The natural history of corticosteroid therapy for inflammatory bowel disease: A population-based study
Open accessAbstract
Background & aims The aim of this study was to determine the 1-year outcome after the first course of corticosteroids in an inception cohort of patients with inflammatory bowel disease.Methods All patients in Olmsted County, Minnesota, diagnosed with Crohn's disease (n = 173) or ulcerative colitis (n = 185) from 1970 to 1993 who were treated with systemic corticosteroids were identified (4 denied research authorization). Immediate outcome (30 days) and 1-year outcome after the first course of corticosteroids were determined.Results Seventy-four (43%) patients with Crohn's disease and 63 (34%) with ulcerative colitis were treated with corticosteroids. Immediate outcomes for Crohn's disease were complete remission in 43 (58%), partial remission in 19 (26%), and no response in 12 (16%). Immediate outcomes for ulcerative colitis were complete remission in 34 (54%), partial remission in 19 (30%), and no response in 10 (16%). One-year outcomes for Crohn's disease were prolonged response in 24 (32%), corticosteroid dependence in 21 (28%), operation in 28 (38%), and lost to follow-up in 1 (1%). One-year outcomes for ulcerative colitis were prolonged response in 31 (49%), corticosteroid dependence in 14 (22%), and operation in 18 (29%).Conclusions Most patients with Crohn's disease and ulcerative colitis initially respond to corticosteroids. At 1 year, 32% of patients with Crohn's disease and 48% with ulcerative colitis are corticosteroid free without operation.
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GCs are currently one of the most widely used first-line agents in the treatment of IBD.
“GCs are currently one of the most widely used first-line agents in the treatment of IBD.16”
From Using Corticosteroids to Reshape the Gut Microbiome: Implications for Inflammatory Bowel Diseases (2015) · cites this paper as [16]
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- Authors
- Faubion, W. A., Loftus, E. V., Harmsen, W. S., Zinsmeister, A. R., & Sandborn, W. J.
- Affiliations
- Mayo Clinic (US)
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2001-08
- Volume
- 121
- Issue
- 2
- Pages
- 255-260
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W2167152940
- Cited by
- 1,144
- References
- 27
- Citations by year
- 2026: 11 · 2025: 23 · 2024: 21 · 2023: 33 · 2022: 29 · 2021: 28 · 2020: 37 · 2019: 53 · 2018: 35 · 2017: 59 · 2016: 49 · 2015: 53 · 2014: 64 · 2013: 57 · 2012: 66
- FWCI
- 13.22
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR030582, AR30582)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
- Keywords
- corticosteroid therapy, inflammatory bowel disease, Crohn's disease, ulcerative colitis, remission, steroid dependence, treatment outcomes, Olmsted County, Minnesota
- MeSH terms
- Adolescent, Adrenal Cortex Hormones, Adult, Aged, Aged, 80 and over, Clinical Protocols, Colitis, Ulcerative, Crohn Disease, Female, Follow-Up Studies, Humans, Male, Middle Aged, Retrospective Studies, Cohort Studies, Logistic Models
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