The DOI matches its Crossref record; 92 of the 95 references it cites were found in a registry or an index.
A systematic review of predictors and moderators of response to psychological therapies in OCD: Do we have enough empirical evidence to target treatment?
Open accessAbstract
Obsessive-compulsive disorder (OCD) is a disabling mental health condition. Despite effective psychological treatments for OCD, a significant percentage of patients fail to experience lasting benefit. Factors underlying variable treatment response are poorly understood. Moderators of outcome can help understand "for whom" and "under what circumstances" an intervention works best and thus improve service effectiveness. This paper synthesizes the evidence on predictors and moderators and assesses the quality of reporting of related analyses in psychological therapies for adults with OCD. Trials were identified through electronic searches (CENTRAL, MEDLINE, PsycINFO, EMBASE), key author, and reference list searches of relevant systematic reviews. Fifty five percent (38/69) of relevant trials reported baseline factors associated with outcome; these encompassed clinical, demographic, interpersonal, OCD symptom-specific, psychological/psychosocial, and treatment-specific variables. Predictors were commonly assessed via a validated pre-randomization measure, though few trials adopted best practice by stating a priori hypotheses or conducting a test of interaction. Potential associations emerged between worse OCD treatment outcome and the following factors: hoarding pathology, increased anxiety and OCD symptom severity, certain OCD symptom subtypes, unemployment, and being single/not married. However, the applied utility of these analyses is currently limited by methodological weaknesses.
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“And whilst substantial ground has been covered in the adult literature [38–40], this is not the case in treatment for mental disorders in adolescents and young adults [30].”
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“Previous research has recognised the influence of treatment and therapist-related characteristics on treatment outcomes in various disorders, including borderline personality disorder and obsessive-compulsive disorder (Barnicot et al., 2012;Knopp, Knowles, Bee, Lovell, & Bower, 2013).”
From Predictors of outcomes of psychological treatments for disordered gambling: A systematic review (2016) · cites this paper as Knopp et al., 2013
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“While a box-score approach was utilised to synthesise the results, this method is limited by the lack of consideration given to the magnitude of the effect (Green & Hall, 1984;Knopp et al., 2013).”
From Predictors of outcomes of psychological treatments for disordered gambling: A systematic review (2016) · cites this paper as Knopp et al., 2013
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Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
Baron, R. M., & Kenny, D. A. (1986) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.51.6.1173 · Cited by 91,532
Cochrane Handbook for Systematic Reviews of Interventions: Cochrane Book Series
(2008) · doi:10.1002/9780470712184 · Cited by 25,048
Kessler, R. C., Berglund, P., Demler, O., Jin, R., Merikangas, K. R., & Walters, E. E. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.6.593 · Cited by 20,391
Diagnostic and Statistical Manual of Mental Disorders.
Widiger, T. A. (2000) · Oxford University Press eBooks · doi:10.1037/10518-009 · Cited by 19,766
(2000) · Cited by 9,198
Schulz (1995) · doi:10.1001/jama.1995.03520290060030 · Cited by 5,634
Methods of Meta-Analysis: Correcting Error and Bias in Research Findings
Schmidt, F. L., & Hunter, J. E. (2015) · doi:10.4135/9781483398105 · Cited by 5,542
Handbook of Psychotherapy and Behavior Change
Garfield, S. L., Bergin, A. E., & Dryden, W. (1987) · Journal of Cognitive Psychotherapy · doi:10.1891/0889-8391.1.4.264a · Cited by 3,998
(2008) · Cited by 3,790
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Items 101–163 of 163
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Fullana, M. A., & Simpson, H. B. (2016) · Current Treatment Options in Psychiatry · doi:10.1007/s40501-016-0087-4 · Cited by 8
Tibi, L., van Oppen, P., van Balkom, A. J. L. M., Eikelenboom, M., Visser, H. A. D., & Anholt, G. E. (2023) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/00048674231173342 · Cited by 8
Symptom trajectories of early responders and remitters among youth with OCD
Rech, M., Weinzimmer, S. A., GELLER, D. A., Mcguire, J. F., Schneider, S. C., Patyk, K. C., Nadai, A. S. D., Cepeda, S. C., Small, B. J., Murphy, T. K., et al. (2020) · Journal of Obsessive-Compulsive and Related Disorders · doi:10.1016/j.jocrd.2020.100580 · Cited by 7
Grützmann, R., Klawohn, J., Elsner, B., Reuter, B., Kaufmann, C., Riesel, A., Bey, K., Heinzel, S., & Kathmann, N. (2022) · NeuroImage Clinical · doi:10.1016/j.nicl.2022.103216 · Cited by 5
Li, M. L. Y., Lee, S. S. M., & Sündermann, O. (2024) · JMIR mhealth and uhealth · doi:10.2196/63316 · Cited by 5
Ghasemi, F., Shalbaf, A., & Esteki, A. (2025) · IEEE Access · doi:10.1109/access.2025.3558845 · Cited by 7
van de Mortel, L. A., Bruin, W. B., Alonso, P., Bertolín, S., Feusner, J. D., Guo, J. Y., Hagen, K., Hansen, B. K. A., Thorsen, A. L., Martínez‐Zalacaín, I., et al. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.119729 · Cited by 6
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Rickelt, J., Viechtbauer, W., Marcelis, M. C., van den Heuvel, O. A., van Oppen, P., Eikelenboom, M., & Schruers, K. R. J. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.10.078 · Cited by 6
Moreau, A. L., Hansen, I. S., & Bogdan, R. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1432253 · Cited by 6
Zaccari, V., Gragnani, A., Pellegrini, V., Caiazzo, T., D’Arienzo, M. C., Magno, A., Femia, G., & Mancini, F. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.755744 · Cited by 6
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Giridharan, N., Smárason, O., Provenza, N. R., Banks, G. P., Shofty, B., Goodman, W. K., Sheth, S. A., & Storch, E. A. (2023) · Advances in Psychiatry and Behavioral Health · doi:10.1016/j.ypsc.2023.03.010 · Cited by 5
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Wheaton, M. G., Hagen, K., Björgvinsson, Þ., Kvale, G., & Hansen, B. K. A. (2024) · Journal of Obsessive-Compulsive and Related Disorders · doi:10.1016/j.jocrd.2024.100871 · Cited by 3
Bjurner, P., Isacsson, N. H., Abdesslem, F. B., Boman, M., Forsell, E., & Kaldo, V. (2025) · Internet Interventions · doi:10.1016/j.invent.2025.100816 · Cited by 3
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Bernaldo-de-Quirós, M., Labrador, F., García-Fernández, G., Fernández-Arias, I., Estupiñá, F., & Labrador-Méndez, M. (2015) · Psicothema · doi:10.7334/psicothema2014.264 · Cited by 3
Garey, L., Kauffman, B. Y., Manning, K. F., Taha, S. A., Schmidt, N. B., Neighbors, C., & Zvolensky, M. J. (2019) · Journal of addiction medicine · doi:10.1097/adm.0000000000000445 · Cited by 3
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Roy, S., Arturi, L., Parlatini, V., & Cortese, S. (2024) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2024.0066 · Cited by 2
Wheaton, M. G. (2025) · CBT: science into practice · doi:10.1007/978-3-031-91439-3_14 · Cited by 2
Kruisbrink, M., Zijlstra, G. A. R., Crutzen, R., Dorresteijn, T. A. C., Winkens, B., & Kempen, G. I. J. M. (2023) · Journal of Applied Gerontology · doi:10.1177/07334648231165904 · Cited by 1
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Öst, L., Andersson, E., Liberman, L. C., Fladvad, A., Havnen, A., Riise, E. N., Wahlund, T., & Wergeland, G. J. (2026) · Cognitive Behaviour Therapy · doi:10.1080/16506073.2026.2696809 · Cited by 1
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Astaneh, A. N., Sadighi, G., Alibeigi, N., Abdollahzadeh, P., & Abdollahzadeh, B. (2022) · Medical Journal of the Islamic Republic of Iran · doi:10.47176/mjiri.36.13 · Cited by 1
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Kasemsap, K. (2021) · IGI Global eBooks · doi:10.4018/978-1-7998-8544-3.ch026 · Cited by 1
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Nowak, S., Osen, B., & Kröger, C. B. (2019) · PPmP - Psychotherapie · Psychosomatik · Medizinische Psychologie · doi:10.1055/a-0975-9628 · Cited by 1
Murphy, Y. E., Luke, A. K., & Flessner, C. A. (2019) · Cambridge University Press eBooks · doi:10.1017/9781108235655.023 · Cited by 2
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Kruisbrink, M. (2022) · Research Publications (Maastricht University) · doi:10.26481/dis.20220510mk · Cited by 1
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Grassi, M. (2022) · doi:10.26481/dis.20220919mg · Cited by 1
Jones, H. M. (2014) · UWM Digital Commons (University of Wisconsin–Milwaukee)
Prediktion av utfall utifrån terapeutskattningar tidigt i internetförmedlad KBT mot insomni
von Plauen, R. (2015) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
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Kasemsap, K. (2017) · Advances in psychology, mental health, and behavioral studies (APMHBS) book series · doi:10.4018/978-1-5225-3241-5.ch001
Linardon, J. (2017) · Research Bank (Australian Catholic University) · doi:10.26199/5b8dcc74f80b7
Mathieu, S. L. (2020) · Griffith Research Online · doi:10.25904/1912/2664
Le linee guida per il trattamento psicologico del disturbo ossessivo-compulsivo: una panoramica
Mancini, F. (2021) · QUADERNI DI PSICOTERAPIA COGNITIVA · doi:10.3280/qpc47-2020oa11210
Rickelt, J. (2022) · Research Publications (Maastricht University) · doi:10.26481/dis.20221215jr
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Abramowitz, J. S., Taylor, S. J., & McKay, D. (2023) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780190068752.013.19
Wheaton, M. G., Rosenfield, B., Rosenfield, D., Marsh, R., Foa, E. B., & Simpson, H. B. (2023) · Journal of Obsessive-Compulsive and Related Disorders · doi:10.1016/j.jocrd.2023.100850
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Andrade, J. B. D. S., Silva, A. R. S. E., & Fontenelle, L. F. (2023) · Springer eBooks · doi:10.1007/978-3-031-43356-6_16
Insights in Public Mental Health: 2022
Wulf Rössler, A. (2024) · Frontiers research topics · doi:10.3389/978-2-8325-4490-7
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Voderholzer, U., Rubart, A., Kathmann, N., Staniloiu, A., Kordon, A., & Zurowski, B. (2024) · Springer eBooks · doi:10.1007/978-3-662-67878-7_5
Sonneveldt, I. J., Wolf, N., van Balkom, A. J. L. M., van Enckevort, L., van Genugten, C., Kampman, M., van Oppen, P., van Straten, A., Toffolo, M. B. J., & Visser, H. A. D. (2025) · Journal of Obsessive-Compulsive and Related Disorders · doi:10.1016/j.jocrd.2025.100936
Vousoura, E., Gergov, V., Tulbure, B. T., Camilleri, N., Saliba, A., Garcia-Lopez, L., Podina, I. R., Prevendar, T., Löffler‐Stastka, H., Chiarenza, G. A., et al. (2021) · Figshare · doi:10.6084/m9.figshare.16544055
Nielsen, S. K. K., Stuart, A. C., Pedersen, M. Ø., Winding, C., Rosenberg, N., Hageman, I., Jørgensen, M. B., & Vangkilde, S. (2026) · Psychotherapy Research · doi:10.1080/10503307.2026.2671186
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Browning, M. E., Nota, J. A., & Kirk, N. P. V. (2026) · Journal of Behavior Therapy and Experimental Psychiatry · doi:10.1016/j.jbtep.2026.102141
Metadata
- Authors
- Knopp, J., Knowles, S., Bee, P., Lovell, K., & Bower, P.
- Affiliations
- Manchester Academic Health Science Centre (GB)
- University of Manchester (GB)
- Corresponding author
- Knopp, Jasmin
- Venue
- Clinical Psychology Review
- Publisher
- Elsevier BV
- Published
- 2013-12
- Volume
- 33
- Issue
- 8
- Pages
- 1067-1081
- ISSN
- 0272-7358 (ISSN-L)
- OpenAlex
- W2161829398
- Cited by
- 164
- References
- 95
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 14 · 2023: 16 · 2022: 15 · 2021: 15 · 2020: 13 · 2019: 15 · 2018: 11 · 2017: 14 · 2016: 13 · 2015: 18 · 2014: 4
- FWCI
- 1.71
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Clinical Psychology Review (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion, other-oa)
- Funders
- National Institute for Health and Care Research (SPCR-040)
- NIHR School for Primary Care Research
- Topics
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
- Keywords
- obsessive-compulsive disorder, psychotherapy, treatment response, predictors of treatment outcome, moderators of treatment outcome, treatment moderators, hoarding, anxiety, symptom severity, unemployment, marital status, reporting quality
- MeSH terms
- Humans, Obsessive-Compulsive Disorder, Risk Factors, Severity of Illness Index, Treatment Outcome, Marital Status
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