Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 172

The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

Treatment of irritable bowel syndrome with herbal preparations: Results of a double-blind, randomized, placebo-controlled, multi-centre trial

Madisch, A., Holtmann, G., Plein, K., Hotz, J.·2004·Alimentary Pharmacology & Therapeutics
DOI 10.1111/j.1365-2036.2004.01859.x
Open this paper in CoChat — free account

Abstract

Summary: Background : Herbal medications have been used in many countries for the treatment of patients with irritable bowel syndrome. Controlled data supporting the efficacy of these treatments in patients with irritable bowel syndrome are lacking. Aim : To assess the efficacy and safety of a commercially available herbal preparation (STW 5) (nine plant extracts), the research herbal preparation STW 5‐II (six plant extracts) and the bitter candytuft mono‐extract in patients with irritable bowel syndrome. Methods : Two hundred and eight patients with irritable bowel syndrome were recruited after standardized diagnostic work‐up into a double‐blind, placebo‐controlled, multi‐centre trial and were randomly assigned to receive one of four treatments: commercially available herbal preparation STW 5 ( n = 51), research herbal preparation STW 5‐II ( n = 52), bitter candytuft mono‐extract ( n = 53) or placebo ( n = 52). The main outcome variables were the changes in total abdominal pain and irritable bowel syndrome symptom scores. Results : Two hundred and three patients completed the trial. STW 5 and STW 5‐II were significantly better than placebo in reducing the total abdominal pain score (intention‐to‐treat: STW 5, P = 0.0009; STW 5‐II, P = 0.0005) and the irritable bowel syndrome symptom score (intention‐to‐treat: STW 5, P = 0.001; STW 5‐II, P = 0.0003) at 4 weeks. There were no statistically significant differences between the bitter candytuft mono‐extract group and the placebo group ( P = 0.1473, P = 0.1207). Conclusions : The commercially available herbal preparation STW 5 and its research preparation STW 5‐II are both effective in alleviating irritable bowel syndrome symptoms.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1111/j.1365-2036.2004.01859.x

Cites

6 of 6 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 6 references

Research works printed but not linked: 32

  1. 10.1053/gast.1997.v112.agast972120 · DOI · Paper page
  2. 10.1016/0016-5085(92)90320-X · DOI
  3. 10.1136/bmj.304.6819.87 · DOI
  4. 10.1046/j.1365-2036.1997.84256000.x · DOI · Paper page
  5. 10.2165/00003495-199244020-00004 · DOI
  6. 10.1159/000201272 · DOI
  7. ICH Biostatistics., 1998, ICH Biostatistics Guideline. ICH Harmonized Tripartite Guideline. Note for Guidance on Statistical Principles for Clinical Trials. ICH Topic E9, Step 4, Consensus Guideline.
  8. 10.1080/01621459.1984.10478093 · DOI · Paper page
  9. 10.1177/009286159102500311 · DOI
  10. 10.1017/S0266462300007728 · DOI
  11. 10.17660/ActaHortic.1993.332.29 · DOI
  12. Simmen U, 2003, Relevance of the herbal combination of STW 5 for its binding affinity to the muscarinic M3 receptor, Naunyn-Schmiedeberg's Arch Pharmacol, 367, R22
  13. 10.1016/S0140-6736(01)07103-3 · DOI
  14. 10.1097/00004836-200201000-00006 · DOI
  15. 10.1136/gut.48.2.272 · DOI
  16. 10.1016/0016-5085(88)90319-8 · DOI
  17. 10.1001/jama.280.18.1585 · DOI · Paper page
  18. Buchert D, 1994, Wirkung einer fixen Kombination bei gesicherter Non‐Ulcus‐Dyspepsie, Z Phytother, 15, 24
  19. Holtmann G, 1999, Treatment of functional dyspepsia with a herbal preparation — results of a double‐blind, randomized, placebo‐controlled, multicenter trial, Gastroenterology, 116, AG0275
  20. 10.1055/s-2001-16142 · DOI
  21. Holtmann G, 1997, Functional dyspepsia and irritable bowel syndrome: is there a common pathophysiological basis?, Am J Gastroenterol, 92, 954
  22. Khayyal MT, 2001, Antiulcerogenic effect of some gastrointestinally acting plant extracts and their combination, Arzneim-Forsch/Drug Res, 15, 545
  23. 10.1111/j.1365-2036.1994.tb00322.x · DOI
  24. Dew MJ, 1995, Peppermint oil for the irritable bowel syndrome: a multicentre trial, Br J Clin Pract, 38, 394.
  25. 10.1136/bmj.2.6194.835 · DOI
  26. Duthie HL, 1981, The effect of peppermint oil on colonic motility in man, Br J Surg, 68, 820
  27. 10.1007/BF02936952 · DOI · Paper page
  28. 10.1016/0016-5085(91)90459-X · DOI
  29. 10.1111/j.1572-0241.1998.00343.x · DOI · Paper page
  30. 10.1016/S0016-5085(99)70410-5 · DOI
  31. 10.1136/gut.36.1.146 · DOI
  32. 10.1046/j.1365-2036.1999.00678.x · DOI

Cited by

See all 172

Metadata

Authors
Madisch, A., Holtmann, G., Plein, K., & Hotz, J.
Venue
Alimentary Pharmacology & Therapeutics
Publisher
Wiley
Published
2004-01-20
Volume
19
Issue
3
Pages
271-279
ISSN
  • 0269-2813
  • 1365-2036
DOI
10.1111/j.1365-2036.2004.01859.x
Cited by
172
References
6
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Treatment of irritable bowel syndrome with herbal preparations: Results of a double-blind, randomized, placebo-controlled, multi-centre trial. https://app.cochat.ai/papers/10.1111/j.1365-2036.2004.01859.x
The paper
Madisch, A., Holtmann, G., Plein, K., & Hotz, J. (2004). Treatment of irritable bowel syndrome with herbal preparations: Results of a double-blind, randomized, placebo-controlled, multi-centre trial. Alimentary Pharmacology & Therapeutics. https://doi.org/10.1111/j.1365-2036.2004.01859.x

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.