Clinical predictors of response to cognitive-behavioral therapy for obsessive–compulsive disorder

Keeley, Mary L.; Storch, Eric A.; Merlo, Lisa J.; Geffken, Gary R.

doi:10.1016/j.cpr.2007.04.003

Cited by 261Obsessive-Compulsive Spectrum DisordersAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesPsychoanalysis and Psychopathology Research

Clinical predictors of response to cognitive-behavioral therapy for obsessive–compulsive disorder

Keeley, Mary L., Storch, Eric A., Merlo, Lisa J., Geffken, Gary R.·2008·Clinical Psychology Review

DOI 10.1016/j.cpr.2007.04.003

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Abstract

This paper reviews predictors of treatment response in open and controlled trials of cognitive-behavioral therapy for obsessive-compulsive disorder (OCD). We focus on demographic characteristics, aspects of OCD symptoms, comorbidity, family factors, cognitive influences, and treatment-specific characteristics as predictor variables. Although inconsistent findings characterize much of the literature, several relatively consistent and salient predictors have emerged, including symptom severity, symptom subtype, severe depression, the presence of comorbid personality disorders, family dysfunction, and the therapeutic alliance. Implications of findings and recommendations for future research are discussed.

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In CBT for anxiety disorders, demographic variables (age, sex and socioeconomic status) are usually not significant predictors of treatment outcome and treatment adherence.
“In CBT for anxiety disorders, demographic variables (i.e., age, sex and socioeconomic status) are usually not significant predictors of treatment outcome and treatment adherence [42,43,44,45,46,47].”
From A Multisite Non-Inferiority Randomized Controlled Trial of the Efficacy of Cognitive-Behavior Therapy for Generalized Anxiety Disorder Delivered by Videoconference (2022) · cites this paper as [44]
One review concluded that poorer performance on tests of attention, speed, and executive function were generally associated with poorer response to CBT for obsessive-compulsive disorder.
“One review concluded that poorer performance on tests of attention, speed, and executive function were generally associated with poorer response to CBT for obsessive-compulsive disorder.”
From Neuropsychological Functioning and Treatment Outcomes in Acceptance and Commitment Therapy for Chronic Pain. (2018) · cites this paper as [24]
The relationship between NP functioning and treatment responses to psychosocial therapy has been investigated in other conditions.
“However, this relationship has been investigated in other conditions.”
From Neuropsychological Functioning and Treatment Outcomes in Acceptance and Commitment Therapy for Chronic Pain. (2018) · cites this paper as [24]

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Authors: Keeley, M. L., Storch, E. A., Merlo, L. J., & Geffken, G. R.
Affiliations: University of Florida Health (US)
University of Florida (US)
Corresponding author: Storch, Eric A.
ORCID: Storch, Eric A.
Merlo, Lisa J.
Venue: Clinical Psychology Review
Publisher: Elsevier BV
Published: 2008-01
Volume: 28
Issue: 1
Pages: 118-130
ISSN: 0272-7358 (ISSN-L)
DOI: 10.1016/j.cpr.2007.04.003
OpenAlex: W2038125410
Cited by: 261
References: 108
Citations by year: 2026: 7 · 2025: 13 · 2024: 16 · 2023: 12 · 2022: 20 · 2021: 10 · 2020: 16 · 2019: 13 · 2018: 16 · 2017: 11 · 2016: 21 · 2015: 23 · 2014: 14 · 2013: 16 · 2012: 18
FWCI: 8.33
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Clinical Psychology Review (publishedVersion)
PubMed (publishedVersion)
Topics: Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
Keywords: obsessive-compulsive disorder, cognitive behavioral therapy, treatment response, predictors of treatment outcome, symptom severity, comorbid depression, personality disorders, family dysfunction, therapeutic relationship, comorbidities
MeSH terms: Adult, Clinical Trials as Topic, Female, Humans, Male, Obsessive-Compulsive Disorder, Personality Disorders, Prognosis, Severity of Illness Index, Comorbidity, Cognitive Behavioral Therapy, Treatment Outcome

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Clinical predictors of response to cognitive-behavioral therapy for obsessive–compulsive disorder

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