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Cited by 558

The DOI matches its Crossref record; 319 of the 319 references it cites were found in a registry or an index.

European evidence-based Consensus on the management of ulcerative colitis: Current management

Open access
Travis, S.P.L., Stange, E.F., Lémann, M., Øresland, T., Bemelman, W.A., Chowers, Y., Colombel, J.F., D'Haens, G., Ghosh, S., Marteau, P., Kruis, W., Mortensen, N.J.McC., Penninckx, F., Gassull, M.·2008·Journal of Crohn's and Colitis
DOI 10.1016/j.crohns.2007.11.002
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Abstract

The general principles for treating active ulcerative colitis are to consider the activity, distribution (proctitis, left-sided, extensive,1 and pattern of disease (relapse frequency, course of disease, response to previous medications, side-effect profile of medication, extra-intestinal manifestation), before treatment decisions are made in conjunction with the patient. The principal scoring systems used for clinical trials are covered in Section 5.1.2 and have been comprehensively reviewed.2 Some additional points are clinically relevant. In clinical practice it matters most to distinguish severe ulcerative colitis necessitating hospital admission from those with mild or moderate disease who can generally be treated as outpatients. The simplest, best validated and most widely used index for identifying acute severe UC remains that of Truelove & Wi_tts 3: any patient who has a bloody stool frequency ≥ 6/day and a tachycardia (> 90 bpm), or temperature > 37.8 °C, or anaemia (haemoglobin < 10.5 g/dL), or an elevated ESR (> 30 mm/h) has severe ulcerative colitis (Table 1.3). This index has been used in 20/32 studies of intensive intravenous treatment for severe UC.4 Only one additional criterion in addition to the bloody stool frequency ≥ 6/day is needed to define a severe attack.5 While these criteria have the major limitation of being unresponsive and cannot track the course of disease, they do distinguish the severe from the moderate or mild and have value in everyday practice because they are easy to use, which no other index achieves. It should be standard practice to confirm active colitis by sigmoidoscopy or proctoscopy before starting treatment. Rectal mucosal biopsy helps exclude unexpected causes of symptoms similar to active disease (such as cytomegalovirus, amoebic, or other infection, rectal mucosal prolapse, Crohn's disease, or even irritable bowel syndrome and haemorrhoidal bleeding).

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Metadata

Authors
Travis, S. P. L., Stange, E. F., Lémann, M., Øresland, T., Bemelman, W. A., Chowers, Y., Colombel, J. F., D'Haens, G., Ghosh, S., Marteau, P., Kruis, W., Mortensen, N. J. M., Penninckx, F., & Gassull, M.
Venue
Journal of Crohn's and Colitis
Publisher
Oxford University Press (OUP)
Published
2008-03
Volume
2
Issue
1
Pages
24-62
ISSN
1873-9946 (ISSN-L)
DOI
10.1016/j.crohns.2007.11.002
OpenAlex
W2101604689
Cited by
558
References
319
FWCI
31.11
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: European evidence-based Consensus on the management of ulcerative colitis: Current management. https://app.cochat.ai/papers/10.1016/j.crohns.2007.11.002
The paper
Travis, S. P. L., Stange, E. F., Lémann, M., Øresland, T., Bemelman, W. A., Chowers, Y., Colombel, J. F., D'Haens, G., Ghosh, S., Marteau, P., Kruis, W., Mortensen, N. J. M., Penninckx, F., & Gassull, M. (2008). European evidence-based Consensus on the management of ulcerative colitis: Current management. Journal of Crohn's and Colitis. https://doi.org/10.1016/j.crohns.2007.11.002

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.