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Cited by 314

The DOI matches its Crossref record; 101 of the 101 references it cites were found in a registry or an index.

Induction and function of type I and III interferon in response to viral infection

Open access
Levy, David E, Marié, Isabelle J, Durbin, Joan E·2011·Current Opinion in Virology

Abstract

The type I and III interferon (IFN) families consist of cytokines rapidly induced during viral infection that confer antiviral protection on target cells and are critical components of innate immune responses and the transition to effective adaptive immunity. The regulation of their expression involves an intricate and stringently regulated signaling cascade, initiated by recognition most often of viral nucleic acid in cytoplasmic and endosomal compartments and involving a series of protein conformational rearrangements and interactions regulated by helicase action, ubiquitin modification, and protein aggregation, culminating in kinase activation and phosphorylation of critical transcription factors and their regulators. The many IFN subtypes induced by viruses confer amplification, diversification, and cell-type specificity to the host response to infection, providing fertile ground for development of antiviral therapeutics and vaccines.

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Crossref · 10.1016/j.coviro.2011.11.001

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Metadata

Authors
Levy, D. E., Marié, I. J., & Durbin, J. E.
Venue
Current Opinion in Virology
Publisher
Elsevier BV
Published
2011-12
Volume
1
Issue
6
Pages
476-486
ISSN
1879-6257 (ISSN-L)
OpenAlex
W1965154773
Cited by
314
References
101
FWCI
1.16
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Induction and function of type I and III interferon in response to viral infection. https://app.cochat.ai/papers/10.1016/j.coviro.2011.11.001
The paper
Levy, D. E., Marié, I. J., & Durbin, J. E. (2011). Induction and function of type I and III interferon in response to viral infection. Current Opinion in Virology. https://doi.org/10.1016/j.coviro.2011.11.001

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.