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Cited by 157Cancer survivorship and carePhysical Activity and HealthCardiovascular and exercise physiology

Effects of exercise in patients treated with stem cell transplantation for a hematologic malignancy: a systematic review and meta-analysis

Persoon, Saskia, Kersten, Marie José, van der Weiden, Karen, Buffart, Laurien M., Nollet, Frans, Brug, Johannes, Chinapaw, Mai J.M.·2013·Cancer Treatment Reviews
DOI 10.1016/j.ctrv.2013.01.001
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Abstract

We performed a systematic review and meta-analysis evaluating the effectiveness of exercise interventions compared with usual care on physical fitness, fatigue and health-related quality of life in patients with hematologic malignancies treated with stem cell transplantation. Electronic databases were searched up to June 2012. We included randomized controlled trials comparing exercise with usual care, in which at least 75% of the patients had a hematologic malignancy. Standard mean differences were calculated and pooled to generate summary effect sizes (ES) and 95% confidence intervals (CI). The Cochrane Collaboration Risk of Bias Tool was used to assess the methodological quality of the studies. Eight studies met our inclusion criteria. Exercise had a statistically significant moderately favourable effect on cardiorespiratory fitness (ES=0.53, 95% CI=0.13-0.94), lower extremity muscle strength (ES=0.56, 95% CI=0.18-0.94) and fatigue (ES=0.53, 95% CI=0.27-0.79). Significant small positive effects were found for upper extremity muscle strength, global quality of life, and physical, emotional and cognitive functioning. In conclusion, exercise seems to have beneficial effects in patients treated with stem cell transplantation. However, all studies had at least some risk of bias, and for cardiorespiratory fitness and lower extremity muscle strength substantial heterogeneity in effect sizes were observed. Further high quality research is needed to determine the optimal exercise intervention and clinical implications.

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  • Moderate intensity aerobic training three times per week for 12 weeks or twice weekly combined aerobic plus resistance training for 6-12 weeks significantly reduces anxiety in cancer survivors during and after treatment.

    “A dose of moderate intensity aerobic training three times per week for 12 weeks or twice weekly combined aerobic plus resistance training for 6–12 weeks can significantly reduce anxiety in cancer survivors during and after treatment(13–17).”

    From Exercise Guidelines for Cancer Survivors: Consensus Statement from International Multidisciplinary Roundtable (2019) · cites this paper as [13]

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Authors
Persoon, S., Kersten, M. J., van der Weiden, K., Buffart, L. M., Nollet, F., Brug, J., & Chinapaw, M. J. M.
Affiliations
  • Amsterdam UMC Location University of Amsterdam (NL)
  • Amsterdam Public Health (NL)
Corresponding author
  • Persoon, Saskia
  • Kersten, Marie José
  • Buffart, Laurien M.
  • Nollet, Frans
  • Brug, Johannes
  • Chinapaw, Mai J.M.
ORCID
Venue
Cancer Treatment Reviews
Publisher
Elsevier BV
Published
2013-10
Volume
39
Issue
6
Pages
682-690
ISSN
0305-7372 (ISSN-L)
DOI
10.1016/j.ctrv.2013.01.001
OpenAlex
W2112031532
Cited by
157
References
46
Citations by year
2026: 6 · 2025: 13 · 2024: 12 · 2023: 6 · 2022: 11 · 2021: 15 · 2020: 15 · 2019: 9 · 2018: 20 · 2017: 15 · 2016: 15 · 2015: 12 · 2014: 8
FWCI
1.23
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Cancer Treatment Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • Pure Amsterdam UMC (submittedVersion)
Funders
Alpe d’HuZes/KWF Fund
Topics
  • Health Sciences › Medicine › Oncology › Cancer survivorship and care
  • Health Sciences › Medicine › Physiology › Physical Activity and Health
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Keywords
exercise intervention, hematologic malignancies, stem cell transplantation, physical fitness, cardiorespiratory fitness, muscle strength, fatigue, health-related quality of life, post-transplant rehabilitation
MeSH terms
Exercise Therapy, Fatigue, Humans, Quality of Life, Exercise, Outcome Assessment, Health Care, Hematopoietic Stem Cell Transplantation, Hematologic Neoplasms

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