Carling, David

Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

Yamauchi, T., Kamon, J., Minokoshi, Y., Ito, Y., Waki, H., Uchida, S., Yamashita, S., Noda, M., Kita, S., Ueki, K., et al. (2002) · Nature Medicine

Adipokines, Inflammation, and Metabolic DiseasesMetabolism, Diabetes, and Cancer

Cited by 4,238

AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism

Kahn, B. B., Alquier, T., Carling, D., & Hardie, D. G. (2005) · Cell Metabolism

Metabolism, Diabetes, and CancerAdipokines, Inflammation, and Metabolic Diseases

Cited by 2,799

Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase

Minokoshi, Y., Kim, Y.-B., Peroni, O. D., Fryer, L. G. D., Müller, C., Carling, D., & Kahn, B. B. (2002) · Nature

Metabolism, Diabetes, and CancerRegulation of Appetite and Obesity

Cited by 2,053

The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism

Frost, G., Sleeth, M. L., Sahuri-Arisoylu, M., Lizarbe, B., Cerdan, S., Brody, L., Anastasovska, J., Ghourab, S., Hankir, M., Zhang, S., et al. (2014) · Nature Communications

Regulation of Appetite and ObesityGut microbiota and health

Cited by 1,771

LKB1 is the upstream kinase in the AMP-activated protein kinase cascade

Woods, A., Johnstone, S. R., Dickerson, K., Leiper, F. C., Fryer, L. G. D., Neumann, D., Schlattner, U., Wallimann, T., Carlson, M., & Carling, D. (2003) · Current Biology

Metabolism, Diabetes, and CancerPI3K/AKT/mTOR signaling in cancer

Cited by 1,650

The AMP‐Activated Protein Kinase: Fuel Gauge of the Mammalian Cell?

Hardie, D. G., & Carling, D. (1997) · European Journal of Biochemistry

Metabolism, Diabetes, and CancerBiochemical and Molecular Research

Cited by 1,317

Characterization of the AMP-activated Protein Kinase Kinase from Rat Liver and Identification of Threonine 172 as the Major Site at Which It Phosphorylates AMP-activated Protein Kinase

Hawley, S. A., Davison, M., Woods, A., Davies, S. P., Beri, R. K., Carling, D., & Hardie, D. G. (1996) · Journal of Biological Chemistry

Metabolism, Diabetes, and CancerProtein Kinase Regulation and GTPase Signaling

Cited by 1,264

Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

Selman, C., Tullet, J. M. A., Wieser, D., Irvine, E., Lingard, S. J., Choudhury, A. I., Claret, M., Al-Qassab, H., Carmignac, D., Ramadani, F., et al. (2009) · Science

Genetics, Aging, and Longevity in Model OrganismsPI3K/AKT/mTOR signaling in cancer

Cited by 1,120

Structure of mammalian AMPK and its regulation by ADP

Xiao, B., Sanders, M. J., Underwood, E., Heath, R., Mayer, F. V., Carmena, D., Jing, C., Walker, P. A., Eccleston, J. F., Haire, L. F., et al. (2011) · Nature

Metabolism, Diabetes, and CancerBiochemical and Molecular Research

Cited by 926

AMPK signalling in health and disease

Carling, D. (2017) · Current Opinion in Cell Biology

Metabolism, Diabetes, and CancerBiochemical and Molecular Research

Cited by 797

Characterization of AMP-activated protein kinase γ-subunit isoforms and their role in AMP binding

CHEUNG, P. C. F., SALT, I. P., DAVIES, S. P., HARDIE, D. G., & CARLING, D. (2000) · Biochemical Journal

Metabolism, Diabetes, and CancerBiochemical and Molecular Research

Cited by 637

A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis

Carling, D., Zammit, V. A., & Hardie, D. G. (1987) · FEBS Letters

Cancer, Lipids, and MetabolismLipid metabolism and biosynthesis

Cited by 599

Structural basis for AMP binding to mammalian AMP-activated protein kinase

Xiao, B., Heath, R., Saiu, P., Leiper, F. C., Leone, P., Jing, C., Walker, P. A., Haire, L., Eccleston, J. F., Davis, C. T., et al. (2007) · Nature

Metabolism, Diabetes, and CancerBiochemical and Molecular Research

Cited by 591

The AMP-activated protein kinase α2 catalytic subunit controls whole-body insulin sensitivity

Viollet, B., Andreelli, F., Jørgensen, S. B., Perrin, C., Geloen, A., Flamez, D., Mu, J., Lenzner, C., Baud, O., Bennoun, M., et al. (2003) · Journal of Clinical Investigation

Metabolism, Diabetes, and CancerPancreatic function and diabetes

Cited by 499

Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family

Sanders, M. J., Ali, Z. S., Hegarty, B. D., Heath, R., Snowden, M. A., & Carling, D. (2007) · Journal of Biological Chemistry

Metabolism, Diabetes, and CancerBiochemical and Molecular Research

Cited by 347

Identification by amino acid sequencing of three major regulatory phosphorylation sites on rat acetyl-CoA carboxylase

MUNDAY, M. R., CAMPBELL, D. G., CARLING, D., & HARDIE, D. G. (1988) · European Journal of Biochemistry

Metabolism, Diabetes, and CancerCancer, Lipids, and Metabolism

Cited by 308

Mitochondria-derived ROS activate AMP-activated protein kinase (AMPK) indirectly

Hinchy, E. C., Gruszczyk, A. V., Willows, R., Navaratnam, N., Hall, A. R., Bates, G., Bright, T. P., Krieg, T., Carling, D., & Murphy, M. P. (2018) · Journal of Biological Chemistry

Metabolism, Diabetes, and CancerRedox biology and oxidative stress

Cited by 302

The substrate and sequence specificity of the AMP-activated protein kinase. Phosphorylation of glycogen synthase and phosphorylase kinase

Carling, D., & Grahame Hardie, D. (1989) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Metabolism, Diabetes, and CancerProtein Kinase Regulation and GTPase Signaling

Cited by 296

Increased AMP:ATP ratio and AMP-activated protein kinase activity during cellular senescence linked to reduced HuR function

Wang, W., Yang, X., López de Silanes, I., Carling, D., & Gorospe, M. (2003) · Journal of Biological Chemistry

Telomeres, Telomerase, and SenescenceMetabolism, Diabetes, and Cancer

Cited by 243

Identification of a Novel AMP-activated Protein Kinase β Subunit Isoform That Is Highly Expressed in Skeletal Muscle

Thornton, C., Snowden, M. A., & Carling, D. (1998) · Journal of Biological Chemistry

Metabolism, Diabetes, and CancerBiochemical and Molecular Research

Cited by 240

Inhibition of IL-11 signalling extends mammalian healthspan and lifespan

Widjaja, A. A., Lim, W.-W., Viswanathan, S., Chothani, S., Corden, B., Dasan, C. M., Goh, J. W. T., Lim, R., Singh, B. K., Tan, J., et al. (2024) · Nature

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 238

Phosphorylation of AMPK by upstream kinases is required for activity in mammalian cells

Willows, R., Sanders, M. J., Xiao, B., Patel, B. R., Martin, S. R., Read, J., Wilson, J. R., Hubbard, J., Gamblin, S. J., & Carling, D. (2017) · Biochemical Journal

Metabolism, Diabetes, and CancerBiochemical and Molecular Research

Cited by 190

AMP-activated protein kinase: Also regulated by ADP?

Hardie, D. G., Carling, D., & Gamblin, S. J. (2011) · Trends in Biochemical Sciences

Metabolism, Diabetes, and CancerBiochemical and Molecular Research

Cited by 187

Regulation of ploidy and senescence by the AMPK‐related kinase NUAK1

Humbert, N., Navaratnam, N., Augert, A., Da Costa, M., Martien, S., Wang, J., Martinez, D., Abbadie, C., Carling, D., de Launoit, Y., et al. (2010) · The EMBO Journal

Telomeres, Telomerase, and SenescenceHippo pathway signaling and YAP/TAZ

Cited by 115