LKB1 Is the Upstream Kinase in the AMP-Activated Protein Kinase Cascade

Role of AMP-Activated Protein Kinase in Mechanism of Metformin Action

Zhou, G., Myers, R., Li, Y., Chen, Y., Shen, X., Fenyk-Melody, J., Wu, M., Ventre, J., Doebber, T., Fujii, N., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13505 · Cited by 5,652

Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase

Minokoshi, Y., Kim, Y.-B., Peroni, O. D., Fryer, L. G. D., Müller, C., Carling, D., & Kahn, B. B. (2002) · Nature · doi:10.1038/415339a · Cited by 2,053

A serine/threonine kinase gene defective in Peutz–Jeghers syndrome

Hemminki, A., Markie, D., Tomlinson, I. P. M., Avizienyte, E., Roth, S., Loukola, A., Bignell, G. R., Warren, W., Aminoff, M., Höglund, P., et al. (1998) · Nature · doi:10.1038/34432 · Cited by 1,680

THE AMP-ACTIVATED/SNF1 PROTEIN KINASE SUBFAMILY: Metabolic Sensors of the Eukaryotic Cell?

Hardie, D. G., Carling, D., & Carlson, M. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.821 · Cited by 1,440

Characterization of the AMP-activated Protein Kinase Kinase from Rat Liver and Identification of Threonine 172 as the Major Site at Which It Phosphorylates AMP-activated Protein Kinase

Hawley, S. A., Davison, M., Woods, A., Davies, S. P., Beri, R. K., Carling, D., & Hardie, D. G. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.44.27879 · Cited by 1,264

Peutz-Jeghers syndrome is caused by mutations in a novel serine threoninekinase

Jenne, D. E., Reomann, H., Nezu, J., Friedel, W., Loff, S., Jeschke, R., Müller, O., Back, W. E., & Zimmer, M. (1998) · Nature Genetics · doi:10.1038/ng0198-38 · Cited by 1,201

The Anti-diabetic Drugs Rosiglitazone and Metformin Stimulate AMP-activated Protein Kinase through Distinct Signaling Pathways

Fryer, L. G. D., Patel, A. P., & Carling, D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202489200 · Cited by 1,035

AMP-activated protein kinase, a metabolic master switch: possible roles in Type 2 diabetes

Winder, W. W., & Hardie, D. G. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.277.1.e1 · Cited by 1,000

Characterization of AMP-activated protein kinase γ-subunit isoforms and their role in AMP binding

CHEUNG, P. C. F., SALT, I. P., DAVIES, S. P., HARDIE, D. G., & CARLING, D. (2000) · Biochemical Journal · doi:10.1042/bj3460659 · Cited by 637

Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases

Hong, S. P., Leiper, F. C., Woods, A., Carling, D., & Carlson, M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1533136100 · Cited by 617

Nutrient Signaling and Lysosome Positioning Crosstalk Through a Multifunctional Protein, Folliculin

Garrido, N. D. M., & Aylett, C. H. S. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00108 · Cited by 37

Differential requirements for STRAD in LKB1-dependent functions in C. elegans

Narbonne, P., Hyenne, V., Li, S., Labbé, J.-C., & Roy, R. (2010) · Development · doi:10.1242/dev.042044 · Cited by 36

Adiponectin Enhances Intercellular Adhesion Molecule-1 Expression and Promotes Monocyte Adhesion in Human Synovial Fibroblasts

Chen, H., Tsou, H., Chen, J., Shih, J. M.-K., Chen, Y., & Tang, C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092741 · Cited by 36

Insulin-Sensitizers, Polycystic Ovary Syndrome and Gynaecological Cancer Risk

Lauretta, R., Lanzolla, G., Vici, P., Mariani, L., Moretti, C., & Appetecchia, M. (2016) · International Journal of Endocrinology · doi:10.1155/2016/8671762 · Cited by 36

Evaluation of the Neuroprotective Effect of Sirt3 in Experimental Stroke

Verma, R., Ritzel, R. M., Crapser, J. D., Friedler, B. D., & McCullough, L. D. (2018) · Translational Stroke Research · doi:10.1007/s12975-017-0603-x · Cited by 36

Regulation of Carbon and Amino Acid Metabolism: Roles of Sucrose Nonfermenting‐1‐Related Protein Kinase‐1 and General Control Nonderepressible‐2‐Related Protein Kinase

Halford, N. G. (2005) · Advances in botanical research · doi:10.1016/s0065-2296(05)43002-5 · Cited by 36

Glycogen debranching enzyme association with β-subunit regulates AMP-activated protein kinase activity

Sakoda, H., Fujishiro, M., Fujio, J., Shojima, N., Ogihara, T., Kushiyama, A., Fukushima, Y., Anai, M., Ono, H., Kikuchi, M., et al. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00003.2005 · Cited by 36

Activation of SAD Kinase by Ca2+/Calmodulin-Dependent Protein Kinase Kinase

Fujimoto, T., Yurimoto, S., Hatano, N., Nozaki, N., Sueyoshi, N., Kameshita, I., Mizutani, A., Mikoshiba, K., Kobayashi, R., & Tokumitsu, H. (2008) · Biochemistry · doi:10.1021/bi702528r · Cited by 35

Enhanced Ca 2+ entry and Na + /Ca 2+ exchanger activity in dendritic cells from AMP‐activated protein kinase‐deficient mice

Nurbaeva, M. K., Schmid, E., Szteyn, K., Yang, W., Viollet, B., Shumilina, E. V., & Lang, F. J. W. (2012) · The FASEB Journal · doi:10.1096/fj.12-204024 · Cited by 35

Treatment With Treprostinil and Metformin Normalizes Hyperglycemia and Improves Cardiac Function in Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction

Wang, L., Halliday, G., Huot, J. R., Satoh, T., Baust, J., Fisher, A. J., Cook, T. G., HU, J. L., Avolio, T., Goncharov, D. A., et al. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.119.313883 · Cited by 37

Targeting Mitochondrial Metabolism in Prostate Cancer with Triterpenoids

Mamouni, K., Kallifatidis, G., & Lokeshwar, B. L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052466 · Cited by 37

AMPK and Pulmonary Hypertension: Crossroads Between Vasoconstriction and Vascular Remodeling

Zhao, Q., Song, P., & Zou, M. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.691585 · Cited by 37

Fyn-phosphorylated PIKE-A binds and inhibits AMPK signaling, blocking its tumor suppressive activity

Zhang, S., Qi, Q., Chan, C. B., Zhou, W., Chen, J., Luo, H. R., Appin, C., Brat, D. J., & Ye, K.-N. (2015) · Cell Death and Differentiation · doi:10.1038/cdd.2015.66 · Cited by 35

Nanosecond pulsed electric fields activate AMP-activated protein kinase: Implications for calcium-mediated activation of cellular signaling

Morotomi‐Yano, K., Akiyama, H., & Yano, K. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.10.061 · Cited by 35

Dysregulation of mTOR activity through LKB1 inactivation

Zhou, W., Marcus, A. I., & Vertino, P. M. (2013) · 癌症：英文版 · doi:10.5732/cjc.013.10086 · Cited by 38

Genetic Alterations in Sporadic and Hereditary Colorectal Cancer: Implementations for Screening and Follow-Up

Souglakos, J. (2007) · Digestive Diseases · doi:10.1159/000099166 · Cited by 36

cis-9,trans-11-Conjugated Linoleic Acid Activates AMP-Activated Protein Kinase in Attenuation of Insulin Resistance in C2C12 Myotubes

Qin, H., Liu, Y., Lu, N., Li, Y., & Sun, C. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf900534w · Cited by 35

Systems biology of energy homeostasis in yeast

Zhang, J., Vemuri, G. N., & Nielsen, J. (2010) · Current Opinion in Microbiology · doi:10.1016/j.mib.2010.04.004 · Cited by 37

The AMPKyl subunit plays an essential role in erythrocyte membrane elasticity, and its genetic inactivation induces splenomegaly and anemia

Foretz, M., Hébrard, S., Guihard, S., Leclerc, J., Cruzeiro, M. D., Hamard, G., Niedergang, F., Gaudry, M., & Viollet, B. (2010) · The FASEB Journal · doi:10.1096/fj.10-169383 · Cited by 40

Sex-Specific Regulation of AMP-Activated Protein Kinase (AMPK) in the Pacific Oyster Crassostrea gigas1

Guévélou, É., Huvet, A., Galindo‐Sánchez, C. E., Milan, M., Quillien, V., Daniel, J.-Y., Quéré, C., Boudry, P., & Corporeau, C. (2013) · Biology of Reproduction · doi:10.1095/biolreprod.113.109728 · Cited by 35

AMPK in the central nervous system: physiological roles and pathological implications

Segatto, M., Rosso, P., Fioramonti, M., Fracassi, A., Marangoni, M., Taglietti, V., & Siteni, S. (2016) · Research and Reports in Biology · doi:10.2147/rrb.s90858 · Cited by 35

Generation of Autonomous Activity of Ca2+/Calmodulin-Dependent Protein Kinase Kinase β by Autophosphorylation

Tokumitsu, H., Hatano, N., Fujimoto, T., Yurimoto, S., & Kobayashi, R. (2011) · Biochemistry · doi:10.1021/bi201005g · Cited by 35

Acute stimulation of glucose influx upon mitoenergetic dysfunction requires LKB1, AMPK, Sirt2 and mTOR–RAPTOR

Liemburg-Apers, D. C., Wagenaars, J. A. L., Smeitink, J. A. M., Willems, P. H. G. M., & Koopman, W. J. H. (2016) · Journal of Cell Science · doi:10.1242/jcs.194480 · Cited by 35

The Effects of Altitude Training on the AMPK-Related Glucose Transport Pathway in the Red Skeletal Muscle of Both Lean and Obese Zucker Rats

Chen, Y., Lee, S., Ho, L.-T., & Kuo, C. (2011) · High Altitude Medicine & Biology · doi:10.1089/ham.2010.1088 · Cited by 36

Decoding key nodes in the metabolism of cancer cells: sugar & spice and all things nice

Cantley, L., & Shaw, R. (2011) · F1000 Biology Reports · doi:10.3410/b4-2 · Cited by 34

AMPK allostery: A therapeutic target for the management/treatment of diabetic nephropathy

Ayinde, K. S., Olaoba, O. T., Boyenle, I. D., Du, L., Lü, Q., Yin, X., & Adelusi, T. I. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118455 · Cited by 34

A revisit to O2 sensing and transduction in the carotid body chemoreceptors in the context of reactive oxygen species biology

González, C., Agapito, M. T., Rocher, A., Gómez-Niño, Á., Rigual, R. J., Castañeda, J., Conde, S. V., & Obeso, A. (2010) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2010.09.002 · Cited by 34

The hexosamine biosynthesis pathway and O‐Glc NA cylation maintain insulin‐stimulated PI 3K‐ PKB phosphorylation and tumour cell growth after short‐term glucose deprivation

Jones, D. R., Keune, W., Anderson, K. E., Stephens, L., Hawkins, P. T., & Divecha, N. (2014) · FEBS Journal · doi:10.1111/febs.12879 · Cited by 35

The LKB1 complex-AMPK pathway: the tree that hides the forest

Sebbagh, M., Olschwang, S., Santoni, M.-J., & Borg, J. (2011) · Familial Cancer · doi:10.1007/s10689-011-9457-7 · Cited by 38

Targeting the mTOR/4E-BP Pathway in Endometrial Cancer

Korets, S. B., Czok, S., Blank, S. V., Curtin, J. P., & Schneider, R. J. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-1664 · Cited by 34

AMP‐activated protein kinase phosphorylation in brain is dependent on method of killing and tissue preparation

Scharf, M. T., Mackiewicz, M., Naidoo, N. N., O'Callaghan, J. P., & Pack, A. I. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.05182.x · Cited by 34

AMPK

Carling, D. (2004) · Current Biology · doi:10.1016/j.cub.2004.02.048 · Cited by 34

The Mammalian Target of Rapamycin Kinase and Tumor Growth Inhibition

Boulay, A., & Lane, H. A. (2007) · Springer eBooks · doi:10.1007/978-3-540-31209-3_7 · Cited by 34

Mitochondrial Biology and Disease in Dictyostelium

Barth, C., Le, P. T., & Fisher, P. R. (2007) · International review of cytology · doi:10.1016/s0074-7696(07)63005-8 · Cited by 34

The KSHV K1 Protein Modulates AMPK Function to Enhance Cell Survival

Anders, P., Zhang, Z., Bhende, P. M., Giffin, L., & Damania, B. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005985 · Cited by 33

Tumor Necrosis Factor-α Promotes Phosphoinositide 3-Kinase Enhancer A and AMP-Activated Protein Kinase Interaction to Suppress Lipid Oxidation in Skeletal Muscle

Tse, M. C. L., Herlea‐Pana, O., Brobst, D. E., Yang, X., Wood, J., Hu, X., Liu, Z., Lee, C. W., Zaw, A. M., Chow, B., et al. (2017) · Diabetes · doi:10.2337/db16-0270 · Cited by 33

Role of Akt-independent mTORC1 and GSK3β signaling in sublethal NMDA-induced injury and the recovery of neuronal electrophysiology and survival

Swiatkowski, P., Nikolaeva, I., Kumar, G., Zucco, A. J., Akum, B. F., Patel, M. V., D’Arcangelo, G., & Firestein, B. L. (2017) · Scientific Reports · doi:10.1038/s41598-017-01826-w · Cited by 33

Involvement of AMP-activated protein kinase and Death Receptor 5 in TRAIL-Berberine-induced apoptosis of cancer cells

Ke, R., Vishnoi, K., Viswakarma, N., Santha, S., Das, S., Rana, A., & Rana, B. (2018) · Scientific Reports · doi:10.1038/s41598-018-23780-x · Cited by 33

AMPK-Independent LKB1 Activity Is Required for Efficient Epithelial Ovarian Cancer Metastasis

Buensuceso, A. V., Ramos-Valdes, Y., DiMattia, G. E., & Shepherd, T. G. (2019) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-19-0530 · Cited by 35

Upregulation of programmed death ligand 1 by liver kinase B1 and its implication in programmed death 1 blockade therapy in non-small cell lung cancer

Shen, X., Zhao, Y., Liu, G., Zhou, H.-L., Fan, J., Zhang, L., Li, Y., Wang, Y., Liang, J., & Xu, Z. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117923 · Cited by 33

Induction of STK11-dependent cytoprotective autophagy in breast cancer cells upon honokiol treatment

Muniraj, N., Siddharth, S., Shriver, M., Nagalingam, A., Parida, S., Woo, J., Elsey, J., Gabrielson, K. L., Gabrielson, E. W., Arbiser, J. L., et al. (2020) · Cell Death Discovery · doi:10.1038/s41420-020-00315-w · Cited by 33

Synthesis and Biological Evaluation of Novel Bouchardatine Derivatives as Potential Adipogenesis/Lipogenesis Inhibitors for Antiobesity Treatment

Rao, Y., Liu, H., Gao, L., Yu, H., Ou, T., Tan, J., Huang, S., Wang, H., Li, D., Gu, L., et al. (2015) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5b01566 · Cited by 33

Fyn phosphorylates AMPK to inhibit AMPK activity and AMP-dependent activation of autophagy

Yamada, E., Okada, S., Bastie, C. C., Vatish, M., Nakajima, Y., Shibusawa, R., Ozawa, A., Pessin, J. E., & Yamada, M. (2016) · Oncotarget · doi:10.18632/oncotarget.11916 · Cited by 33

Endurance training increases LKB1 and MO25 protein but not AMP-activated protein kinase kinase activity in skeletal muscle

Taylor, E. B., Hurst, D., Greenwood, L. J., Lamb, J. D., Cline, T. D., Sudweeks, S. N., & Winder, W. W. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00179.2004 · Cited by 33

Deciphering the ferroptosis pathways in dorsal root ganglia of Friedreich ataxia models. The role of LKB1/AMPK, KEAP1, and GSK3β in the impairment of the NRF2 response

Sanz‐Alcázar, A., Portillo-Carrasquer, M., Delaspre, F., Pazos-Gil, M., Tamarit, J., Ros, J., & Cabiscol, E. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103339 · Cited by 33

AMPK-sensitive cellular transport

Dërmaku‐Sopjani, M., Abazi, S., Faggio, C., Kolgeci, J., & Sopjani, M. (2014) · The Journal of Biochemistry · doi:10.1093/jb/mvu002 · Cited by 33

Mitochondria-associated endoplasmic reticulum membranes in the heart

Wu, S., & Zou, M. (2018) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2018.12.018 · Cited by 33

Anti-inflammatory Property of AMP-activated Protein Kinase

Noor, H. B., Mou, N. A., Salem, L., Shimul, M. F. A., Biswas, S., Akther, R., Khan, S., Raihan, S., Mohib, M. M., & Sagor, M. A. T. (2019) · Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry · doi:10.2174/1871523018666190830100022 · Cited by 34

Berberine attenuates fructose-induced insulin resistance by stimulating the hepatic LKB1/AMPK/PGC1α pathway in mice

Li, Y., Wang, B., Shen, J.-D., Bai, M., & Xu, E. (2020) · Pharmaceutical Biology · doi:10.1080/13880209.2020.1756349 · Cited by 32

Is metformin a possible treatment for diabetic neuropathy?

Wei, J., Wei, Y., Huang, M., Wang, P., & Jia, S. (2022) · Journal of Diabetes · doi:10.1111/1753-0407.13310 · Cited by 32

Rapid metabolic reprogramming mediated by the AMP-activated protein kinase during the lytic cycle of Toxoplasma gondii

Li, Y., Niu, Z., Yang, J., Yang, X., Chen, Y., Li, Y., Liang, X., Zhang, J., Fan, F., Wu, P., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-36084-0 · Cited by 32

Chemopreventive efficacy of rapamycin on Peutz–Jeghers syndrome in a mouse model

Wei, C., Amos, C. I., Zhang, N., Zhu, J., Wang, X., & Frazier, M. L. (2009) · Cancer Letters · doi:10.1016/j.canlet.2008.11.036 · Cited by 32

AMP‐activated protein kinase underpins hypoxic pulmonary vasoconstriction and carotid body excitation by hypoxia in mammals

Evans, A. M. (2006) · Experimental Physiology · doi:10.1113/expphysiol.2006.033514 · Cited by 33

AICAR Preconditioning Prevents Postischemic Leukocyte Rolling and Adhesion: Role of KATP Channels and Heme Oxygenase

Gaskin, F. S., Kamada, K., Yusof, M., Durante, W., Gross, G. J., & Korthuis, R. J. (2009) · Microcirculation · doi:10.1080/10739680802355897 · Cited by 32

Ciclopirox olamine inhibits mTORC1 signaling by activation of AMPK

Zhou, H., Shang, C., Wang, M., Shen, T., Kong, L., Yu, C., Ye, Z.-N., Luo, Y., Liu, L., Li, Y., et al. (2016) · Biochemical Pharmacology · doi:10.1016/j.bcp.2016.07.005 · Cited by 32

New Candidate Targets of AMP-Activated Protein Kinase in Murine Brain Revealed by a Novel Multidimensional Substrate-Screen for Protein Kinases

Tuerk, R. D., Thali, R. F., Auchli, Y., Rechsteiner, H., Brunisholz, R., Schlattner, U., Wallimann, T., & Neumann, D. (2007) · Journal of Proteome Research · doi:10.1021/pr070160a · Cited by 35

Muscarinic Receptor Activation of AMP-activated Protein Kinase Inhibits Orexigenic Neuropeptide mRNA Expression

Thornton, C., Sardini, A., & Carling, D. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m708987200 · Cited by 32

Portal Venous 5-Aminoimidazole-4-Carboxamide-1-β- d -Ribofuranoside Infusion Overcomes Hyperinsulinemic Suppression of Endogenous Glucose Output

Camacho, R. C., Pencek, R., Lacy, D. B., James, F. D., Donahue, E. P., & Wasserman, D. H. (2005) · Diabetes · doi:10.2337/diabetes.54.2.373 · Cited by 32

Physiological Expression of AMPKγ2 Mutation Causes Wolff-Parkinson-White Syndrome and Induces Kidney Injury in Mice

Yang, X., Mudgett, J. S., About, G. B., Champy, M., Jacobs, H., Monassier, L., Pavlovic, G., Sorg, T., Hérault, Y., Petit‐Demoulière, B., et al. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.738591 · Cited by 31

Omega-3 Polyunsaturated Fatty Acids Prevent Toxoplasma gondii Infection by Inducing Autophagy via AMPK Activation

Choi, J.-W., Lee, J., Lee, J.-H., Park, B., Lee, E. J., Shin, S., Cha, G., Lee, Y., Lim, K., & Yuk, J. (2019) · Nutrients · doi:10.3390/nu11092137 · Cited by 31

Prostate Cancer Energetics and Biosynthesis

Lin, C., Salzillo, T. C., Bader, D. A., Wilkenfeld, S. R., Awad, D., Pulliam, T. L., Dutta, P., Pudakalakatti, S., Titus, M. A., McGuire, S. E., et al. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-32656-2_10 · Cited by 33

PTEN inhibits AMPK to control collective migration

Péglion, F., Capuana, L., Perfettini, I., Boucontet, L., Braithwaite, B., Colucci‐Guyon, E., Quissac, E., Forsberg‐Nilsson, K., Llense, F., & Etienne‐Manneville, S. (2022) · Nature Communications · doi:10.1038/s41467-022-31842-y · Cited by 31

(S)-[6]-Gingerol enhances glucose uptake in L6 myotubes by activation of AMPK in response to [Ca2+]i

Li, Y., Tran, V. H., Koolaji, N., Duke, C. C., & Roufogalis, B. D. (2013) · Journal of Pharmacy & Pharmaceutical Sciences · doi:10.18433/j34g7p · Cited by 31

LKB1 Is an Essential Regulator of Spermatozoa Release during Spermiation in the Mammalian Testis

Denison, F. C., Smith, L. B., Muckett, P. J., O’Hara, L., Carling, D., & Woods, A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028306 · Cited by 34

Deletion of MLIP (Muscle-enriched A-type Lamin-interacting Protein) Leads to Cardiac Hyperactivation of Akt/Mammalian Target of Rapamycin (mTOR) and Impaired Cardiac Adaptation

Cattin, M., Wang, J., Weldrick, J. J., Roeske, C. L., Mak, E., Thorn, S., DaSilva, J. N., Wang, Y., Lusis, A. J., & Burgon, P. G. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.678433 · Cited by 32

5′-AMP-Activated Protein Kinase Regulates Papillary (TPC-1 and BCPAP) Thyroid Cancer Cell Survival, Migration, Invasion, and Epithelial-to-Mesenchymal Transition

Cazarin, J., Coelho, R. G., Hecht, F., Andrade, B. M., & de Carvalho, D. P. (2016) · Thyroid · doi:10.1089/thy.2015.0440 · Cited by 31

Troglitazone acutely activates AMP-activated protein kinase and inhibits insulin secretion from beta cells

Wang, X., Zhou, L., Shao, L., Qian, L., Fu, X., Li, G., Luo, T., Gu, Y., Li, F., Li, J., et al. (2007) · Life Sciences · doi:10.1016/j.lfs.2007.04.034 · Cited by 31

Activation of the AMP-activated protein kinase–p38 MAP kinase pathway mediates apoptosis induced by conjugated linoleic acid in p53-mutant mouse mammary tumor cells

Hsu, Y.-C., Meng, X., Ou, L., & Ip, M. M. (2009) · Cellular Signalling · doi:10.1016/j.cellsig.2009.11.011 · Cited by 30

A plant kinase plays roles in defense response against geminivirus by phosphorylation of a viral pathogenesis protein

Shen, Q., Bao, M., & Zhou, X. (2012) · Plant Signaling & Behavior · doi:10.4161/psb.20646 · Cited by 30

IKK promotes cytokine-induced and cancer-associated AMPK activity and attenuates phenformin-induced cell death in LKB1-deficient cells

Antonia, R. J., & Baldwin, A. S. (2018) · Science Signaling · doi:10.1126/scisignal.aan5850 · Cited by 30

Mitochondrial dysfunction regulates the JAK–STAT pathway via LKB1-mediated AMPK activation ER-stress-independent manner

Kim, D.-Y., Lim, S., Suk, K., & Lee, W. (2019) · Biochemistry and Cell Biology · doi:10.1139/bcb-2019-0088 · Cited by 30

GDF11 replenishment protects against hypoxia-mediated apoptosis in cardiomyocytes by regulating autophagy

Jiao, L., Shao, Y., Yu, Q., Li, M., Wang, Y., Gong, M., Yang, X., Liu, T., Li, Z., Liu, H., et al. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173495 · Cited by 30

LKB1: An emerging therapeutic target for cardiovascular diseases

Molaei, A., Molaei, E., Sadeghnia, H. R., Hayes, A. W., & Karimi, G. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.120844 · Cited by 30

Coordination of the AMPK, Akt, mTOR, and p53 Pathways under Glucose Starvation

Zhou, Y., & Liu, F. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232314945 · Cited by 32

LKB1 regulates TCR‐mediated PLCγ1 activation and thymocyte positive selection

Cao, Y., Li, H., Liu, H., Zhang, M., Hua, Z., Ji, H., & Liu, X. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.116 · Cited by 30

Determinants of oligosaccharide specificity of the carbohydrate-binding modules of AMP-activated protein kinase

Mobbs, J. I., Koay, A. Z., Paolo, A. D., Bieri, M., Petrie, E. J., Gorman, M. A., Doughty, L., Parker, M. W., Stapleton, D., Griffin, M. D. W., et al. (2015) · Biochemical Journal · doi:10.1042/bj20150270 · Cited by 30

Activation of phosphatidylinositol-3 kinase, AMP-activated kinase and Akt substrate-160 kDa by trans-10, cis-12 conjugated linoleic acid mediates skeletal muscle glucose uptake

Mohankumar, S. K., Taylor, C. G., Siemens, L., & Zahradka, P. C. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2012.01.006 · Cited by 30

α-Lipoic acid as a triglyceride-lowering nutraceutical

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