Decoding cell type diversity within the spinal cord
Open accessAbstract
To understand fundamental mechanisms of mammalian spinal cord function, it is necessary to reveal the diverse array of constituent spinal "cell types" - populations that can be consistently identified because they share a unique and cohesive set of characteristics. Many parameters can contribute to the definition of a spinal cord cell type, including location, morphology, lineage, electrophysiological properties, circuit features, gene expression patterns, and behavioral contribution. While it is not necessary for all of these features to align completely at all times to identify an individual cell type, a correlation of these characteristics paints a rich portrait of cell identity. This review will summarize recent advances in the identification of mammalian spinal cord neuronal cell types and will highlight the power of transcriptional profiling to identify and characterize the cell types of the spinal cord.
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There is still no consensus cell type atlas of the spinal cord.
“These studies provide a powerful and multi-faceted perspective on spinal cord cell types, yet despite this significant effort and a rich literature of spinal cord cell type characterization (see reviews12–19), there is still no consensus cell type atlas of the spinal cord20.”
From A harmonized atlas of mouse spinal cord cell types and their spatial organization (2021) · cites this paper as [20]
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References 48 · Cited by 26
- Authors
- Dobrott, C. I., Sathyamurthy, A., & Levine, A. J.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Levine, Ariel J
- Venue
- Current Opinion in Physiology
- Publisher
- Elsevier BV
- Published
- 2019-04
- Volume
- 8
- Pages
- 1-6
- ISSN
- 2468-8673 (ISSN-L)
- PMC
- PMC6768067
- OpenAlex
- W2903297071
- Cited by
- 26
- References
- 48
- Citations by year
- 2026: 1 · 2025: 4 · 2023: 2 · 2022: 9 · 2021: 7 · 2020: 2 · 2019: 1
- FWCI
- 0.25
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Physiology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health Intramural Research Program
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Single-cell and spatial transcriptomics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- spinal cord, neuronal cell types, cell identity, gene expression profiling, gene expression, cell lineage, electrophysiological properties, circuit function, cell type diversity
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