Dysfunctional reward processing in depression
Open accessAbstract
Anhedonia - diminished pleasure and/or decreased reactivity to pleasurable stimuli - is a core feature of depression that frequently persists after treatment. As a result, extensive effort has been directed towards characterizing the psychological and biological processes that mediate dysfunctional reward processing in depression. Reward processing can be parsed into sub-components that include motivation, reinforcement learning, and hedonic capacity, which, according to preclinical and neuroimaging evidence, involve partially dissociable brain systems. In line with this, recent findings indicate that behavioral impairments and neural abnormalities in depression vary across distinct reward-related constructs. Ultimately, improved understanding of precise reward-related dysfunctions in depression promises to improve diagnostic and therapeutic efforts in depression.
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People with depression frequently experience anhedonia, which may result in blunted sensitivity to reward.
“People with depression frequently experience anhedonia, which may result in blunted sensitivity to reward [11-15].”
From Examining the effectiveness of gamification in mental health apps for depression: Systematic review and meta-analysis (2021) · cites this paper as [11]
Depression generally has been associated with hyposensitivity to rewards, particularly among those with anhedonic symptoms.
“Depression generally has been associated with hyposensitivity to rewards, particularly among those with anhedonic symptoms [11-13,16,17].”
From Examining the effectiveness of gamification in mental health apps for depression: Systematic review and meta-analysis (2021) · cites this paper as [11]
Deficits in reward processing occur in major depressive disorder, substance use disorders, posttraumatic stress disorder, schizophrenia, and ADHD.
“Deficits in reward processing are found in MDD (Admon and Pizzagalli, 2015), substance use disorders (Garfield et al., 2014; Tobler et al., 2016), posttraumatic stress disorder (PTSD) (Kalebasi et al., 2015), schizophrenia (McCarthy et al., 2016), and ADHD (van Hulst et al., 2016).”
From The effects of early life stress on reward processing (2018) · cites this paper as Admon and Pizzagalli, 2015
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References 50 · Cited by 343
- Authors
- Admon, R., & Pizzagalli, D. A.
- Affiliations
- Harvard University (US)
- Corresponding author
- Pizzagalli, Diego A
- Venue
- Current Opinion in Psychology
- Publisher
- Elsevier BV
- Published
- 2015-08
- Volume
- 4
- Pages
- 114-118
- ISSN
- 2352-250X (ISSN-L)
- PMC
- PMC4525714
- OpenAlex
- W2043639603
- Cited by
- 343
- References
- 50
- Citations by year
- 2026: 39 · 2025: 47 · 2024: 39 · 2023: 39 · 2022: 36 · 2021: 40 · 2020: 31 · 2019: 30 · 2018: 18 · 2017: 11 · 2016: 11 · 2015: 2
- FWCI
- 1.39
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Psychology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Brain and Behavior Research Foundation (R01 MH101521, R01 MH068376, R01 MH095809)
- National Institute of Mental Health (R01 MH101521, R01 MH068376, R01 MH095809)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- depression, reward processing, anhedonia, motivation, reinforcement learning, hedonic capacity, persistent depressive symptoms
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