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Functional gastrointestinal disorders in children: Effectivity, safety, and tolerability of the herbal preparation STW-5 (Iberogast®) in general practice
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In the citing paper
“A prospective observational study evaluating STW-5 therapy (10–20 drops three times daily) in 418 IBS pediatric patients (age 3–14 years) observed an improvement of GI symptoms with a decrease from 19.1 ± 8.9 to 4.8 ± 4.6 of the GI symptom score and a good tolerability and only 0.7% patients reporting adverse events [75].”
From Natural Remedies for Irritable Bowel Syndrome: A Comprehensive Review of Herbal-Based Therapies (2025) · cites this paper as [75]
In the citing paper
“A prospective observational study assessing STW 5 (10–20 drops three times daily for one week) in 418 pediatric IBS patients demonstrated improvement in gastrointestinal symptoms score (GIS) (p < 0.0001) and good tolerability (only 0.7% of children reported adverse events) [44].”
From Plant-Derived Treatments for IBS: Clinical Outcomes, Mechanistic Insights, and Their Position in International Guidelines (2026) · cites this paper as [44]
In the citing paper
“Iberogast (STW-5 and STW-5 II) has also demonstrated clinical improvements across multiple trials”
From Plant-Derived Treatments for IBS: Clinical Outcomes, Mechanistic Insights, and Their Position in International Guidelines (2026) · cites this paper as [44]
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Research works printed but not linked: 26
- Saps, 2018, Prevalence of functional gastrointestinal disorders in children and adolescents: comparison between Rome III and Rome IV criteria, J Pediatr, 199, 212, 10.1016/j.jpeds.2018.03.037 · DOI
- Park, 2015, Inpatient burden of childhood functional GI disorders in the USA: an analysis of national trends in the USA from 1997 to 2009, Neurogastroenterol Motil, 27, 684, 10.1111/nmo.12542 · DOI
- Mahon, 2017, The costs of functional gastrointestinal disorders and related signs and symptoms in infants: a systematic literature review and cost calculation for England, BMJ Open, 7, 10.1136/bmjopen-2016-015594 · DOI
- Liebman, 1978, Recurrent abdominal pain in children: a retrospective survey of 119 patients, Clin Pediatr, 17, 149, 10.1177/000992287801700208 · DOI
- Ammoury, 2009, Functional gastrointestinal disorders: past and present, World J Pediatr, 5, 103, 10.1007/s12519-009-0021-6 · DOI
- Drossman, 2006, The functional gastrointestinal disorders and the Rome III process, Gastroenterology, 130, 1377, 10.1053/j.gastro.2006.03.008 · DOI · Paper page
- Chogle, 2009, Environmental factors of abdominal pain, Pediatr Ann, 38, 398, 10.3928/00904481-20090622-10 · DOI
- Rasquin, 2006, Childhood functional gastrointestinal disorders: child/adolescent, Gastroenterology, 130, 1527, 10.1053/j.gastro.2005.08.063 · DOI
- Madisch, 2001, Ein Phytotherapeutikum und seine modifizierte Rezeptur bei funktioneller Dyspepsie, Z Gastroenterol, 39, 1, 10.1055/s-2001-16142 · DOI
- Melzer, 2004, Meta-analysis: phytotherapy of functional dyspepsia with the herbal drug preparation STW 5 (Iberogast), Aliment Pharm Ther, 20, 1279, 10.1111/j.1365-2036.2004.02275.x · DOI
- Malfertheiner, 2017, STW 5 (Iberogast) therapy in gastrointestinal functional disorders, Dig Dis, 35, S25, 10.1159/000485410 · DOI · Paper page
- von Arnim, 2007, STW 5, a phytopharmacon for patients with functional dyspepsia: results of a multicentre, placebo-controlled double-blind study, Am J Gastroenterol, 102, 1268, 10.1111/j.1572-0241.2006.01183.x · DOI
- Buchert, 1994, Wirksamkeit und Verträglichkeit von Iberogast bei Patienten mit gesicherter Non Ulcus Dyspepsie, Z Phytother, 15, 45
- Rösch, 2002, A randomised clinical trial comparing the efficacy of herbal preparation STW-5 with the prokinetic drug cisapride in patients with dysmotility type of functional dyspepsia, Z Gastroenterol, 40, 401, 10.1055/s-2002-32130 · DOI
- Madisch, 2004, Treatment of irritable bowel syndrome with herbal preparations: results of a double-blind, randomised, placebo-controlled, multi-centre trial, Aliment Pharm Ther, 19, 271, 10.1111/j.1365-2036.2004.01859.x · DOI · Paper page
- Sassin, 2000, Efficacy and tolerability of the herbal preparation Iberogast® in the therapy of functional dyspepsia, Phytomedicine, 7, S91
- Klein-Galczinsky, 1999, Anwendungsbeobachtung zur Wirksamkeit und Verträglichkeit von Iberogast® in der Therapie des Colon irritabile, Phytother der Schwelle zum neuen Jahr (Abstr), 125, P25
- Abdel-Aziz, 2017, Evaluating the multitarget effects of combinations through multistep clustering of pharmacological data: the example of the commercial preparation Iberogast, Planta Med, 2017, 1130
- Allescher, 2007, STW 5/Iberogast: multi-Target-Wirkung bei funktioneller Dyspepsie und Reizdarmsyndrom, Wien Med Woche, 157, 301, 10.1007/s10354-007-0429-3 · DOI
- Adam, 2005, Validation of the gastrointestinal symptom score for the assessment of symptoms in patients with functional dyspepsia, Aliment Pharm Ther, 22, 357, 10.1111/j.1365-2036.2005.02572.x · DOI
- Holtmann, 2004, Clinical presentation and personality factors are predictors of the response to treatment in patients with functional dyspepsia: a randomised, double-blind placebo-controlled crossover study, Dig Dis Sci, 49, 672, 10.1023/B:DDAS.0000026317.00071.75 · DOI
- Raedsch, 2018, Early onset of efficacy in patients with functional and motility-related gastrointestinal disorders: a non-interventional study with Iberogast®, Wien Med Woche, 168, 89, 10.1007/s10354-017-0578-y · DOI
- Schemann, 2006, Region-specific effects of STW 5 (Iberogast) and its components in gastric fundus, corpus, and antrum, Phytomedicine, 13, S90, 10.1016/j.phymed.2006.03.020 · DOI
- Pilichiewicz, 2007, Effects of Iberogast on proximal gastric volume, antropyloroduodenal motility, and gastric emptying in healthy men, Am J Gastroenterol, 102, 1276, 10.1111/j.1572-0241.2007.01142.x · DOI
- Schemann M. Iberogast® – Focus regionenspezifische Motilität. Iberogast® Symposium. Bad Wörishofen, Germany; 2010.
- Krueger, 2009, The multi-herbal drug STW 5 (Iberogast) has prosecretory action in the human intestine, Neurogastroenterol Motil, 21, 1203, 10.1111/j.1365-2982.2008.01242.x · DOI
Cited by
Natural Remedies for Irritable Bowel Syndrome: A Comprehensive Review of Herbal-Based Therapies
Abalo, R., Gallego-Barceló, P., & Gabbia, D. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26199345 · Cited by 5
Pastras, P., Aggeletopoulou, I., Bali, M., & Triantos, C. (2026) · Nutrients · doi:10.3390/nu18020183 · Cited by 1
Metadata
- Authors
- Michael, R., Bettina, V., & Eckehard, L.
- Venue
- Complementary Therapies in Medicine
- Publisher
- Elsevier BV
- Published
- 2022-12
- Volume
- 71
- Pages
- 102873
- ISSN
- 0965-2299
- Cited by
- 15
- References
- 0
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- creativecommons.org/licenses/by-nc-nd/4.0/ (vor)
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.