The role of receptor binding specificity in interspecies transmission of influenza viruses

Imai, Masaki; Kawaoka, Yoshihiro

doi:10.1016/j.coviro.2012.03.003

Cited by 312Influenza Virus Research StudiesVirology and Viral DiseasesViral Infections and Outbreaks Research

The role of receptor binding specificity in interspecies transmission of influenza viruses

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Imai, Masaki, Kawaoka, Yoshihiro·2012·Current Opinion in Virology

DOI 10.1016/j.coviro.2012.03.003PMC PMC5605752

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Abstract

Influenza A virus infection begins with the binding of the hemagglutinin (HA) glycoprotein to sialic acid-containing receptors on the surface of the target cell. Avian influenza viruses, including avian H5N1, H7, and H9N2 viruses, can occasionally cross the species barrier and infect humans; however, these viruses do not spread efficiently from person to person, perhaps, partly, owing to differences in the receptor-binding specificities of human and avian influenza viruses. The HAs of avian influenza viruses must adapt to receptors in humans to acquire efficient human-to-human transmissibility. In this review, we discuss the receptor binding specificity of influenza A viruses and its role in interspecies transmission.

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Typically, the influenza virus binds to α2,6-linked sialic acid and α2,3-linked sialic acid found on epithelial cells of the upper and lower respiratory tract.
“Typically, the virus binds to α2,6-linked sialic acid and α2,3-linked sialic acid found on epithelial cells of the upper and lower respiratory tract [92].”
From Viral meningitis: an overview (2021) · cites this paper as [92]
The receptor-binding specificity section says influenza HA binds sialic-acid-containing glycans on epithelial cells, but distinguishes human strains, which preferentially bind α2,6-linked receptors, from avian strains, which prefer α2,3-linked receptors. It reports predominantly α2,6-linked receptors in the human upper respiratory tract; it does not establish the claimed receptor distribution in the lower respiratory tract. (LLM, conf=0.86)
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Authors: Imai, M., & Kawaoka, Y.
Affiliations: National Institute of Infectious Diseases (JP)
University of Wisconsin–Madison (US)
Corresponding author: Kawaoka, Yoshihiro
ORCID: Imai, Masaki
Kawaoka, Yoshihiro
Venue: Current Opinion in Virology
Publisher: Elsevier BV
Published: 2012-04
Volume: 2
Issue: 2
Pages: 160-167
ISSN: 1879-6257 (ISSN-L)
DOI: 10.1016/j.coviro.2012.03.003
PMC: PMC5605752
OpenAlex: W1991581164
Cited by: 312
References: 69
Citations by year: 2026: 10 · 2025: 15 · 2024: 15 · 2023: 8 · 2022: 16 · 2021: 15 · 2020: 41 · 2019: 30 · 2018: 11 · 2017: 15 · 2016: 23 · 2015: 33 · 2014: 33 · 2013: 39 · 2012: 8
FWCI: 4.51
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Current Opinion in Virology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Allergy and Infectious Diseases (R01AI069274)
Topics: Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
Health Sciences › Medicine › Infectious Diseases › Viral Infections and Outbreaks Research
Keywords: influenza A virus, hemagglutinin, receptor specificity, sialic acid receptors, interspecies transmission, avian influenza, H5N1, H7, H9N2, human-to-human transmission, receptor adaptation
MeSH terms: Animals, Birds, Influenza in Birds, Humans, Influenza, Human, Influenza A virus, Protein Binding, Receptors, Virus, Species Specificity

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The role of receptor binding specificity in interspecies transmission of influenza viruses

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