Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants
Abstract
Background Because researchers have reported that antidepressants increase the expression of brain-derived neurotrophic factor (BDNF) in the rat hippocampus, we investigated whether serum BDNF levels may be used as a putative biological marker for major depressive disorders (MDD).Methods We measured serum BDNF in the following three groups: antidepressant-naive patients with MDD (n = 16), antidepressant-treated patients with MDD (n = 17), and normal control subjects (n = 50). Patients were evaluated using the Hamilton Rating Scale for Depression (HAM-D). Serum BDNF was assayed with the sandwich ELISA method.Results We found that serum BDNF was significantly lower in the antidepressant-naive group (mean, 17.6 ng/mL; SD, 9.6) than in the treated (mean, 30.6 ng/mL; SD, 12.3; p =.001) or in the control group (mean, 27.7 ng/mL; SD, 11.4; p =.002). There was a significant negative correlation (r = -.350, z = -2.003, p =.045) between serum BDNF and HAM-D scores in all patients. In a preliminary examination, reduced BDNF values of three drug-naive patients recovered to basal levels after antidepressant treatment.Conclusions Our study suggests that low BDNF levels may play a pivotal role in the pathophysiology of MDD and that antidepressants may increase BDNF in depressed patients.
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Both MDD patients and animal models of depression show a remarkable reduction in serum BDNF levels.
“Both MDD patients [57–59] and animal models of depression [60, 61] show a remarkable reduction in serum BDNF levels.”
From Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation (2019) · cites this paper as [59]
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- Authors
- Shimizu, E., Hashimoto, K., Okamura, N., Koike, K., Komatsu, N., Kumakiri, C., Nakazato, M., Watanabe, H., Shinoda, N., Okada, S.-I., & Iyo, M.
- Affiliations
- Chiba University (JP)
- Corresponding author
- Shimizu, Eiji
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2003-07
- Volume
- 54
- Issue
- 1
- Pages
- 70-75
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W1968213313
- Cited by
- 1,151
- References
- 37
- Citations by year
- 2026: 16 · 2025: 17 · 2024: 21 · 2023: 30 · 2022: 33 · 2021: 53 · 2020: 41 · 2019: 54 · 2018: 50 · 2017: 43 · 2016: 66 · 2015: 64 · 2014: 80 · 2013: 78 · 2012: 65
- FWCI
- 23.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Keywords
- brain-derived neurotrophic factor, serum BDNF, major depressive disorder, antidepressant treatment, depression biomarkers, depression pathophysiology, depression severity
- MeSH terms
- Adult, Aged, Antidepressive Agents, Major Depressive Disorder, Depressive Disorder, Major, Enzyme-Linked Immunosorbent Assay, Female, Humans, Male, Middle Aged, Biomarkers, Case-Control Studies, Brain-Derived Neurotrophic Factor
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