The importance of functional impairment to mental health outcomes: a case for reassessing our goals in depression treatment research

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1. A Randomized Evaluation of MoodFX, a Patient-Centred e-Health Tool to Support Outcome Measurement for Depression: Une évaluation randomisée de MoodFX, un outil de santé en ligne centré sur le patient pour soutenir la mesure du résultat dans la dépression.
   Li, Victor W., Sahota, Jaspreet, Dev, Deea K., Gill, Dib D., Evans, Vanessa C., Axler, Auby, Chakrabarty, Trisha, Do, André, Keramatian, Kamyar, Nunez, John-Jose et al. · 2024 · The Canadian Journal of Psychiatry
2. The relationship between expressive suppression, therapeutic bond, and treatment outcomes of a positive affect intervention for adults with anxiety and/or depression
   Samantha N. Hoffman, Murray B. Stein, Charles T. Taylor · 2024 · Cognitive Behaviour Therapy
3. The Work and Social Adjustment Scale (WSAS): An investigation of reliability, validity, and associations with clinical characteristics in psychiatric outpatients
   Jakob Lundqvist, Martin Schevik Lindberg, Martin Brattmyr, Audun Havnen, Odin Hjemdal, Stian Solem · 2024 · PLoS ONE
4. Associations between eating disorder symptoms, employment status, and occupational functioning among female veterans
   Megan E. Sienkiewicz, Katherine M. Iverson, Brian Neil Smith, Karen S. Mitchell · 2021 · Eating Behaviors
5. Bidirectional changes in depressive symptoms and social functioning in older adults attending psychological therapy services
   Thomas Steare, Joshua E. J. Buckman, Joshua C. H. Stott, Amber John, Satwant Singh, Jon Wheatley, Stephen Pilling, Rob Saunders · 2024 · Journal of Affective Disorders
6. Asking patients about their general level of functioning: Is IT worth IT for common mental disorders?
   Elena Olariu, Carlos G. Forero, Pilar Álvarez, José Ignacio Castro-Rodríguez, María Jesús Blasco, Jordi Alonso · 2015 · Psychiatry Research
7. Motivation and Social Relations in School Following a CBT Course for Adolescents With Depressive Symptoms: An Effectiveness Study
   Margit Garvik, Thormod Idsøe, Edvin Bru · 2015 · Scandinavian Journal of Educational Research
8. Getting Back to Work: Cognitive Behavioral Predictors of Depressive Symptoms and Job Search Success
   Benjamin J. Pfeifer, Daniel R. Strunk · 2016 · Journal of Clinical Psychology
9. Getting down to business: an examination of occupational outcomes in cognitive behavioral therapy for depression
   Iony D. Ezawa, Graham C. Bartels, Daniel R. Strunk · 2021 · Cognitive Behaviour Therapy
10. Interview and questionnaire assessment of cognitive impairment in subjects at ultra-high risk for psychosis: Associations with cognitive test performance, psychosocial functioning, and positive symptoms
    Lasse Randers, Birgitte Fagerlund, Jens Richardt M. Jepsen, Dorte Nordholm, Kristine Krakauer, Carsten Rygaard Hjorthøj, Birte Yding Glenthoj, Merete Nordentoft · 2020 · Psychiatry Research
11. Drug development in psychopharmacology: Insights from evolutionary psychiatry
    Alfonso Troisi · 2024 · Neuroscience & Biobehavioral Reviews
12. An exploratory qualitative assessment of patient and clinician perspectives on patient-reported outcome measures and disease-modifying therapies in adults with spinal muscular atrophy
    Jeremy Slayter, Lauren Casey, Shane A. McCullum, Dorothy Drost, Allison Banks, Colleen M. O’Connell · 2025 · Journal of Rehabilitation Medicine
13. Redefining Therapeutic Outcomes of Depression Treatment
    Christien Slofstra, Sanne Henrieke Booij, Rogier H. J. Hoenders, Stynke Castelein · 2019 · Journal for Person-Oriented Research
14. Displacement as a predictor of functional impairment in tsunami-exposed children.
    Christian K. Lee, Ye Beverly Du, Desy Christina, J. Palfrey, E. O'Rourke, M. Belfer · 2015 · Disasters. The Journal of Disaster Studies, Policy and Management
15. Work stressors, depressive symptoms and sleep quality among US Navy members: a parallel process latent growth modelling approach across deployment
    Adrian Jorge Bravo, Michelle L. Kelley, Cindy M. Swinkels, Christi S. Ulmer · 2017 · Journal of Sleep Research
16. Change in functioning outcomes as a predictor of the course of depression: a 12-month longitudinal study
    INSAyD Investigators, Carlos G. Forero, Elena Olariu, Pilar Álvarez, José Ignacio Castro-Rodríguez, María Jesús Blasco, Gemma Vilagut, Víctor Pérez, Jordi Alonso · 2018 · Quality of Life Research
17. Predictors of General Functioning and Correlates of Quality of Life: A Cross-Sectional Study among Psychiatric Outpatients
    Louisa Picco, Ying Wen Lau, Shirlene Pang, Anitha Jeyagurunathan, Janhavi Ajit Vaingankar, Edimansyah Abdin, Siow Ann Chong, Mythily Subramaniam · 2018 · Annals of the Academy of Medicine Singapore
18. Advancements in the molecular understanding of major depressive disorder uncovering novel targets with therapeutic promise: focus on recurrence of illness
    Michael H. J. Maes, Abbas Firras Almulla, Drozdstoy Stoyanov, Yingqian Zhang · 2025 · Expert Opinion on Therapeutic Targets
19. Does moderate to vigorous physical activity mediate the association between depression and physical function in midlife: Evidence from two British birth cohort studies
    Joanna M. Blodgett, Tom Norris, Snehal M. Pinto Pereira, Mark Hamer · 2022 · Journal of Affective Disorders
20. Application of an egocentric social network approach to examine changes in social connections following treatment for anxiety and depression: A novel measurement tool for clinical trials research?
    Madeleine M. Rassaby, Holly Baker Shakya, James H. Fowler, Christopher Oveis, William J. Sieber, Sonia Jain, Murray B. Stein, Charles T. Taylor · 2024 · Social Science & Medicine
21. Leaving the gang is good for your health: A stress process perspective on disengagement from gangs
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22. Beyond Response: Aiming for Quality Remission in Depression
    Sidney H. Kennedy · 2022 · Advances in Therapy
23. Assessing the impact of mental health difficulties on young people’s daily lives: protocol for a scoping umbrella review of measurement instruments
    Karolin Rose Krause, Sophie Chung, Terri Rodak, Kristin Cleverley, Nancy J. Butcher, Péter Szatmári · 2022 · BMJ Open
24. Which complex PTSD symptoms predict functional impairment in females with comorbid personality disorder needs? Research and treatment implications
    Elanor Lucy Webb, Deborah J. Morris, Emily J. Watson, Emily Fox, Vicky Sibley, Victoria Taylor · 2022 · European Journal of Trauma & Dissociation
25. Investigating pathways from anxiety sensitivity to impairment in a treatment-seeking sample
    Janine V. Olthuis, Kara Thompson, Margo C. Watt, Sherry H. Stewart · 2022 · Journal of Affective Disorders
26. Unraveling the associations between unhealthy lifestyle behaviors and mental health in the general adult Chinese population: A cross-sectional study
    Vincent Wing-Hei Wong, Eric Kwok Lun Yiu, Chee H. Ng, Jerome J. Sarris, Fiona Yan‐Yee Ho · 2024 · Journal of Affective Disorders
27. The effects of levomilnacipran ER in adult patients with first-episode, highly recurrent, or chronic MDD
    Susan G. Kornstein, Carl Gommoll, Changzheng Chen, Kenneth L. Kramer · 2015 · Journal of Affective Disorders
28. Using a hybrid subtyping model to capture patterns and dimensionality of depressive and anxiety symptomatology in the general population
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29. The Relationship between Symptom Relief and Psychosocial Functional Improvement during Acute Electroconvulsive Therapy for Patients with Major Depressive Disorder
    Ching‐Hua Lin, Wei‐Cheng Yang · 2017 · The International Journal of Neuropsychopharmacology
30. Clinical Switching Strategies of Various Antidepressants to Vortioxetine in the PREDDICT Trial
    Natalie T. Mills, Emma Sampson, Célia Fourrier, Bernhard Theodor Baune · 2020 · The International Journal of Neuropsychopharmacology
31. Relationships between reduction in symptoms and restoration of function and wellbeing: Outcomes of the Oral Ketamine Trial on Suicidality (OKTOS)
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32. A Psychometric Analysis of the Spanish Version of the Grief Impairment Scale: A Screening Tool of Biopsychosocial Grief-Related Functional Impairment in a Salvadoran Sample
    Tomás Caycho‐Rodríguez, Sherman Aclaracion Lee, Lindsey W. Vilca, Marlon Elías Lobos-Rivera, Angélica Nohemy Flores-Monterrosa, Jennyfer Carolina Tejada Rodríguez, Edgardo René Chacón-Andrade, Wendy Carolina Marroquín-Carpio, Carlos Carbajal‐León, Mario Alexander Reyes-Bossio et al. · 2023 · OMEGA - Journal of Death and Dying
33. Physical functioning after occupational rehabilitation and returning to work among employees with chronic musculoskeletal pain and comorbid depressive symptoms
    Linda Ernstsen, Monica Lillefjell · 2014 · Journal of Multidisciplinary Healthcare
34. Effects of levomilnacipran ER on noradrenergic symptoms, anxiety symptoms, and functional impairment in adults with major depressive disorder: Post hoc analysis of 5 clinical trials
    Pierre Blier, Carl Gommoll, Changzheng Chen, Kenneth L. Kramer · 2016 · Journal of Affective Disorders
35. Mental health and the NDIS: A literature review
    Angela Nicholas, Lennart Reifels, Kelly M. King, Sarah Pollock · 2014 · Minerva Access (University of Melbourne)
36. A network approach to climate change anxiety and its key related features
    Alexandre Heeren, Camille Mouguiama-Daouda, Richard J. McNally · 2022
37. Functional outcomes with bright light in monotherapy and combined with fluoxetine in patients with major depressive disorder: Results from the LIFE-D trial
    Li, Victor W., Morton, Emma, Michalak, Erin E., Tam, Edwin M., Levitt, Anthony J., Levitan, Robert D., Cheung, Amy, Morehouse, Rachel, Ramasubbu, Rajamannar, Yatham, Lakshmi N. et al. · 2022 · Journal of Affective Disorders
38. Efficacy of pharmacogenetic (PGx)-guided antidepressant treatment on functional outcomes and quality of life in adults with anxiety and affective disorders: A systematic review and meta-analysis
    Natalia E. Fares‐Otero, Monika Budde, Jonathan Laatsch, Mathias Harrer, Teuntje A. D. Pelgrim, Alexandra Philipsen, Urs Heilbronner, Eduard Vieta, Roos van Westrhenen · 2025 · European Neuropsychopharmacology
39. The Impact of Hostility on Quality of Life, Functioning, and Suicidal Ideation Among Male Veterans with Posttraumatic Stress Disorder
    Stephanie Y. Wells, Carolyn L. Brennan, Elizabeth E. Van Voorhees, Jean C. Beckham, Patrick S. Calhoun, Carolina P. Clancy, Michael A. Hertzberg, Kirsten H. Dillon · 2021 · Journal of Traumatic Stress
40. Storytelling and training to advance individual recovery skills (STAIRS). A feasibility study of a blended program to support personal recovery among patients with a major depressive disorder in remission
    David Wedema, Joanieke Siero, E.L. Korevaar, Klaas J. Wardenaar, Manna Alma, Robert A. Schoevers · 2022 · Frontiers in Psychiatry
41. Assessing the efficacy of the problem management plus (PM+) in improving the mental health of conflict-exposed individuals
    Jelli Grace C. Luzano, Imelu G. Mordeno · 2023 · Current Psychology
42. Does Psychosocial Functioning Improve With Prolonged Exposure in Veterans With PTSD?: Exploring Traditional and Home-Based Telehealth Delivery Methods
    Kristina Reich, Lynne S. Nemeth, Martina Mueller, Lisa Marie Sternke, Ron E. Acierno · 2020 · Journal of Psychosocial Nursing and Mental Health Services
43. Teacher Nominations of Preschool Children at Risk for Mental Health Problems: how False Is a False Positive Nomination and What Make Teachers Concerned?
    Kenneth Stensen, Stian Lydersen, Frode Stenseng, Jan Lance Wallander, May Britt Drugli · 2021 · Journal of Psychopathology and Behavioral Assessment
44. Case Report: Cognitive Work Hardening for Return-to-Work Following Depression
    Adeena Wisenthal · 2021 · Frontiers in Psychiatry
45. Further Exploration of Personal and Social Functioning
    Dalila Talevi, Francesca Pacitti, Manuela Costa, Alessandro Rossi, Alberto Collazzoni, Claudio Crescini, Rodolfo Rossi · 2019 · The Journal of Nervous and Mental Disease
46. Efektivitas Pelatihan Emotional Intelligence untuk Meningkatkan Resiliensi pada Siswi SMP yang Melakukan Self Injury
    Lebda Katodhia, Frikson Christian Sinambela · 2020 · Journal An-Nafs Kajian Penelitian Psikologi
47. Socioeconomic inequalities in impairment associated with depressive symptoms: Evidence from the National Survey on Drug Use and Health
    Regina García Velázquez, Kaisla Komulainen, Kia Gluschkoff, Jaakko Airaksinen, Ilmari Määttänen, Tom Henrik Rosenström, Markus M. Jokela · 2021 · Journal of Psychiatric Research
48. The Depression Impairment Scale for Parents (DISP): A new scale for the measurement of impairment in depressed parents
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49. Association between Levels of cardiorespiratory Fitness and Depressive Symptom in Women
    박세정, JINWOOK CHUNG, Soohyun Park, 김성년, 허지원, 신예슬, Byounggoo Ko, Jun Soo Kwon · 2015 · Exercise Science
50. A Comparative Analysis of Two Gait Training Approaches for Individuals with Transtibial Amputation
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51. From antidepressants and psychotherapy to oxytocin, vagus nerve stimulation, ketamine and psychedelics: how established and novel treatments can improve social functioning in major depression
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52. District Nurses’ Experiences of Practice in Caring for People with Mental Ill-Health in Swedish Primary Care
    Jenny Löyttynen, Ulla Hällgren Graneheim, Åsa Hörnsten · 2023 · Issues in Mental Health Nursing
53. Depressive Disorders
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54. A prognostic model for predicting functional impairment in youth mental health services
    Frank Iorfino, Rafael Oliveira, Sally Cripps, Román Marchant, Mathew Varidel, William Capon, Jacob J. Crouse, Ante Prodan, Elizabeth M. Scott, Jan L. Scott et al. · 2024 · European Psychiatry
55. Functioning in patients with major depression treated with duloxetine or a selective serotonin reuptake inhibitor in East Asia
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56. Psychosocial and physical factors associated with depression in older adults living in studio apartments: A cross-sectional study of a multi-ethnic Asian population
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57. Engaging Patients with Depression in Treatment Continuity
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58. Changes in depression domains as predictors of return to work in common mental disorders
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59. A Dimensional Approach to Measuring Antidepressant Response: Implications for Agomelatine
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60. Social Class and Work Functioning in Treatment for Depression
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61. Impacts on Quality of Life with Escitalopram Monotherapy and Aripiprazole Augmentation in Patients with Major Depressive Disorder: A CAN-BIND Report
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62. Integrating a Dimensional, Hierarchical Taxonomy of Psychopathology into Clinical Practice_
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63. Improving outcome of anxiety and obsessive-compulsive disorders
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64. Payors, Caregivers, and Teens: Aligning Priorities for Effective Digital Mental Health Tools
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65. When Diagnosis Becomes Identity: Navigating the Cultural Inflation of Psychiatric Diagnoses in Nursing Practice
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66. Investigating functional impairment as a mediator of the association between internalising symptoms and low wellbeing
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67. Impact of Collaborative Care on Absenteeism for Depressed Employees Seen in Primary Care Practices
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68. Functional Disability in Psychiatric Patients With Deliberate Self-Harm as Compared to a Clinical Control Group
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69. Symptoms and prevalence of common mental disorders in a heterogenous outpatient sample: an investigation of clinical characteristics and latent subgroups
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70. Measuring the Well-Being of the Whole Person in Clinical Care, Health Research, and Population Health Evaluation
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71. Defining the Evolving Concept of Impairment
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72. Prospective trajectories of depression predict mortality in cancer patients
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73. Therapeutic Focus on Strengths is Associated with Improved Functioning and Higher Clinical Progress in Children’s Public Mental Health Care
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74. The Impact of Two Brief Web-Based Psychological Interventions on Functional Outcomes
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75. Symptom distress and disability: Different sides of the same coin? An investigation of the relationship between symptom distress and disability over time in patients receiving treatment for internalizing disorders
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76. Unmet health care needs in children of parents with poor self-rated mental health: justification for a “think-family” approach
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77. Long-term function and psychosocial outcomes with venlafaxine extended release 75–225 mg/day versus placebo in the PREVENT study
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78. Improving social functioning in depressed mothers: results from a randomised controlled trial
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79. DSM-5-Based ASD Models: Assessing the Latent Structural Relations with Functionality in War-Exposed Individuals
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80. Functional improvement as a treatment goal in major depressive disorder: a narrative review of the evidence for vortioxetine
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81. Enhancing Goal Achievement in Adults With ADHD: A Participant-Centered Evaluation of Transcranial Direct Current Stimulation From the TUNED Trial
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83. Intolerance of uncertainty and climate change experience as driving forces of climate anxiety: Insights from a network perspective
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84. Efficacy of 3,4-methylenedioxymethamphetamine (MDMA)-assisted therapy for posttraumatic stress disorder: A systematic review and meta-analysis of clinical and functional outcomes
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85. Evaluation of psychosocial functioning in the acute treatment term of major depressive disorder: A 16-week multi-centered follow-up study
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86. Randomized Controlled Trials and the Efficacy of Psychotropic Medications
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87. Association Between Personality Traits and Functional Limitations in Older Adults with Affective Disorders: A Cross Sectional Study
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88. Depressive Disorders
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91. Cognitive Orientation to daily Occupational Performance (CO-OP) for mood, anxiety, and adjustment disorders: a pilot study
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92. Work re-entry and functioning in people with major depression: a longitudinal study of supported employment participants
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93. Major Depressive Disorder in Patients With Doctoral Degrees: Patient-reported Depressive Symptom Severity, Functioning, and Quality of Life Before and After Initial Treatment in the STAR*D Study
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94. Baseline physical health-related quality of life and subsequent depression outcomes in cardiac patients.
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95. Levomilnacipran Extended-Release Treatment in Patients With Major Depressive Disorder
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96. Depressive Mood and the Risk of Future Functional Decline in an Elderly Population
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97. Concordance of assessments of clients’ mental and behavioral health with in vivo assessment of work performance
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98. Functional status and its associated factors in Nigerian adults with serious mental illnesses
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99. Exploring Counselor‐Client Agreement on Clients’ Work Capacity in Established and Consultative Dyads
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100. Psychosocial functionality in depressive workers: A study on associated factors
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