydroxylase in Hybrid Poplar1
Stewart, J. J., Akiyama, T., Chapple, C., Ralph, J., & Mansfield, S. D. (2009) · Plant Physiology · doi:10.1104/pp.109.137059 · Cited by 425
Self-citationMetabolic engineering of novel lignin in biomass crops
Vanholme, R., Morreel, K., Darrah, C., Oyarce, P., Grabber, J. H., Ralph, J., & Boerjan, W. (2012) · New Phytologist · doi:10.1111/j.1469-8137.2012.04337.x · Cited by 424
Self-citationSibout, R., Eudes, A., Mouille, G., Pollet, B., Lapierre, C., Jouanin, L., & Séguin, A. (2005) · The Plant Cell · doi:10.1105/tpc.105.030767 · Cited by 391
Monolignol Ferulate Transferase Introduces Chemically Labile Linkages into the Lignin Backbone
Wilkerson, C. G., Mansfield, S. D., Lu, F., Withers, S., Park, J.-Y., Karlen, S. D., Gonzales-Vigil, E., Padmakshan, D., Unda, F., Rencoret, J., et al. (2014) · Science · doi:10.1126/science.1250161 · Cited by 386
Self-citationDisruption of Mediator rescues the stunted growth of a lignin-deficient Arabidopsis mutant
Bonawitz, N. D., Kim, J. I., Tobimatsu, Y., Ciesielski, P. N., Anderson, N. A., Ximenes, E., Maeda, J., Ralph, J., Donohoe, B. S., Ladisch, M., et al. (2014) · Nature · doi:10.1038/nature13084 · Cited by 366
Self-citationA Systems Biology View of Responses to Lignin Biosynthesis Perturbations in Arabidopsis
Vanholme, R., Storme, V., Vanholme, B., Sundin, L., Christensen, J. H., Goeminne, G., Halpin, C., Rohde, A., Morreel, K., & Boerjan, W. (2012) · The Plant Cell · doi:10.1105/tpc.112.102574 · Cited by 365
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Lignin structure and its engineering
Ralph, J., Lapierre, C., & Boerjan, W. (2019) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2019.02.019 · Cited by 1,054
Self-citationZhu, J., Yan, C., Zhang, X., Yang, C., Jiang, M., & Zhang, X. (2020) · Progress in Energy and Combustion Science · doi:10.1016/j.pecs.2019.100788 · Cited by 303
Kim, C. Y., Mitchell, A. J., Kastner, D. W., Albright, C. E., Gutierrez, M. A., Glinkerman, C. M., Kulik, H. J., & Weng, J.-K. (2023) · Nature Communications · doi:10.1038/s41467-023-36299-1 · Cited by 25
Metadata
- Authors
- Vanholme, R., De Meester, B., Ralph, J., & Boerjan, W.
- Venue
- Current Opinion in Biotechnology
- Publisher
- Elsevier BV
- Published
- 2019-04
- Volume
- 56
- Pages
- 230-239
- ISSN
- 0958-1669 (ISSN-L)
- OpenAlex
- W2936940452
- Cited by
- 837
- References
- 63
- FWCI
- 8.69
- Type
- journal article
- Language
- en
- Open access
- bronze
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