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Perp Is a Mediator of p53-Dependent Apoptosis in Diverse Cell Types
Open accessAbstract
The induction of apoptosis by the p53 protein is critical for its activity as a tumor suppressor. Although it is clear that p53 induces apoptosis at least in part by direct transcriptional activation of target genes, the set of p53 target genes that mediate p53 function in apoptosis in vivo remains to be well defined. The Perp (p53 apoptosis effector related to PMP-22) gene is highly expressed in cells undergoing p53-dependent apoptosis as compared to cells undergoing p53-dependent G1 arrest. Perp is a direct p53 target, and its overexpression is sufficient to induce cell death in fibroblasts, implicating it as an important component of p53 apoptotic function. Here, through the generation of Perp-deficient mice, we analyze the role of Perp in the p53 apoptosis pathway in multiple primary cell types by comparing the cell death responses of Perp null cells to those of wild-type and p53 null cells. These experiments demonstrate the involvement of Perp in p53-mediated cell death in thymocytes and neurons but not in E1A-expressing MEFs, indicating a cell type-specific role for Perp in the p53 cell death pathway. In addition, we show that Perp is not required for proliferation-associated functions of p53. Thus, Perp selectively mediates the p53 apoptotic response, and the requirement for Perp is dictated by cellular context.
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“PERP is a novel type of effector involved in p53-dependent apoptosis (28).”
From Prediction of the response to chemotherapy in advanced esophageal cancer by gene expression profiling of biopsy samples (2010) · cites this paper as [28]
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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
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Self-citationp53 is required for radiation-induced apoptosis in mouse thymocytes
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Self-citationThymocyte apoptosis induced by p53-dependent and independent pathways
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p63 and p73 are required for p53-dependent apoptosis in response to DNA damage
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Self-citationA subset of p53-deficient embryos exhibit exencephaly
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Self-citation(1993) · PubMed · Cited by 469
PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 familyPreprint
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Self-citationMacleod, K. F., Hu, Y., & Jacks, T. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb01006.x · Cited by 321
Self-citationp53-Dependent Cell Death Signaling in Neurons
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Epithelial Membrane Proteins Induce Membrane Blebbing and Interact with the P2X7 Receptor C Terminus
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Atm and Bax cooperate in ionizing radiation-induced apoptosis in the central nervous system
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The peripheral myelin protein 22 and epithelial membrane protein family
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Mitochondrial membrane permeabilization in cell death
Kroemer, G., Galluzzi, L., & Brenner, C. (2007) · Physiological Reviews · doi:10.1152/physrev.00013.2006 · Cited by 3,598
Distinct p53 Transcriptional Programs Dictate Acute DNA-Damage Responses and Tumor Suppression
Brady, C. A., Jiang, D., Mello, S. S., Johnson, T. M., Jarvis, L. A., Kozak, M. M., Broz, D. K., Basak, S., Park, E. J., McLaughlin, M. E., et al. (2011) · Cell · doi:10.1016/j.cell.2011.03.035 · Cited by 533
Self-citationThe transcriptional targets of p53 in apoptosis control
Yu, J., & Zhang, L. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.03.189 · Cited by 427
Culmsee, C., & Mattson, M. P. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.03.149 · Cited by 397
Perp Is a p63-Regulated Gene Essential for Epithelial Integrity
Ihrie, R. A., Marques, M. R., Nguyen, B., Horner, J. S., Papazoglu, C., Bronson, R. T., Mills, A. A., & Attardi, L. D. (2005) · Cell · doi:10.1016/j.cell.2005.01.008 · Cited by 311
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Metadata
- Authors
- Ihrie, R. A., Reczek, E., Horner, J. S., Khachatrian, L., Sage, J., Jacks, T., & Attardi, L. D.
- Affiliations
- Stanford Medicine (US)
- Massachusetts Institute of Technology (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Attardi, Laura D.
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 2003-11
- Volume
- 13
- Issue
- 22
- Pages
- 1985-1990
- ISSN
- 0960-9822 (ISSN-L)
- OpenAlex
- W2095424453
- Cited by
- 118
- References
- 18
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 2 · 2022: 9 · 2021: 2 · 2020: 4 · 2019: 4 · 2018: 4 · 2017: 6 · 2016: 3 · 2015: 5 · 2014: 2 · 2013: 5 · 2012: 7
- FWCI
- 3.90
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 3546 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Current Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (CA09302, R01CA093665, CA93665-01, T32CA009302)
- Topics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
- Keywords
- PERP, p53, apoptosis, p53 target genes, tumor suppressor, thymocytes, neurons, G1 cell cycle arrest
- MeSH terms
- Animals, Membrane Proteins, Mice, Mutant Strains, Blotting, Southern, Blotting, Northern, Tumor Suppressor Protein p53, Apoptosis, In Situ Nick-End Labeling, Gene Expression Profiling, Mice
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