Prevalence of anxiety and depression in patients with inflammatory bowel disease
Open accessAbstract
Background . Inflammatory bowel disease (IBD) patients are not routinely screened for depression and anxiety despite knowledge of an increased prevalence in people with chronic disease and negative effects on quality of life. Methods. Prevalence of anxiety and depression was assessed in IBD outpatients through retrospective chart review. The presence of anxiety and/or depression was determined using the Patient Health Questionnaire-9 and Generalized Anxiety Disorder-7 self-report questionnaires or by diagnosis through psychiatric interview. Patient demographics, disease characteristics, and medication information were also collected. Multivariable analysis was used to determine associations between patient factors and depression and anxiety. Results. 327 patient charts were reviewed. Rates of depression and anxiety were found to be 25.8% and 21.2%, with 30.3% of patients suffering from depression and/or anxiety. Disease activity was found to be significantly associated with depression and/or anxiety ( p = 0.01 ). Females were more likely to have anxiety ( p = 0.01 ). Conclusion. A significant proportion of IBD patients suffer from depression and/or anxiety. The rates of these mental illnesses would justify screening and referral for psychiatric treatment in clinics treating this population. Patients with active disease are particularly at risk for anxiety and depression.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In a 2011 study, authors did not find a significant difference in anxiety and depression levels, and in the frequency of probable mental disorder among patients with Crohn's disease and ulcerative colitis.
“У дослідженні 2011 р. автори не виявили суттєвої різниці за рівнем тривоги та депресії, а також за частотою ймовірного психічного розладу серед пацієнтів із ХК та ВК [55].”
From PSYCHO-EMOTIONAL STATUS IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE (2024) · cites this paper as [55]
The Discussion (§4.1; page unavailable) says the authors found no difference in anxiety and depression prevalence between ulcerative colitis and Crohn’s disease patients, consistent with the 2011 study they cite. It does not report that the 2011 study found no difference in the frequency of probable mental disorder, and the finding presented as the authors’ own is from this 2017 paper, not a 2011 study. (LLM, conf=0.85)
Experimental — accuracy not yet measuredIBD are an important risk factor for mood and anxiety disorders, and these psychiatric conditions increase the risk of exacerbation of IBD.
“In line, IBD are important risk factor for mood and anxiety disorders (111), and these psychiatric conditions increase the risk of exacerbation of IBD (112).”
From Vagus Nerve as Modulator of the Brain–Gut Axis in Psychiatric and Inflammatory Disorders (2018) · cites this paper as [111]
Individuals affected with autoimmune disorders are more likely to display comorbid depressive symptomatology.
“Accordingly, it has been well documented that individual affected with autoimmune disorders (e.g., rheumatoid arthritis, psoriasis, diabetes mellitus, chronic inflammatory bowel disease, and autoimmune thyroiditis) are more likely to display comorbid depressive symptomatology [17,18,19,20,21,22,23].”
From C-Reactive protein as a biomarker for major depressive disorder? (2022) · cites this paper as [23]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The PHQ-9: Validity of a brief depression severity measure
Kroenke, K., Spitzer, R. L., & Williams, J. B. W. (2001) · Journal of General Internal Medicine · doi:10.1046/j.1525-1497.2001.016009606.x · Cited by 44,910 · see citing works
A Brief Measure for Assessing Generalized Anxiety Disorder: The GAD-7
Spitzer, R. L., Kroenke, K., Williams, J. B. W., & Löwe, B. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.10.1092 · Cited by 31,765 · see citing works
DiMatteo, M. R., Lepper, H. S., & Croghan, T. W. (2000) · Archives of Internal Medicine · doi:10.1001/archinte.160.14.2101 · Cited by 4,177 · see citing works
McLean, C. P., Asnaani, A., Litz, B. T., & Hofmann, S. G. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.03.006 · Cited by 2,519 · see citing works
Epidemiology and treatment of depression in patients with chronic medical illness
J. Katon, W. (2011) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2011.13.1/wkaton · Cited by 820 · see citing works
Clarke, D. M., & Currie, K. C. (2009) · Medical Journal of Australia · doi:10.5694/j.1326-5377.2009.tb02471.x · Cited by 661 · see citing works
Langhorst, J., Elsenbruch, S., Koelzer, J., Rueffer, A., Michalsen, A., & Dobos, G. (2007) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2007.01556.x · Cited by 588 · see citing works
Depression and anxiety in inflammatory bowel disease: A review of comorbidity and management
Graff, L. A., Walker, J. R., & Bernstein, C. N. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20873 · Cited by 586 · see citing works
Non-response and related factors in a nation-wide health survey
Korkeila, K., Suominen, S., Ahvenainen, J., Ojanlatva, A., Rautava, P. T., Helenius, H. Y. M., & Koskenvuo, M. (2001) · European Journal of Epidemiology · doi:10.1023/a:1020016922473 · Cited by 512 · see citing works
Defining Disease Severity in Inflammatory Bowel Diseases: Current and Future Directions
Peyrin‐Biroulet, L., Panés, J., Sandborn, W. J., Vermeire, S., Danese, S., Feagan, B. G., Colombel, J., Hanauer, S. B., & Rycroft, B. (2015) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2015.06.001 · Cited by 455 · see citing works
Walker, J. R., Ediger, J. P., Graff, L. A., Greenfeld, J. M., Clara, I., Lix, L., Rawsthorne, P., Miller, N., Rogala, L., McPhail, C. M., et al. (2008) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2008.01980.x · Cited by 437 · see citing works
Guthrie, E., Jackson, J., Shaffer, J., Thompson, D., Tomenson, B., & Creed, F. (2002) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.05842.x · Cited by 306 · see citing works
Fuller-Thomson, E., & Sulman, J. (2006) · Inflammatory Bowel Diseases · doi:10.1097/00054725-200608000-00005 · Cited by 292 · see citing works
Addolorato, G., Capristo, E., Stefanini, G. F., & Gasbarrini, A. (1997) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529709011218 · Cited by 243 · see citing works
Long-term medical conditions and major depression in a Canadian population study at waves 1 and 2
Patten, S. B. (2001) · Journal of Affective Disorders · doi:10.1016/s0165-0327(00)00186-5 · Cited by 238 · see citing works
Goodhand, J. R., Wahed, M., Mawdsley, J. E., Farmer, A. D., Aziz, Q., & Rampton, D. S. (2012) · Inflammatory Bowel Diseases · doi:10.1002/ibd.22916 · Cited by 234 · see citing works
Risk factors of anxiety and depression in inflammatory bowel disease
Nahon, S., Lahmek, P., Durance, C., Olympie, A., Lesgourgues, B., Colombel, J., & Gendre, J. (2012) · Inflammatory Bowel Diseases · doi:10.1002/ibd.22888 · Cited by 201 · see citing works
Psychiatric illness in patients with inflammatory bowel disease.
Andrews, H., Barczak, P., & Allan, R. N. (1987) · Gut · doi:10.1136/gut.28.12.1600 · Cited by 180 · see citing works
Anxiety and depression in patients with inflammatory bowel disease
Häuser, W., Janke, K.-H., Klump, B., & Hinz, A. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21346 · Cited by 163 · see citing works
Janzon, L., Hanson, B. S., Isacsson, S., Lindell, S. ‐., & Steen, B. (1986) · Journal of Epidemiology & Community Health · doi:10.1136/jech.40.2.174 · Cited by 119 · see citing works
The Influence of Depression on Quality of Life in Patients with Inflammatory Bowel Disease
Zhang, H., Hewett, J., Hemming, J., Grant, T., Zhao, H., Abraham, C., Oikonomou, I. K., Kanakia, M., Cho, J. H., & Proctor, D. D. (2013) · Inflammatory Bowel Diseases · doi:10.1097/mib.0b013e318281f395 · Cited by 117 · see citing works
Psychiatric Predictors of Noncompliance in Inflammatory Bowel Disease
Nigro, G., Angelini, G., Grosso, S. B., Caula, G., & Sategna-Guidetti, C. (2001) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-200101000-00015 · Cited by 114 · see citing works
Limsrivilai, J., Stidham, R. W., Govani, S. M., Waljee, A. K., Huang, W., & Higgins, P. (2016) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2016.09.012 · Cited by 102 · see citing works
Robust Association Between Inflammatory Bowel Disease and Generalized Anxiety Disorder
Fuller‐Thomson, E., Lateef, R., & Sulman, J. (2015) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000518 · Cited by 77 · see citing works
Review article: how to control and improve adherence to therapy in inflammatory bowel disease
López-Sanromán, A., & Bermejo, F. (2006) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2006.03060.x · Cited by 57 · see citing works
Nagy, F. T., Molnár, T., Farkas, K., et al. (2012) · Journal of Crohn s and Colitis · doi:10.1016/s1873-9946(12)60455-3 · Cited by 2 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [14]Pearson C. Janz T. Ali J. Health at a glance mental and substance use disorders in Canada Stat. Canada 2013 no. 82 1 8
Cited by
Sorted by citations
Vagus Nerve as Modulator of the Brain–Gut Axis in Psychiatric and Inflammatory Disorders
Breit, S., Kupferberg, A., Rogler, G., & Hasler, G. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00044 · Cited by 1,189 · see citing works
Barberio, B., Zamani, M., Black, C. J., Savarino, E. V., & Ford, A. C. (2021) · The Lancet Gastroenterology & Hepatology · doi:10.1016/s2468-1253(21)00014-5 · Cited by 758 · see citing works
Luo, Y., Zeng, B., Zeng, L., Du, X., Li, B., Huo, R., Liu, L., Wang, H., Dong, M., Pan, J., et al. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0240-5 · Cited by 245 · see citing works
Ge, L., Liu, S., Li, S., Yang, J., Hu, G., Xu, C., & Song, W. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1016578 · Cited by 187 · see citing works
C-Reactive protein as a biomarker for major depressive disorder?
Orsolini, L., Pompili, S., Tempia Valenta, S., Salvi, V., & Volpe, U. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031616 · Cited by 171 · see citing works
Neuroinflammation as an etiological trigger for depression comorbid with inflammatory bowel disease
Craig, C. F., Filippone, R. T., Stavely, R., Bornstein, J. C., Apostolopoulos, V., & Nurgali, K. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02354-1 · Cited by 124 · see citing works
van den Brink, G., Stapersma, L., Vlug, L. E., Rizopolous, D., Bodelier, A. G., van Wering, H., Hurkmans, P. C. W. M., Stuyt, R. J. L., Hendriks, D. M., van der Burg, J. A. T., et al. (2018) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.14832 · Cited by 61 · see citing works
Thavamani, A., Umapathi, K. K., Khatana, J., & Gulati, R. (2019) · Pediatric Gastroenterology, Hepatology & Nutrition · doi:10.5223/pghn.2019.22.6.527 · Cited by 54 · see citing works
Anxiety but not depression predicts poor outcomes in inflammatory bowel disease
Narula, N., Pinto-Sanchez, M. I., Calo, N. C., Ford, A. C., Bercik, P., Reinisch, W., & Moayyedi, P. (2019) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izy385 · Cited by 52 · see citing works
The effect of psychotherapy on quality of life in IBD Patients: A systematic review
Paulides, E., Boukema, I., van der Woude, C. J., & de Boer, N. K. H. (2021) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izaa144 · Cited by 47 · see citing works
Determinants of Sleep Quality in Inflammatory Bowel Diseases
Sochal, M., Małecka-Panas, E., Gabryelska, A., Talar-Wojnarowska, R., Szmyd, B., Krzywdzińska, M., & Białasiewicz, P. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9092921 · Cited by 43 · see citing works
Depression and health care use in patients with inflammatory bowel disease
Wong, J. J., Sceats, L., Dehghan, M., Wren, A. A., Sellers, Z. M., Limketkai, B. N., Bensen, R., Kin, C., & Park, K. T. (2019) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjy145 · Cited by 44 · see citing works
The evolution of IBD perceived engagement and care needs across the life-cycle: a scoping review
Volpato, E., Bosio, C., Previtali, E., Leone, S., Armuzzi, A., Pagnini, F., & Graffigna, G. (2021) · BMC Gastroenterology · doi:10.1186/s12876-021-01850-1 · Cited by 34 · see citing works
Sceats, L. A., Dehghan, M. S., Rumer, K. K., Trickey, A., Morris, A. M., & Kin, C. (2020) · Colorectal Disease · doi:10.1111/codi.14905 · Cited by 33 · see citing works
Wang, J., Nakamura, T. I., Tuskey, A. G., & Behm, B. W. (2019) · Intestinal Research · doi:10.5217/ir.2019.00050 · Cited by 31 · see citing works
“IBD patients with psychiatric illness have been shown to have higher rates of GI symptoms and worse clinical outcomes in other studies.(33,34) A lack of a relationship between psychiatric medication and negative clinical outcomes may suggest that psychiatric illness was adequately managed in this patient cohort, so th…”
ResultSelf-esteem in patients with inflammatory bowel disease
Opheim, R., Moum, B., Grimstad, B. T., Jahnsen, J., Prytz Berset, I., Hovde, Ø., Huppertz-Hauss, G., Bernklev, T., & Jelsness-Jørgensen, L.-P. (2020) · Quality of Life Research · doi:10.1007/s11136-020-02467-9 · Cited by 27 · see citing works
Jain, A., Marrie, R. A., Shafer, L. A., Graff, L. A., Patten, S. B., El-Gabalawy, R., Sareen, J., Bolton, J. M., Fisk, J. D., & Bernstein, C. N. (2020) · Crohn's & Colitis 360 · doi:10.1093/crocol/otz053 · Cited by 16 · see citing works
PSYCHO-EMOTIONAL STATUS IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE
Romanukha, V., Hryniv, O., Hvozdetska, H., Baryla, N., & Hrushetska, A. (2024) · Eastern Ukrainian Medical Journal · doi:10.21272/eumj.2024;12(2):202-211 · Cited by 1 · see citing works
- Authors
- Byrne, G., Rosenfeld, G., Leung, Y., Qian, H., Raudzus, J., Nunez, C., & Bressler, B.
- Affiliations
- University of British Columbia (CA)
- Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
- Corresponding author
- Bressler, Brian
- Venue
- Canadian Journal of Gastroenterology and Hepatology
- Publisher
- Wiley
- Published
- 2017
- Volume
- 2017
- Pages
- 1-6
- ISSN
- 2291-2789 (ISSN-L)
- 2291-2797
- PMC
- PMC5664260
- OpenAlex
- W2765715355
- Cited by
- 234
- References
- 26
- Citations by year
- 2026: 17 · 2025: 19 · 2024: 22 · 2023: 29 · 2022: 40 · 2021: 39 · 2020: 35 · 2019: 21 · 2018: 12
- FWCI
- 12.31
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Canadian Journal of Gastroenterology and Hepatology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- inflammatory bowel disease, depression, anxiety, prevalence, psychiatric comorbidity, disease activity, sex differences, screening, quality of life, outpatients
- MeSH terms
- Adult, Anxiety, Depression, Female, Humans, Male, Middle Aged, Quality of Life, Surveys and Questionnaires, Retrospective Studies, Risk Factors, Sex Factors, Inflammatory Bowel Diseases, Prevalence, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
