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Cited by 240Ultrasound and Hyperthermia ApplicationsCancer Cells and MetastasisNonmelanoma Skin Cancer Studies

The DOI matches its Crossref record; 146 of the 152 references it cites were found in a registry or an index.

Mechanisms of cryoablation: Clinical consequences on malignant tumors

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Baust, J.G., Gage, A.A., Bjerklund Johansen, T.E., Baust, J.M.·2014·Cryobiology
DOI 10.1016/j.cryobiol.2013.11.001PMC PMC3976170
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Abstract

While the destructive actions of a cryoablative freeze cycle are long recognized, more recent evidence has revealed a complex set of molecular responses that provides a path for optimization. The importance of optimization relates to the observation that the cryosurgical treatment of tumors yields success only equivalent to alternative therapies. This is also true of all existing therapies of cancer, which while applied with curative intent; provide only disease suppression for periods ranging from months to years. Recent research has led to an important new understanding of the nature of cancer, which has implications for primary therapies, including cryosurgical treatment. We now recognize that a cancer is a highly organized tissue dependent on other supporting cells for its establishment, growth and invasion. Further, cancer stem cells are now recognized as an origin of disease and prove resistant to many treatment modalities. Growth is dependent on endothelial cells essential to blood vessel formation, fibroblasts production of growth factors, and protective functions of cells of the immune system. This review discusses the biology of cancer, which has profound implications for the diverse therapies of the disease, including cryosurgery. We also describe the cryosurgical treatment of diverse cancers, citing results, types of adjunctive therapy intended to improve clinical outcomes, and comment briefly on other energy-based ablative therapies. With an expanded view of tumor complexity we identify those elements key to effective cryoablation and strategies designed to optimize cancer cell mortality with a consideration of the now recognized hallmarks of cancer.

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Show all 152 references

Research works printed but not linked: 6

  1. Baust, 2014, Analysis of the efficacy scn vs. Argon cryoablation devices in an in vivo-like 3-D tissue engineered prostate and renal model, Cryobiology
  2. Hollister, 1998, Effects of freezing on cell viability and mechanisms of cell death in a human prostate cell line, Mol. Urol., 2, 13
  3. Piro, 2004, Apoptosis, bcl-2 antisense, and cancer therapy, Oncology (Williston Park), 18, 5
  4. Van Buskirk, 2004, Hypothermic storage and cryopreservation – the issues of successful short-term and long term preservation of cells and tissues, BioProcess Int., 2, 42
  5. T. Van der Kwast, Histological effects of prostate therapies, in: Montréal Conference on Focal Therapy for Prostate Cancer, Montreal, Canada, 2012.
  6. A. Villers, Hifu (ablaterm): the French hemi-ablation study, in: Montréal Conference on Focal Therapy for Prostate Cancer, Montreal, Canada, 2012.

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Metadata

Authors
Baust, J. G., Gage, A. A., Bjerklund Johansen, T. E., & Baust, J. M.
Affiliations
  • Binghamton University (US)
  • University at Buffalo, State University of New York (US)
Corresponding author
Baust, J.G.
ORCID
Baust, J.M.
Venue
Cryobiology
Publisher
Elsevier BV
Published
2014-02
Volume
68
Issue
1
Pages
1-11
ISSN
0011-2240 (ISSN-L)
DOI
10.1016/j.cryobiol.2013.11.001
PMC
PMC3976170
OpenAlex
W1985256611
Cited by
239
References
152
Citations by year
2026: 29 · 2025: 20 · 2024: 22 · 2023: 22 · 2022: 23 · 2021: 26 · 2020: 17 · 2019: 17 · 2018: 14 · 2017: 17 · 2016: 12 · 2015: 11 · 2014: 4
FWCI
0.90
Type
journal article
Language
en
Open access
Licence
Locations
  • Cryobiology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institutes of Health
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
  • Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
  • Health Sciences › Medicine › Dermatology › Nonmelanoma Skin Cancer Studies
Keywords
cryoablation, cryosurgery, tumor biology, tumor microenvironment, cancer stem cells, tumor angiogenesis, antitumor immunity, adjunctive therapy, cancer hallmarks
MeSH terms
Combined Modality Therapy, Cryosurgery, Humans, Male, Neovascularization, Pathologic, Prostate, Prostatic Neoplasms, Neoplastic Stem Cells, Apoptosis, Tumor Microenvironment

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