The DOI matches its Crossref record; 62 of the 65 references it cites were found in a registry or an index.
Do Inflammatory Bowel Disease patients with anxiety and depressive symptoms receive the care they need?
Open accessAbstract
Background and aims: Inflammatory Bowel Disease (IBD) patients with anxiety and/or depressive symptoms may not receive the care they need. Provision of care requires insight into the factors affecting these psychiatric symptoms. The study was designed to examine the extent to which: (1) IBD patients with anxiety and/or depressive symptoms receive mental treatment and (2) clinical and socio-demographic variables are associated with these symptoms. Methods: 231 adult IBD patients (79% response rate), attending a tertiary care center, completed standardized measures on anxiety and depressive symptoms (HADS), quality of life (SF-12) and mental health care use (TIC-P). Diagnosis and disease activity were determined by the gastroenterologist. Results: 43% had high levels of anxiety and/or depressive symptoms, indicative of a psychiatric disorder (HADS ≥ 8), of whom 18% received psychological treatment and 21% used psychotropic medication. In multivariate analysis, high disease activity was associated with anxiety (OR = 2.72 | p < 0.03) and depression (OR = 3.36 | p < 0.01), while Crohn's disease was associated with anxiety (OR = 2.60 | p < 0.03). Conclusions: Despite high levels of anxiety and depressive symptoms and poor quality of life, psychiatric complaints in IBD patients were undertreated. Screening for and treatment of psychiatric symptoms should become an integral part of IBD medical care. Highlights: ► 18 % of IBD patients with high levels of anxiety and depression receive mental help. ► Higher levels of depression and anxiety are associated with having active disease. ► Screening should become an integral part of IBD medical care. ► Psychological interventions for anxiety and depression in IBD patients are needed.
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“Twenty-one of the 28 studies measured anxiety, with only three of them concluding there were statistically significant differences between IBD subtypes, all of which indicated higher anxiety for those with CD (21, 29, 41).”
From Controversies Revisited: A Systematic Review of the Comorbidity of Depression and Anxiety with Inflammatory Bowel Diseases (2016) · cites this paper as [29]
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Cites
1 retracted
Inflammatory Bowel Disease as a Risk Factor for Colorectal Cancer
Lukáš, M. (2010) · Digestive Diseases · doi:10.1159/000320276 · Cited by 99
RetractedTabachnick, B. G., & Fidell, L. S. (1983) · Cited by 79,882
The Hospital Anxiety and Depression Scale
Zigmond, A. S., & Snaith, R. P. (1983) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1983.tb09716.x · Cited by 47,139
Kessler, R. C. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950010008002 · Cited by 12,370
The validity of the Hospital Anxiety and Depression Scale
Bjelland, I., Dahl, A. A., Haug, T. T., & Neckelmann, D. (2002) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(01)00296-3 · Cited by 9,779
An Ultra-Brief Screening Scale for Anxiety and Depression: The PHQ–4
Kroenke, K., Spitzer, R. L., Williams, J. B. W., & Löwe, B. (2009) · Psychosomatics · doi:10.1016/s0033-3182(09)70864-3 · Cited by 4,261
A SIMPLE INDEX OF CROHN'S-DISEASE ACTIVITY
Harvey, R. F., & Bradshaw, J. M. (1980) · The Lancet · doi:10.1016/s0140-6736(80)92767-1 · Cited by 2,974
Cross-Validation of Item Selection and Scoring for the SF-12 Health Survey in Nine Countries
Gandek, B., Ware, J. E., Aaronson, N. K., Apolone, G., Bjorner, J. B., Brazier, J. E., Bullinger, M., Kaasa, S., Leplege, A., Prieto, L., et al. (1998) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(98)00109-7 · Cited by 2,907
Cortisone in Ulcerative Colitis
Truelove, S. C., & Witts, L. J. (1955) · BMJ · doi:10.1136/bmj.2.4947.1041 · Cited by 2,793
SPINHOVEN, P., ORMEL, J., SLOEKERS, P. P. A., KEMPEN, G. I. J. M., SPECKENS, A. E. M., & HEMERT, A. M. V. (1997) · Psychological Medicine · doi:10.1017/s0033291796004382 · Cited by 2,158
Flagged first, then by citations
3 of the 65 references couldn’t be matched to a known paper.
Research works printed but not linked: 3
- Graff, 2010, It's not just about the gut: managing depression and anxiety in inflammatory bowel disease, Pract Gastroenterol, 14, 11
- Iglesias, 2009, Psychological impact of Crohn's disease on patients in remission: anxiety and depression risks, Rev Esp Enferm Dig, 101, 249
- Díaz Sibaja, 2007, Protocolized cognitive behavioural group therapy for inflammatory bowel disease, Rev Esp Enferm Dig, 99, 593
Cited by
Sorted by citations
Items 101–130 of 130
Editorial: suicide and IBD—a call to action
Banerjee, T., & Gearry, R. B. (2019) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.15299 · Cited by 4
Monocyte/macrophage mediates the impact of depression on Crohn’s disease
Zhang, X., Wang, P., Yang, Y., Gao, X., Tang, Y., Luo, Y., Deng, X., Yu, Y., Zhang, L., & Zhang, Y. (2023) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365521.2023.2245938 · Cited by 3
Perceived Need for Mental Health Care in a Cohort of Persons With Inflammatory Bowel Disease
Bernstein, C. N., Dolovich, C., Prichodko, M., Fisk, J. D., Graff, L. A., Patten, S. B., Bolton, J. M., Hitchon, C. A., Marrie, R. A., & for the CIHR Team in Defining the Burden and Managing the Effects of Immune-mediated Inflammatory Disease (2023) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000001892 · Cited by 3
El rol del psicogastroenterólogo en los equipos de salud
Tovar, M. G. (2020) · Psicología y Salud · doi:10.25009/pys.v31i1.2682 · Cited by 3
Inflammatory bowel disease (IBD) activity and depression
Mattar, M. C., Duong, N. K., Hussain, N., Kallus, S. J., & Som, A. (2018) · Gastroenterology & Hepatology Open Access · doi:10.15406/ghoa.2018.09.00316 · Cited by 3
MacDonald, M., Heisler, C., Willett, N., Rohatinsky, N., Farina, S., Stewart, M., Vallis, M., Shepherd, T., Currie, B., Robar, J., et al. (2025) · Journal of the Canadian Association of Gastroenterology · doi:10.1093/jcag/gwaf024 · Cited by 2
Àcciari, A. S. (2023) · Seven Editora eBooks · doi:10.56238/cienciasaudeestuepesv1-079 · Cited by 2
Àcciari, A. S., Leão, F. C., Coy, C. S. R., Leal, R. F., Dias, C. C., Saldanha, V., & Ayrizono, M. D. L. S. (2015) · Journal of Coloproctology · doi:10.1016/j.jcol.2015.06.001 · Cited by 2
Inflammatory bowel disease: an overview on assessment
Bettany, J., & Gardiner, A. B. (2013) · Nursing and Residential Care · doi:10.12968/nrec.2013.15.9.607 · Cited by 2
Radford, S. J. (2019) · Gastrointestinal Nursing · doi:10.12968/gasn.2019.17.4.30 · Cited by 2
Patricia, F., Lesley A, G., Gia Ly, J., Maia, K., Shelby, A., Dale, D., Teaghan, P., & Charles N, B. (2022) · Journal of Depression and Anxiety Disorders · doi:10.36959/362/481 · Cited by 1
Emotional dysfunction and inflammatory bowel disease
Li, S., & Wu, Q. (2019) · World Chinese Journal of Digestology · doi:10.11569/wcjd.v27.i12.727 · Cited by 1
Gastrointestinal Disorders: Inflammatory Bowel Disease and Irritable Bowel Syndrome
Graff, L. A., & Lackner, J. M. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-818697-8.00118-7 · Cited by 1
Zhang, H., Han, M., He, Y., Wang, L., Hou, W., Guo, J., & Zhao, Q. (2025) · Psychology Health & Medicine · doi:10.1080/13548506.2025.2564311 · Cited by 1
Low Dose Pregabalin Improves Gastrointestinal Symptoms of Crohn’s Disease
D’Onofrio, A. M., Vincenzo, F. D., Ferrajoli, G. F., Scaldaferri, F., & Camardese, G. (2024) · Case Reports in Gastrointestinal Medicine · doi:10.1155/2024/3744500 · Cited by 1
How Can We Improve to Keep Our Patients Out of the Hospital?
Schmidt, T., & Feagins, L. A. (2018) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izy335 · Cited by 1
EVALUATING PREDICTIVE FACTORS FOR DISEASE ACTIVITY AMONG PATIENTS WITH INFLAMMATORY BOWEL DISEASE
Gîlcă-Blanariu, G.-E., Ștefănescu, G., Afrăsânie, V.-A., Gologan, E., Mitrică, D., Timofte, O., Bălan, G. G., OLTEANU, A. V., & Ciocoiu, M. (2020) · The Medical-Surgical Journal · Cited by 1
Chauhan, U. (2019) · Springer eBooks · doi:10.1007/978-3-319-75022-4_48 · Cited by 1
Psychiatric morbidity in inflammatory bowel disease: Time to screen all the patients
Desai, D. (2018) · Indian Journal of Gastroenterology · doi:10.1007/s12664-018-0891-4 · Cited by 1
McCusker, A. (2015) · Enlighten: Theses (The University of Glasgow)
Bettany, J., Consultant, N., & Gardiner, A. B. (2013)
Medication management in pediatric chronic illness: Should patient anxiety be considered?
Hoogendoorn, C. J. (2016) · CUNY Academic Works (City University of New York)
Placebo-Controlled Trials in the Management of Crohn’s Disease: An Umbrella Review of Meta-Analyses
Silva, R., de Azevedo, J. N., Machado, J. P., & Rodrigues, J. M. (2025) · Medical Sciences · doi:10.3390/medsci13010012
Chauhan, U., Stretton, J., & Watson, M. (2025) · Springer eBooks · doi:10.1007/978-3-031-87503-8_54
IBD-specific Cognitive Behavioral Therapy: Sustainability of effect after three years
Evertsz, F. B., Goes, F. L. S., Stokkers, P. C. F., Sanderman, R., Verdam, M. G. E., Sprangers, M. A. G., & Bockting, C. (2025) · Clinical Psychology in Europe · doi:10.32872/cpe.14717
Self-citationAdditional file 1 of Inflammatory bowel disease patients’ perspectives of non-medical needs
Norouzkhani, N., Faramarzi, M., Bahari, A., Shirvani, J. S., Eslami, S., & Tabesh, H. (2024) · Figshare · doi:10.6084/m9.figshare.25599871
Experiences and perceptions of IBD-related psychological distress in persons living with IBD
Willett, N., Heisler, C., Rohatinsky, N., Farina, S., Stewart, M., Shepherd, T., Currie, B., Phalen-Kelly, K., Robar, J., Huard, T., et al. (2026) · Journal of the Canadian Association of Gastroenterology · doi:10.1093/jcag/gwag009
Advances in research on comorbidities in inflammatory bowel disease
Zhou, S., & yang, Y. (2026) · World Chinese Journal of Digestology · doi:10.11569/wcjd.v34.i5.385
Avest, M. M. T., Nissen, L. H. C., Bosman, S. J. E., Dijkman, I., Speckens, A. E. M., & Huijbers, M. J. (2026) · Mindfulness · doi:10.1007/s12671-026-02948-x
(2017) · Europe PMC (PubMed Central) · Cited by 86
Metadata
- Authors
- Bennebroek Evertsz', F., Thijssens, N. A. M., Stokkers, P. C. F., Grootenhuis, M. A., Bockting, C. L. H., Nieuwkerk, P. T., & Sprangers, M. A. G.
- Affiliations
- Amsterdam UMC Location University of Amsterdam (NL)
- Sint Lucas Andreas Hospital (NL)
- University of Groningen (NL)
- Venue
- Journal of Crohn's and Colitis
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-02
- Volume
- 6
- Issue
- 1
- Pages
- 68-76
- ISSN
- 1873-9946 (ISSN-L)
- OpenAlex
- W2125913162
- Cited by
- 131
- References
- 65
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 8 · 2023: 7 · 2022: 9 · 2021: 13 · 2020: 16 · 2019: 9 · 2018: 15 · 2017: 6 · 2016: 11 · 2015: 11 · 2014: 5 · 2013: 7 · 2012: 5
- FWCI
- 3.39
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- other-oa
- Locations
- Journal of Crohn s and Colitis (publishedVersion)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- inflammatory bowel disease, anxiety
- MeSH terms
- Adolescent, Adult, Aged, Anxiety, Depression, Female, Humans, Male, Middle Aged, Quality of Life, Surveys and Questionnaires, Socioeconomic Factors, Inflammatory Bowel Diseases, Multivariate Analysis, Young Adult
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