Effects of the renin angiotensin system on vasculogenesis-related progenitor cells
Abstract
The current concept is that there are both cells that integrate into the vasculature, true endothelial progenitor cells (EPC), and cells with hematopoietic markers that support neovascularisation. As identification of the EPC is controversial and studies refer cells that might fall into either pools, we will use the term, vasculogenesis-related progenitor cells (VRPC), for this review. VRPC are considered to be an important target for the treatment of cardiovascular diseases (CVD). Angiotensin II is known to be an important player in neovascularisation and the modulation of renin angiotensin system (RAS) is one of the major pharmacotherapeutic strategies for the treatment of CVD. We will review the effects of different components of the RAS on such VRPC under physiological conditions and in CVD. The reviewed research strongly supports a critical role of the RAS in vasculogenesis and vascular regeneration. Therefore, pharmacological intervention on the components of the RAS does not only target directly end-organ remodelling and blood pressure but also influence tissue healing and/or regeneration by influencing specific progenitor cells. Thus, the interrogation of RAS effects on VRPC will be important in the optimisation of RAS intervention or regenerative therapy.
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Local RAS is key to regulating repair and regeneration in epidermal and vasculogenesis-related progenitor cells.
“Local RAS has been proved to be the key to regulating repair and regeneration in epidermal and vasculogenesis related progenitor cells [8, 9].”
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- Authors
- Roks, A. J., Rodgers, K., & Walther, T.
- Affiliations
- Erasmus MC (NL)
- University of Southern California (US)
- University of Hull (GB)
- Corresponding author
- Walther, Thomas
- Venue
- Current Opinion in Pharmacology
- Publisher
- Elsevier BV
- Published
- 2011-04
- Volume
- 11
- Issue
- 2
- Pages
- 162-174
- ISSN
- 1471-4892 (ISSN-L)
- OpenAlex
- W2052200425
- Cited by
- 26
- References
- 87
- Citations by year
- 2024: 5 · 2023: 1 · 2022: 2 · 2020: 1 · 2019: 1 · 2017: 4 · 2016: 3 · 2015: 1 · 2014: 1 · 2013: 2 · 2012: 3
- FWCI
- 0.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
- Keywords
- renin-angiotensin system, endothelial progenitor cells, angiotensin II, neovascularization, vascular regeneration, cardiovascular disease, regenerative therapy
- MeSH terms
- Angiotensin-Converting Enzyme Inhibitors, Angiotensins, Animals, Cardiovascular Diseases, Disease Models, Animal, Hematopoiesis, Humans, Renin-Angiotensin System, Stem Cells, Reactive Oxygen Species, Neovascularization, Physiologic, Endothelial Cells, Angiotensin Receptor Antagonists
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