Drug exposure early in life: functional repercussions of changing neuropharmacology during sensitive periods of brain development
Abstract
Exposure to drugs early in life can have long-lasting implications for brain structure and function. Effects on the developing nervous system, before homeostatic regulatory mechanisms are properly calibrated, differ from those on mature systems. Recent studies show that permanent alterations in brain pharmacology and cell signaling are induced by early drug exposure, producing hypo- or hyperresponsiveness to environmental or pharmacological challenges later in life. As a result, children exposed to drugs pre- or postnatally might respond abnormally to therapeutics used to treat the very disorders that they later exhibit as a result of their previous drug exposure.
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Similar structural and behavioral defects of the PFC can be observed in kids with prenatal exposure to opioids, cocaine, amphetamines and other drugs-of-abuse.
“Similar structural and behavioral defects of the PFC can be observed in kids with prenatal exposure to opioids, cocaine, amphetamines and other drugs-of-abuse [322–330].”
From Development of prefrontal cortex (2022) · cites this paper as [325]
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References 67 · Cited by 105
- Authors
- Stanwood, G.
- Affiliations
- Vanderbilt University (US)
- Corresponding author
- Stanwood, G
- ORCID
- Stanwood, G
- Venue
- Current Opinion in Pharmacology
- Publisher
- Elsevier BV
- Published
- 2004-02
- Volume
- 4
- Issue
- 1
- Pages
- 65-71
- ISSN
- 1471-4892 (ISSN-L)
- OpenAlex
- W2021733070
- Cited by
- 105
- References
- 67
- Citations by year
- 2026: 3 · 2024: 1 · 2023: 1 · 2022: 4 · 2021: 2 · 2020: 3 · 2019: 2 · 2018: 3 · 2017: 1 · 2016: 1 · 2015: 6 · 2014: 6 · 2013: 6 · 2012: 2
- FWCI
- 6.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Drug Abuse (DA11165, R01DA011165)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P30HD015052, P30 HD-15052)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Life Sciences › Neuroscience › Developmental Neuroscience › Anesthesia and Neurotoxicity Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- prenatal drug exposure, early-life drug exposure, brain development, signal transduction, neuroplasticity, drug response, developmental programming
- MeSH terms
- Animals, Brain, Child, Developmental Disabilities, Female, Humans, Pregnancy, Prenatal Exposure Delayed Effects, Signal Transduction, Substance-Related Disorders
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