Cited by 667Treatment of Major DepressionNerve injury and regenerationNeurotransmitter Receptor Influence on Behavior

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Role of neurotrophic factors in depression

CASTREN, E, VOIKAR, V, RANTAMAKI, T·2007·Current Opinion in Pharmacology

DOI 10.1016/j.coph.2006.08.009

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Abstract

Major depression is associated with reduced volumes in the hippocampus and prefrontal cortex, whereas antidepressant treatments promote several forms of neuronal plasticity, including neurogenesis, synaptogenesis and neuronal maturation, in the hippocampus. Several neurotrophic factors are associated with depression or antidepressant action. Stress suppresses brain-derived neurotrophic factor (BDNF) synthesis in the hippocampus, at least partially through a sustained modification of chromatin structure. Essentially all antidepressant treatments increase BDNF synthesis and signaling in the hippocampus and prefrontal cortex. This signaling is required for the behavioral effects of antidepressant drugs in rodents, and increased BDNF levels in the hippocampus mimic the behavioral effects of antidepressants. However, injection of BDNF into the mesolimbic dopamine pathway produces an opposing depression-like response. One hypothesis emerging from these data proposes that mood disorders reflect failed function of critical neuronal networks, whereas a gradual network recovery through activity-dependent neuronal plasticity induces the antidepressant effect. Neurotrophic factors themselves do not control mood, but they act as necessary tools in the activity-dependent modulation of networks, the physiological function of which determines how a plastic change influences mood.

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Berton, O., McClung, C. A., DiLeone, R. J., Krishnan, V., Renthal, W., Russo, S. J., Graham, D., Tsankova, N. M., Bolanos, C. A., Rios, M., et al. (2006) · Science · doi:10.1126/science.1120972 · Cited by 2,129
The mesolimbic dopamine reward circuit in depression
Nestler, E. J., & Carlezon, W. A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.09.018 · Cited by 2,059
Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action
Tsankova, N. M., Berton, O., Renthal, W., Kumar, A., Neve, R. L., & Nestler, E. J. (2006) · Nature Neuroscience · doi:10.1038/nn1659 · Cited by 1,780
Increased hippocampal bdnf immunoreactivity in subjects treated with antidepressant medication
Chen, B., Dowlatshahi, D., MacQueen, G. M., Wang, J.-F., & Young, L. T. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01083-6 · Cited by 1,164
Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants
Shimizu, E., Hashimoto, K., Okamura, N., Koike, K., Komatsu, N., Kumakiri, C., Nakazato, M., Watanabe, H., Shinoda, N., Okada, S.-I., et al. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00181-1 · Cited by 1,151
Activation of the TrkB neurotrophin receptor is induced by antidepressant drugs and is required for antidepressant-induced behavioral effects
Saarelainen, T., Hendolin, P., Lucas, G., Koponen, E., Sairanen, M., MacDonald, E., Agerman, K., Haapasalo, A., Nawa, H., Aloyz, R., et al. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-01-00349.2003 · Cited by 800
Hippocampal neurogenesis: opposing effects of stress and antidepressant treatment
Warner‐Schmidt, J. L., & Duman, R. S. (2006) · Hippocampus · doi:10.1002/hipo.20156 · Cited by 787

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Chronic Stress and Depression
Fuchs, E., & Flügge, G. (2011) · Wiley eBooks · doi:10.1002/9781118083222.ch23 · Cited by 8
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Lee, C. Y. P. D., Park, K., Ahn, J., Jang, Y., Park, Y., Yu, H., Lee, D., Ihm, H. K., Lee, J., Kim, J., et al. (2025) · European Psychiatry · doi:10.1192/j.eurpsy.2024.1811 · Cited by 8
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Synthesis and biological evaluation of novel isobenzofuran-1(3H)-one derivatives as antidepressant agents
Tao, L., Yao, C., Wang, S., Ye, Y.-M., Tu, Z., Jiang, X., Xu, L., Shan, L., Liu, Z., & Yu, P. (2024) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2024.117941 · Cited by 7
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Hassanzadeh, P., Atyabi, F., & Dinarvand, R. (2015) · Biomedical Reviews · doi:10.14748/bmr.v26.1540 · Cited by 7
The Role of Vesicle Release and Synaptic Transmission in Depression
Zhang, C., Zhu, L., Shi, H., & Zhu, L. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2022.10.001 · Cited by 7
Role of Omega-3 Fatty Acids in Brain and Neurological Health with Special Reference to Clinical Depression
Chandola, H., & Tanna, I. R. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-410527-0.00014-4 · Cited by 7
Is Depression a Brain Disorder? Neuroscience in Mental Health Care
Helén, I. (2011) · Advances in medical sociology · doi:10.1108/s1057-6290(2011)0000013010 · Cited by 7
Highfield imaging of the subgenual anterior cingulate cortex in uni- and bipolar depression
Buchholz, F., Meffert, M., Bazin, P., Trampel, R., Turner, R., & Schönknecht, P. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1462919 · Cited by 7
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Common aspects of neuroplasticity, stress, mood disorders and mitochondrial functions
Hroudová, J., & Karlovu, K. (2010) · Cited by 6
Neurochemical Aspects of Neurological Disorders
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Memory impairments in rodent depression models: A link with depression theories
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Moghadas, M., & Edalatmanesh, M. A. (2014) · Comparative Clinical Pathology · doi:10.1007/s00580-014-2055-y · Cited by 6
The interactive effects of ketamine and magnesium upon depressive-like pathology
Hayley, S. P., Razmjou, S., Litteljohn, D., Rudyk, C., Syed, S., Clarke, M., Pentz, R., & Dwyer, Z. (2016) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s111131 · Cited by 6
Anti-depressant-like effects of Jieyu chufan capsules in a mouse model of unpredictable chronic mild stress
Zhao, H., Liang, B., Yu, L., & Xu, Y. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.4601 · Cited by 6
Effect of social interactions on hippocampal protein expression in animal dominant and submissive model of behavioral disorders
Borovok, N., Nesher, E., Reichenstein, M., Tikhonova, T. B., Levin, Y., Pinhasov, A., & Michaelevski, I. (2017) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201700089 · Cited by 6
Measuring nerve growth factor in saliva by immunoassay: A cautionary note
Matin, M. J., Li, D., Peterson, J., Taylor, M. K., Laurent, H. K., Lucas, T., Granger, S. J., Granger, D. A., & Granger, S. W. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.09.030 · Cited by 6
Collaborative depression care, screening, diagnosis and specificity of depression treatments in the primary care setting
Alexander, J. L., Richardson, G., Grypma, L., & Hunkeler, E. M. (2007) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.7.11s.s59 · Cited by 6
Antidepressant-like effects of erythropoietin : a focus on behavioural and hippocampal processes
Osborn, M. (2012) · Carleton University's Institutional Repository (MacOdrum Library, Carleton University) · doi:10.22215/etd/2012-07424 · Cited by 6
Neuroprotective Effects of High-Intensity Interval Training through Neuroplastic Changes in a Restraint Stress-Induced Depression Model
Hwang, D.-J., Um, H.-S., Choi, D.-H., & Cho, J. (2023) · Applied Sciences · doi:10.3390/app13137680 · Cited by 5
Neuroimaging Approaches to the Understanding of Depression and the Identification of Novel Antidepressants
Kumar, P., Harmer, C. J., & Dourish, C. T. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-386945-6.00012-3 · Cited by 6
Ketamine Induces Rapid Onset of Antidepressant Action: Neurophysiological Biomarkers as Predictors of Effect
Quevedo, J., Comim, C. M., & Gavioli, E. C. (2009) · Biomarkers in Medicine · doi:10.2217/17520363.3.1.5 · Cited by 5
Genetic Polymorphisms of Nervous System Development and the Risk of Posttraumatic Stress Disorder
Avetyan, D., Arakelyan, A., & Mkrtchyan, G. (2018) · American Journal of Molecular Biology · doi:10.4236/ajmb.2018.81005 · Cited by 5
Effects of Alcohol and Cocaine in a Mutant Mouse Model of Predisposition to Post-Traumatic Stress Disorder
Païzanis, E., Crotti, M., Petit, A., Règue, M., Beray‐Berthat, V., Noble, F., Lanfumey, L., & Mongeau, R. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00623 · Cited by 5
Neurotrophic factors in the porcine ovary: Their effects on follicular growth, oocyte maturation, and developmental competence
Kim, M., & Hyun, S. (2022) · Frontiers in Veterinary Science · doi:10.3389/fvets.2022.931402 · Cited by 5
Enterogenic metabolomics signatures of depression: what are the possibilities for the future
Zhang, Y., Chen, X., Mo, X., Xiao, R., Cheng, Q., Wang, H., Liu, L., & Xie, P. (2023) · Expert Review of Proteomics · doi:10.1080/14789450.2023.2279984 · Cited by 5
Neurotrophic Factors and Major Depressive Disorder
Zhang, X., Jin, L., Sha, W., & Bu, R. (2015) · InTech eBooks · doi:10.5772/59373 · Cited by 6
Histological and molecular techniques utilized to investigate animal models of depression. An updated review
Ayuob, N. N., & Balgoon, M. J. (2018) · Microscopy Research and Technique · doi:10.1002/jemt.23105 · Cited by 6
Investigating acupuncture therapy in depression: mechanisms of synaptic plasticity regulation
Si, Y., Ma, W., Zhang, Q., Zhang, Y., An, J., Zhang, M., Fu, Y., Yu, Y., Zhang, H., Fang, Y., et al. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.06.005 · Cited by 4
Astrocyte Intracellular Ca2+and TrkB Signaling in the Hippocampus Could Be Involved in the Beneficial Behavioral Effects of Antidepressant Treatment
Ferreira, F. R., Cupido, A., Cătălin, B., Silva, W. A., Kirchhoff, F., Bel, E. A. D., & Guimarães, F. S. (2021) · Neurotoxicity Research · doi:10.1007/s12640-021-00334-0 · Cited by 4
Neurotransmission in Mood Disorders
Fiar, Z., Hroudov, J., & Raboch, J. (2012) · InTech eBooks · doi:10.5772/31831 · Cited by 4
Early Developmental Trajectories of Brain Development: New Directions in the Search for Early Determinants of Health and Longevity
Cirulli, F., & Berry, A. (2012) · Springer eBooks · doi:10.1007/978-1-4614-5605-6_10 · Cited by 5
Trophic Factors: Neurotrophic Factors
Ċastrén, E. (2012) · Springer eBooks · doi:10.1007/978-1-4614-1997-6_55 · Cited by 4
Identification and characterization of neurotrophic factors in porcine small intestinal submucosa
Yang, K., Park, K. C., Choi, H., Choi, J., Park, S.-R., Lee, I., & Lee, H. (2014) · Tissue Engineering and Regenerative Medicine · doi:10.1007/s13770-014-0043-6 · Cited by 4
Connection re-established: neurotransmission between the medial prefrontal cortex and serotonergic neurons offers perspectives for fast antidepressant action
Etiévant, A., Lambás‐Señas, L., Abrial, E., Betry, C., Haddjeri, N., & Lucas, G. (2011) · Neuropsychiatry · doi:10.2217/npy.11.9 · Cited by 7
Hunting for Peripheral Biomarkers to Support Drug Development in Psychiatry
Domenici, E., Muglia, P., & Merlo‐Pich, E. (2008) · Springer eBooks · doi:10.1007/978-0-387-79251-4_16 · Cited by 4
Crossing the Blood-Brain-Barrier: A bifunctional liposome for BDNF gene delivery – A Pilot StudyPreprint
Diniz, D. M., Franzè, S., & Homberg, J. R. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.06.25.171264 · Cited by 7
Role of brain-derived neurotrophic factor in the molecular neurobiology of major depressive disorder.
Zhang, Y., Shi, J., Li, J., Liu, R., Yu, Y., & Xu, Y. (2017) · PubMed · Cited by 4
AMPK activation improves depression-like symptoms in olfactory bulbectomized mice by regulating microglia M1/M2 polarization in the hippocampus
Odaira-Satoh, T., Nakagawasai, O., Takahashi, K., Shimada, M., Nemoto, W., & Tan–No, K. (2025) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2025.101008 · Cited by 4
Brain changes associated with thromboxane receptor antagonist SQ 29,548 treatment in a mouse model
Rebel, A. A., Urquhart, S. A., Puig, K. L., Ghatak, A., Brose, S. A., Golovko, M. Y., & Combs, C. K. (2015) · Journal of Neuroscience Research · doi:10.1002/jnr.23578 · Cited by 3
Race-Dependent Association of Single-Nucleotide Polymorphisms in TrkB Receptor in People Living with HIV and Depression
Avdoshina, V., Yumoto, F., Mocchetti, I., Letendre, S. L., & Tractenberg, R. E. (2021) · Neurotoxicity Research · doi:10.1007/s12640-021-00406-1 · Cited by 2
The use of neuroprotectors in the treatment of late depression
Сафарова, Т. П., & Si, G. (2020) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro202012010246 · Cited by 3
Récidives dépressives : modifications cognitives et neuroplasticité
Vidailhet, P. (2010) · L Encéphale · doi:10.1016/s0013-7006(10)70047-6 · Cited by 3
Exploring the Impact of Modifiable Factors on Serum BDNF in Psychiatric Patients and Community Controls
Chan, G., Rosic, T., Pasyk, S., Dehghan, M., & Samaan, Z. (2021) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s295026 · Cited by 3
Mapping of Nervous System Diseases via MicroRNAs
(2016) · CRC Press eBooks · doi:10.1201/b19229 · Cited by 3
Depression and antidepressant action—from molecules to networks
Rantamäki, T., & Yalçın, İ. (2019) · Cell and Tissue Research · doi:10.1007/s00441-019-03042-6 · Cited by 3
Prognostic Significance of Blood Brain-Derived Neurotrophic Factor (BDNF) in the Treatment of Various Functional and Organic Nervous System Diseases with Adaptol
Живолупов, С. А., Samartsev, I. N., Марченко, А. А., & Pulyatkina, O. V. (2013) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-013-9820-2 · Cited by 2
Changes in RNA expression levels during antidepressant treatment: a systematic review
Kim, H. K., Zai, G. C., Hennings, J. M., Müller, D. J., & Kloiber, S. M. (2021) · Journal of Neural Transmission · doi:10.1007/s00702-021-02394-0 · Cited by 2
Pharmacotherapy to prevent the onset of depression following traumatic brain injury
Fornaro, M., Trinchillo, A., Saccà, F., Iasevoli, F., Nolano, M., & de Bartolomeis, A. (2021) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2021.1980537 · Cited by 2
Neurotrophins and Neurotrophic Therapy (Based on the Cerebrolysin Model) in the Treatment of Elderly Patients with Cognitive Disorders and Depression. Part 2
Si, G., & Сафарова, Т. П. (2021) · Psikhiatriya · doi:10.30629/2618-6667-2021-19-3-80-89 · Cited by 2
Methylmercury Exposure and Developmental Neurotoxicity: New Insights from Neural Stem Cells
Bose, R., Spulber, S. D., & Ceccatelli, S. (2022) · Springer eBooks · doi:10.1007/978-3-031-15080-7_235 · Cited by 2
Omega-3 Fatty Acids and Ageing Brain
Boga, N. S., & Basak, S. (2023) · Springer eBooks · doi:10.1007/978-981-99-0534-8_6 · Cited by 2
Etiopathogenesis of depression and experimental depression models used in preclinical studies
Kandemir, Ü. (2023) · European Journal of Life Sciences · doi:10.55971/ejls.1327521 · Cited by 2
Ni and Al mixture amplifies cerebellar oxido-inflammatory responses, down regulates AChE and BDNF/NGF levels in motor impairment in male albino rats
Anyachor, C. P., Orish, C. N., Ezejiofor, A. N., Ćirović, A., Ćirović, A., Ezealisiji, K. M., Patrick-Iwuanyanwu, K. C., Venkatesh, T., & Orisakwe, O. E. (2023) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2023.127318 · Cited by 3
Antidepressant effect of globin digest through enhanced hippocampal neurogenesis in a mouse model of lipopolysaccharide-induced depression
Nakagawasai, O., Yamada, K., Takahashi, K., Niinuma, F., Nemoto, W., & Tan–No, K. (2025) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2025.01.008 · Cited by 2
Factor neurotrófico derivado del cerebro como marcador de conducta suicida en pacientes con trastorno depresivo mayor
Daniel Silva, N., Benjamín Vicente, P., & Mario Valdivia, P. (2015) · Revista chilena de neuro-psiquiatría · doi:10.4067/s0717-92272015000100006 · Cited by 6
Neurotrophic Factors and Depression: Pathophysiology and Beyond
Gümrü, S., & Arıcıoğlu, F. (2012) · Cited by 2
Neurobiología de la depresión
Sequeira‐Cordero, A., & Trías, J. F. (2009) · Americanae (AECID Library) · Cited by 2
Current state and potential of pharmacogenetic studies in the treatment of depression
Ivanets, N. N., Tikhonova, Y. G., Kinkulkina, M. A., & Avdeeva, T. I. (2015) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro201511531113-121 · Cited by 2
RESTORATION OF MOTOR AND NON-MOTOR FUNCTIONS BY NEUROTROPHIC FACTORS IN NONHUMAN PRIMATES WITH DOPAMINE DEPLETION
Subramanian, K. (2013) · D-Scholarship@Pitt (University of Pittsburgh) · Cited by 2
Biochemical Markers
Lee, B.-H., & Kim, Y. (2016) · Springer eBooks · doi:10.1007/978-3-319-26282-6_13 · Cited by 2
Enigmas in Psychiatry
Chee, K.-T., Lee, T.-S. W., & Ng, B.-Y. (2009) · Annals of the Academy of Medicine Singapore · doi:10.47102/annals-acadmedsg.v38n5p447 · Cited by 2
Brain-Derived Neurotrophic Factor (BDNF) in Depression: A Mini Review of Clinical and Preclinical Evidence
Thornton, O. R. (2023) · International Neuropsychiatric Disease Journal · doi:10.9734/indj/2023/v20i3399 · Cited by 3
Gene-Environment Interactions, Stress, and Depression
Cohen‐Woods, S., & Harkess, K. N. (2016) · Springer eBooks · doi:10.1007/978-981-4560-53-5_41-2 · Cited by 2
Ações terapêuticas da geleia real
Bezerra, A. L. D., de Sousa, M. N. A., Santos, E. V. D. L., de Medeiros, A. C., & Maracajá, P. B. (2018) · Revista Brasileira de Educação e Saúde · doi:10.18378/rebes.v8i4.6323 · Cited by 2
Mechanisms and Effects of Dietary Restriction on CNS and Affective Disorders
Haritov, E., Garalova, M., Tivcheva, Y., Angelov, T., & Stamenov, V. (2020) · Acta Medica Bulgarica · doi:10.2478/amb-2020-0025 · Cited by 2
How Can Stress Alter Emotional Balance Through Its Interaction with the Serotonergic System?
Mongeau, R., Hamon, M., & Lanfumey, L. (2011) · Wiley eBooks · doi:10.1002/9781118083222.ch24 · Cited by 2
From non-pharmacological interventions to therapeutic targets for the treatment of PTSD
Hendriksen, H. M. A. (2012) · Utrecht University Repository (Utrecht University) · Cited by 2
Specific Mental Health Disorders: Depressive and Anxiety Disorders
Hickie, I. B. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803678-5.00425-2 · Cited by 2
Homocysteine modulates social isolation-induced depressive-like behaviors through BDNF in aged micePreprint
Wei, W.-D., Lan, Y.-X., Lu, K., Wang, Y., & Chen, W. (2022) · Research Square · doi:10.21203/rs.3.rs-2118589/v1 · Cited by 2
The Role of Brain-Derived Neurotrophic Factor (BDNF) in Depression: A Narrative Review
Varghese, T. P., Singh, R., & Chand, S. (2025) · The Open Biomarkers Journal · doi:10.2174/0118753183394103250623111239 · Cited by 1
Targeting neuroplasticity in old brain: restoring synapse with cognitive strategies
Kopalli, S. R., Kale, M. B., Yadav, A., Alshahrani, S., Mohammed, A., Oirdi, M. E., Farhan, M., Taksande, B. G., Upaganlawar, A. B., Umekar, M. J., et al. (2026) · Biogerontology · doi:10.1007/s10522-026-10408-1 · Cited by 2
[Depression and neuroplasticity. Interaction of nervous, endocrine and immune systems].
Cassano, P., & Argibay, P. F. (2010) · PubMed · Cited by 2
Key molecules in axon regeneration
Kaselis, A., & Šatkauskas, S. (2013) · Biologija · doi:10.6001/biologija.v59i1.2647 · Cited by 1
Glucocorticoids and stress‐related depression: an evaluation of biological mechanisms and the potential for new therapeutics
McVicar, A. J., & Clancy, J. (2011) · Journal of Public Mental Health · doi:10.1108/17465721111134529 · Cited by 1
The Effects of Exercise on the Mental Health
Alikhani, A., Mojtaba, M., & Amiri, S. (2015) · International Journal of Advanced Biological and Biomedical Research · Cited by 1
Brain Networks, Hormones and Genes Implicated in Depression
Bennett, M. R. (2012) · Springer eBooks · doi:10.1007/978-94-007-5748-6_5 · Cited by 1
Advances in Relationship Between Brain-derived Neurotrophic Factor and Depressive Disorder*
Zhou, X., Hu, Y., & Ping, L. I. U. (2012) · PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS · doi:10.3724/sp.j.1206.2011.00095 · Cited by 1
The Role of Arrestins in the Neuroprotective Effects of Antidepressant Drugs
Avissar, S., Golan, M., Feinshtein, V., Kolatkar, S., Fux, D., & Schreiber, G. (2016) · Springer eBooks · doi:10.1007/978-81-322-2803-5_46 · Cited by 1
The Role of BDNF in Depression
Elzinga, B. M., Penninx, B. W. J. H., Spinhoven, P., & Molendijk, M. L. (2008) · Cited by 1
Stream of consciousness: Quantum and biochemical assumptions regarding psychopathology
Tonello, L., Cocchi, M., Gabrielli, F., & Tuszyński, J. A. (2017) · Medical Hypotheses · doi:10.1016/j.mehy.2017.02.013 · Cited by 2
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Authors: CASTREN, E., VOIKAR, V, & RANTAMAKI, T.
Venue: Current Opinion in Pharmacology
Publisher: Elsevier BV
Published: 2007-02
Volume: 7
Issue: 1
Pages: 18-21
ISSN: 1471-4892 (ISSN-L)
DOI: 10.1016/j.coph.2006.08.009
OpenAlex: W1993636230
Cited by: 667
References: 32
Citations by year: 2026: 8 · 2025: 18 · 2024: 17 · 2023: 20 · 2022: 13 · 2021: 24 · 2020: 30 · 2019: 23 · 2018: 31 · 2017: 32 · 2016: 33 · 2015: 57 · 2014: 38 · 2013: 40 · 2012: 59
FWCI: 25.55
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Current Opinion in Pharmacology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: neurotrophic factors, major depressive disorder, brain-derived neurotrophic factor, antidepressant mechanism, hippocampus, prefrontal cortex, neuroplasticity, neurogenesis, synaptogenesis, chronic stress, chromatin structure, mesolimbic dopamine system, activity-dependent plasticity, mood disorders
MeSH terms: Animals, Antidepressive Agents, Depression, Humans, Nerve Growth Factors, Stress, Physiological, Mood Disorders

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