Cited by 1,985Mitochondrial Function and PathologyAutophagy in Disease and TherapyCell death mechanisms and regulation

The DOI matches its Crossref record; 123 of the 123 references it cites were found in a registry or an index.

Mitochondria: More Than Just a Powerhouse

Open access

McBride, Heidi M., Neuspiel, Margaret, Wasiak, Sylwia·2006·Current Biology

DOI 10.1016/j.cub.2006.06.054

Open this paper in CoChat — free account Open PDF

Abstract

Pioneering biochemical studies have long forged the concept that the mitochondria are the 'energy powerhouse of the cell'. These studies, combined with the unique evolutionary origin of the mitochondria, led the way to decades of research focusing on the organelle as an essential, yet independent, functional component of the cell. Recently, however, our conceptual view of this isolated organelle has been profoundly altered with the discovery that mitochondria function within an integrated reticulum that is continually remodeled by both fusion and fission events. The identification of a number of proteins that regulate these activities is beginning to provide mechanistic details of mitochondrial membrane remodeling. However, the broader question remains regarding the underlying purpose of mitochondrial dynamics and the translation of these morphological transitions into altered functional output. One hypothesis has been that mitochondrial respiration and metabolism may be spatially and temporally regulated by the architecture and positioning of the organelle. Recent evidence supports and expands this idea by demonstrating that mitochondria are an integral part of multiple cell signaling cascades. Interestingly, proteins such as GTPases, kinases and phosphatases are involved in bi-directional communication between the mitochondrial reticulum and the rest of the cell. These proteins link mitochondrial function and dynamics to the regulation of metabolism, cell-cycle control, development, antiviral responses and cell death. In this review we will highlight the emerging evidence that provides molecular definition to mitochondria as a central platform in the execution of diverse cellular events.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.cub.2006.06.054

Cites

123 of 123 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
Cross, D. A. E., Alessi, D. R., Cohen, P., Andjelkovich, M., & Hemmings, B. A. (1995) · Nature · doi:10.1038/378785a0 · Cited by 5,244
Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1
Valente, E. M., Abou-Sleiman, P. M., Caputo, V., Muqit, M. M. K., Harvey, K., Gispert, S., Ali, Z., Del Turco, D., Bentivoglio, A. R., Healy, D. G., et al. (2004) · Science · doi:10.1126/science.1096284 · Cited by 3,481
Rab proteins as membrane organizers
Zerial, M., & McBride, H. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35052055 · Cited by 3,381
Self-citation
Identification and Characterization of MAVS, a Mitochondrial Antiviral Signaling Protein that Activates NF-κB and IRF3
Seth, R. B., Sun, L., Ea, C.-K., & Chen, Z. J. (2005) · Cell · doi:10.1016/j.cell.2005.08.012 · Cited by 3,329
Critical nodes in signalling pathways: insights into insulin action
Taniguchi, C. M., Emanuelli, B., & Kahn, C. R. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1837 · Cited by 2,760
Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development
Chen, H., Detmer, S. A., Ewald, A. J., Griffin, E. E., Fraser, S. E., & Chan, D. C. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200211046 · Cited by 2,601
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
Kawai, T., Takahashi, K., Sato, S., Coban, C., Kumar, H., Kato, H., Ishii, K. J., Takeuchi, O., & Akira, S. (2005) · Nature Immunology · doi:10.1038/ni1243 · Cited by 2,562
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus
Meylan, E., Curran, J., Hofmann, K., Moradpour, D., Binder, M., Bartenschlager, R., & Tschopp, J. (2005) · Nature · doi:10.1038/nature04193 · Cited by 2,401
The p53 pathway: positive and negative feedback loops
Harris, S. L., & Levine, A. J. (2005) · Oncogene · doi:10.1038/sj.onc.1208615 · Cited by 1,967
Dynamin-related Protein Drp1 Is Required for Mitochondrial Division in Mammalian Cells
Smirnova, E., Griparić, L., Shurland, D., & van der Bliek, A. M. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.8.2245 · Cited by 1,938

Flagged first, then by citations

Show all 123 references

Sorted by citations

Items 701–800 of 1,003

Dynamic organization of the mitochondrial protein import machinery
Straub, S. P., Stiller, S. B., Wiedemann, N., & Pfanner, N. (2016) · Biological Chemistry · doi:10.1515/hsz-2016-0145 · Cited by 39
Raman Fiber Photometry for Understanding Mitochondrial Superoxide Burst and Extracellular Calcium Ion Influx upon Acute Hypoxia in the Brain of Freely Moving Animals
Liu, Z., Zhang, Z., Liu, Y., Mei, Y., Feng, E., Liu, Y., Zheng, T., Chen, J., Zhang, S., & Tian, Y. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202111630 · Cited by 36
Nek5 interacts with mitochondrial proteins and interferes negatively in mitochondrial mediated cell death and respiration
Melo‐Hanchuk, T. D., Slepicka, P. F., Guardia, P. G. L., Vercesi, A. E., & Kobarg, J. (2015) · Cellular Signalling · doi:10.1016/j.cellsig.2015.02.021 · Cited by 36
Icaritin acts synergistically with epirubicin to suppress bladder cancer growth through inhibition of autophagy
Pan, X., Li, L., Huang, Y., Huang, H., Xu, D., Gao, Y., Chen, L., Ren, J., Cao, J., Yi, H., et al. (2015) · Oncology Reports · doi:10.3892/or.2015.4335 · Cited by 36
Epithelial Mitochondrial Dysfunction in Lung Disease
Zhang, L., Wang, W. Y., Zhu, B., & Wang, X. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-981-10-6674-0_14 · Cited by 36
Proteomic Analysis of the Myocardium in Hypertrophic Obstructive Cardiomyopathy
COATS, C. J., Heywood, W., Virasami, A. K., Ashrafi, N., Syrris, P., dos Remedios, C. G., Treibel, T. A., Moon, J., Lopes, L. R., McGregor, C. G. A., et al. (2018) · Circulation Genomic and Precision Medicine · doi:10.1161/circgenetics.117.001974 · Cited by 36
The Armadillo Repeat-containing Protein, ARMCX3, Physically and Functionally Interacts with the Developmental Regulatory Factor Sox10
Mou, Z., Tapper, A. R., & Gardner, P. D. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m901177200 · Cited by 36
Comparative analysis of codon usage of mitochondrial genomes provides evolutionary insights into reptiles
Montaña-Lozano, P., Balaguera‐Reina, S. A., & Quiroga, C. F. P. (2022) · Gene · doi:10.1016/j.gene.2022.146999 · Cited by 35
Primary astrocytic mitochondrial transplantation ameliorates ischemic stroke
Lee, E.-H., Kim, M. K., Ko, S. H., Kim, C., Lee, M., & Park, C. (2023) · BMB Reports · doi:10.5483/bmbrep.2022-0108 · Cited by 36
“are essential for cell development, function, and survival (3-5).”
Background
Molecular Mechanisms of Anesthetic Neurotoxicity: A Review of the Current Literature
Jackson, W. M., Gray, C., Jiang, D., Schaefer, M. L., Connor, C., & Mintz, C. D. (2016) · Journal of Neurosurgical Anesthesiology · doi:10.1097/ana.0000000000000348 · Cited by 35
Targeting mitochondrial dysfunction in CNS injury using Methylene Blue; still a magic bullet?
Vekaria, H. J., Watts, L. T., Lin, A., & Sullivan, P. G. (2017) · Neurochemistry International · doi:10.1016/j.neuint.2017.04.004 · Cited by 35
“The role of mitochondria is not only that of the powerhouse of the cell, but is also a dynamic center for cellular homeostasis (McBride et al., 2006).”
Background
Gaseous Signaling Molecules in Cardiovascular Function: From Mechanisms to Clinical Translation
Lee, S. R., Nilius, B., & Han, J. (2018) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/112_2017_7 · Cited by 35
Sensitive Measurement of Mitophagy by Flow Cytometry Using the pH-dependent Fluorescent Reporter mt-Keima
Um, J., Kim, Y. Y., Finkel, T., & Yun, J. (2018) · Journal of Visualized Experiments · doi:10.3791/58099 · Cited by 45
Anticancer and antibacterial activity in vitro evaluation of iridium(III) polypyridyl complexes
Yi, Q.-Y., Zhang, W.-Y., He, M., Du, F., Wang, X., Wang, Y.-J., Gu, Y., Bai, L., & Liu, Y. (2018) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-018-1635-8 · Cited by 35
OPA1-Exon4b Binds to mtDNA D-Loop for Transcriptional and Metabolic Modulation, Independent of Mitochondrial Fusion
Yang, L., Tang, H., Lin, X., Wu, Y., Zeng, S., Pan, Y., Li, Y., Xiang, G., Lin, Y.-F., Zhuang, S., et al. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00180 · Cited by 37
Novel Mitochondria-Targeting and Naphthalimide-based Fluorescent Probe for Detecting HClO in Living Cells
Xu, J., Wang, C., Ma, Q., Zhang, H., Tian, M., Sun, J., Wang, B., & Chen, Y. (2021) · ACS Omega · doi:10.1021/acsomega.1c01271 · Cited by 34
The benefits of exercise for outcome improvement following traumatic brain injury: Evidence, pitfalls and future perspectives
Zhang, Y., Huang, Z., Xia, H., Xiong, J., Ma, X., & Liu, C.-Y. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2021.113958 · Cited by 41
Highlights of New Strategies to Increase the Efficacy of Transition Metal Complexes for Cancer Treatments
Giorgi, E., Binacchi, F., Marotta, C., Cirri, D., Gabbiani, C., & Pratesi, A. (2022) · Molecules · doi:10.3390/molecules28010273 · Cited by 35
“However, mitochondria have many other essential roles, such as biosynthetic metabolism, regulation of cell signalling, ROS neutralization through antioxidant pathways activation, adaptive functions in response to oxidative stress, and cell death induction [79].”
Background
Suppression of Lung Tumorigenesis by Leucine Zipper/EF Hand–Containing Transmembrane-1
Hwang, S., Piao, L., Lim, H.-T., Minai‐Tehrani, A., Yu, K., Ha, Y.-C., Chae, C., Lee, K.-H., Beck, G. R., Park, J., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012535 · Cited by 35
MISC-1/OGC Links Mitochondrial Metabolism, Apoptosis and Insulin Secretion
Gallo, M., Park, D., Luciani, D. S., Kida, K., Palmieri, F., Blacque, O. E., Johnson, J. D., & Riddle, D. L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017827 · Cited by 35
Mitogenome evolution in Cephini (Hymenoptera: Cephidae): Evidence for parallel adaptive evolution
Korkmaz, E. M., Aydemir, H. B., Altun, B. T., Budak, M., & Başıbüyük, H. H. (2017) · Biochemical Systematics and Ecology · doi:10.1016/j.bse.2017.02.004 · Cited by 34
Unraveling Biochemical Pathways Affected by Mitochondrial Dysfunctions Using Metabolomic Approaches
Demine, S., Reddy, N., Renard, P., Raes, M. J., & Arnould, T. (2014) · Metabolites · doi:10.3390/metabo4030831 · Cited by 37
Mitochondria Localize to the Cleavage Furrow in Mammalian Cytokinesis
Lawrence, E. J., & Mandato, C. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072886 · Cited by 35
Role of phospholipase A2s and lipid mediators in secondary damage after spinal cord injury
David, S., Greenhalgh, A. D., & López‐Vales, R. (2012) · Cell and Tissue Research · doi:10.1007/s00441-012-1430-8 · Cited by 34
Rethinking the evolution of eukaryotic metabolism: novel cellular partitioning of enzymes in stramenopiles links serine biosynthesis to glycolysis in mitochondria
Abrahamian, M., Kagda, M. S., Ah‐Fong, A. M. V., & Judelson, H. S. (2017) · BMC Evolutionary Biology · doi:10.1186/s12862-017-1087-8 · Cited by 34
“The red/green signal ratio varied at different sites, which is consistent with observations in other taxa that mitochondria are neither biochemically or structurally uniform [33, 34].”
Background
Mitochondrial genomes of three kissing bugs (Reduviidae: Triatominae) and their phylogenetic implications
Zhao, Y., Jiang, M., Wu, Y., Song, F., Cai, W., & Li, H. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.05.020 · Cited by 34
Mitochondrial Quality Control in the Heart: New Drug Targets for Cardiovascular Disease
Oh, C., Ryu, D., Cho, S., & Jang, Y. (2020) · Korean Circulation Journal · doi:10.4070/kcj.2019.0416 · Cited by 33
Cellular Respiration
Zimmerman, J. J., Arnim, A. V. S. A.-V., & McLaughlin, J. (2011) · Elsevier eBooks · doi:10.1016/b978-0-323-07307-3.10074-6 · Cited by 43
Long-term super-resolution imaging of mitochondrial dynamics
Li, X., Zheng, J., Liu, W., Qiao, Q., Chen, J., Zhou, W., & Xu, Z. (2020) · Chinese Chemical Letters · doi:10.1016/j.cclet.2020.05.043 · Cited by 33
Fluorescent Probes for Selective Recognition of Hypobromous Acid: Achievements and Future Perspectives
Fang, Y., & Dehaen, W. (2021) · Molecules · doi:10.3390/molecules26020363 · Cited by 34
The Emerging Role of FUNDC1-Mediated Mitophagy in Cardiovascular Diseases
Liu, L., Li, Y., & Chen, Q. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.807654 · Cited by 35
Diosgenin Targets CaMKK2 to Alleviate Type II Diabetic Nephropathy through Improving Autophagy, Mitophagy and Mitochondrial Dynamics
Zhong, Y., Jin, R., Luo, R., Liu, J., Ren, L., Zhang, Y., Shan, Z., & Peng, X. (2023) · Nutrients · doi:10.3390/nu15163554 · Cited by 33
“Mitochondria are dynamic and highly motile organelles rather than static and isolated structures [12].”
Background
Long‐term persistence of mitochondrial dysfunctions after viral infections and antiviral therapies: A review of mechanisms involved
Gay, L., Desquiret‐Dumas, V., Nagot, N., Rapenne, C., de Perre, P. V., Reynier, P., & Molès, J. (2024) · Journal of Medical Virology · doi:10.1002/jmv.29886 · Cited by 33
Coordination of the secretory compartments via inter-organelle signalling
Sallese, M., Giannotta, M., & Luini, A. (2009) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2009.04.004 · Cited by 33
New α-Lipoic Acid Derivative, DHL-HisZn, Ameliorates Renal Ischemia-Reperfusion Injury in Rats
Koga, H., Hagiwara, S., Kusaka, J., Goto, K., Uchino, T., Shingu, C., Kai, S., & Noguchi, T. (2011) · Journal of Surgical Research · doi:10.1016/j.jss.2011.01.011 · Cited by 33
Mesenchymal stem cells from preterm to term newborns undergo a significant switch from anaerobic glycolysis to the oxidative phosphorylation
Ravera, S., Podestà, M., Sabatini, F., Fresia, C., Columbaro, M., Bruno, S., Fulcheri, E., Ramenghi, L. A., & Frassoni, F. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2665-z · Cited by 33
Discrete mitochondrial aberrations in the spinal cord of sporadic ALS patients
Delic, V., Kurien, C., Cruz, J., Zivkovic, S., Barretta, J., Thomson, A., Hennessey, D., Joseph, J., Ehrhart, J. C., Willing, A. E., et al. (2018) · Journal of Neuroscience Research · doi:10.1002/jnr.24249 · Cited by 34
Mechanisms of mammalian mitochondrial transcription
Bouda, E., Stapon, A., & García–Díaz, M. (2019) · Protein Science · doi:10.1002/pro.3688 · Cited by 33
RNA binding protein HuD contributes to β-cell dysfunction by impairing mitochondria dynamics
Hong, Y., Tak, H., Kim, C., Kang, H., Ji, E., Ahn, S., Jung, M., Kim, H. L., Lee, J. H., Kim, W., et al. (2019) · Cell Death and Differentiation · doi:10.1038/s41418-019-0447-x · Cited by 34
CNP mediated selective toxicity on melanoma cells is accompanied by mitochondrial dysfunction
Aplak, E., von Montfort, C., Haasler, L., Stucki, D., Steckel, B., Reichert, A. S., Stahl, W., & Brenneisen, P. (2020) · PLoS ONE · doi:10.1371/journal.pone.0227926 · Cited by 33
“Mitochondria, known as the powerhouse of the cell, play an important role in essential processes besides ATP synthesis such as proliferation, differentiation, calcium homeostasis and apoptosis [17, 18].”
Background
Cellular organelle-targeted smart AIEgens in tumor detection, imaging and therapeutics
Luo, G., Xu, T., Li, X., Jiang, W., Duo, Y., & Tang, B. Z. (2022) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2022.214508 · Cited by 33
TOMM34 expression in early invasive breast cancer: a biomarker associated with poor outcome
Aleskandarany, M. A., Negm, O. H., Rakha, E. A., Ahmed, M. A. H., Nolan, C. C., Ball, G., Caldas, C., Green, A. R., Tighe, P. J., & Ellis, I. O. (2012) · Breast Cancer Research and Treatment · doi:10.1007/s10549-012-2249-4 · Cited by 33
Novel mitochondrial extensions provide evidence for a link between microtubule-directed movement and mitochondrial fission
Bowes, T., & Gupta, R. S. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.08.120 · Cited by 33
A mitochondrial CO 2 ‐adenylyl cyclase‐cAMP signalosome controls yeast normoxic cytochrome c oxidase activity
Hess, K. C., Liu, J., Manfredi, G., Mühlschlegel, F. A., Buck, J., Levin, L. R., & Barrientos, A. (2014) · The FASEB Journal · doi:10.1096/fj.14-252890 · Cited by 32
Proteomic Profiling of Mitochondrial Enzymes during Skeletal Muscle Aging
Staunton, L., O’Connell, K. M., & Ohlendieck, K. (2011) · Journal of Aging Research · doi:10.4061/2011/908035 · Cited by 35
Tissue Specific Phosphorylation of Mitochondrial Proteins Isolated from Rat Liver, Heart Muscle, and Skeletal Muscle
Bak, S. Y., León, I. R., Jensen, O. N., & Højlund, K. (2013) · Journal of Proteome Research · doi:10.1021/pr400281r · Cited by 33
Mitoguardin-1 and -2 promote maturation and the developmental potential of mouse oocytes by maintaining mitochondrial dynamics and functions
Liu, X., Zhang, Y.-P., Ji, S., Li, B.-T., Tian, X., Li, D., Tong, C., & Fan, H. (2015) · Oncotarget · doi:10.18632/oncotarget.6713 · Cited by 33
Mitochondrial DNA mitochondrial dysfunction and cardiac manifestations
Han, J. (2017) · Frontiers in bioscience · doi:10.2741/4541 · Cited by 33
Reduced Histone Expression or a Defect in Chromatin Assembly Induces Respiration
Galdieri, L. C., Zhang, T., Rogerson, D., & Vančura, A. (2016) · Molecular and Cellular Biology · doi:10.1128/mcb.00770-15 · Cited by 32
Mitochondrial regulation in the tumor microenvironment: targeting mitochondria for immunotherapy
Ahn, M., Ali, A., & Seo, J. H. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1453886 · Cited by 33
The Mitochondrial Genome Is a “Genetic Sanctuary” during the Oncogenic Process
Seoane, M., Mosquera‐Miguel, A., González, T., Fraga, M., Salas, A., & Costoya, J. A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023327 · Cited by 32
Mechanisms by Which Different Functional States of Mitochondria Define Yeast Longevity
Beach, A., Leonov, A., Arlia‐Ciommo, A., Svistkova, V., Lutchman, V., & Titorenko, V. I. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms16035528 · Cited by 32
Indirubin-3′-oxime induces mitochondrial dysfunction and triggers growth inhibition and cell cycle arrest in human neuroblastoma cells
LIAO, X.-M., & Leung, K. (2012) · Oncology Reports · doi:10.3892/or.2012.2094 · Cited by 31
Inner membrane fusion mediates spatial distribution of axonal mitochondria
Yu, Y., Lee, H.-C., Chen, K.-C., Suhan, J. P., Qiu, M., Ba, Q., & Yang, G. (2016) · Scientific Reports · doi:10.1038/srep18981 · Cited by 32
MicroRNA-33/33* inhibit the activation of MAVS through AMPK in antiviral innate immunity
Liu, D., Tan, Q., Zhu, J., Zhang, Y., Xue, Y., Song, Y., Liu, Y., Wang, Q., & Lai, L. (2019) · Cellular and Molecular Immunology · doi:10.1038/s41423-019-0326-x · Cited by 32
Insights Into the Role of Mitochondrial Ion Channels in Inflammatory Response
Ponnalagu, D., & Singh, H. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00258 · Cited by 32
Aflatoxin B1-Induced COX-2 Expression Promotes Mitophagy and Contributes to Lipid Accumulation in Hepatocytes In Vitro and In Vivo
Ren, X., Han, P., & Meng, Y. (2020) · International Journal of Toxicology · doi:10.1177/1091581820939081 · Cited by 32
“Normal mitochondrial function is critical to maintaining the body’s need for energy metabolism.(34) Consecutively, the dynamic regulation of the normal mitochondria ensures that cells respond effectively to complex and variable intracellular environments.”
Background
Aggregation‐induced Emission Based Fluorogens for Mitochondria‐targeted Tumor Imaging and Theranostics
Yu, K., Pan, J., Husamelden, E., Zhang, H., He, Q., Wei, Y., & Tian, M. (2020) · Chemistry - An Asian Journal · doi:10.1002/asia.202001100 · Cited by 32
The mitogenomes of two saprophytic Boletales species ( Coniophora ) reveals intron dynamics and accumulation of plasmid-derived and non-conserved genes
Wu, P., Bao, Z., Tu, W., Li, L., Xiong, C., Jin, X., Li, P., Gui, M., Huang, W., & Li, Q. (2020) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2020.12.041 · Cited by 32
Puerarin alleviates cadmium-induced mitochondrial mass decrease by inhibiting PINK1–Parkin and Nix-mediated mitophagy in rat cortical neurons
Wen, S., Wang, L., Wang, T., Xu, M., Zhang, W., Song, R., Zou, H., Gu, J., Bian, J., Yuan, Y., et al. (2021) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2021.113127 · Cited by 32
Mitochondria-Targeted Luminescent Organotin(IV) Complexes: Synthesis, Photophysical Characterization, and Live Cell Imaging
Patra, S. A., Sahu, G., Pattanayak, P. D., Sasamori, T., & Dinda, R. (2022) · Inorganic Chemistry · doi:10.1021/acs.inorgchem.2c02959 · Cited by 32
Depletion of end-binding protein 1 (EB1) promotes apoptosis of human non-small-cell lung cancer cells via reactive oxygen species and Bax-mediated mitochondrial dysfunction
Kim, M.-J., Yun, H. S., Hong, E., Lee, S., Baek, J., Lee, C., Yim, J.-H., Kim, J., Park, J. K., Um, H., et al. (2013) · Cancer Letters · doi:10.1016/j.canlet.2013.07.027 · Cited by 32
Arabidopsis thaliana organellar DNA polymerase IB mutants exhibit reduced mtDNA levels with a decrease in mitochondrial area density
Cupp, J. D., & Nielsen, B. L. (2012) · Physiologia Plantarum · doi:10.1111/ppl.12009 · Cited by 36
The ArabidopsisRETARDED ROOT GROWTHGene Encodes a Mitochondria-Localized Protein That Is Required for Cell Division in the Root Meristem
Zhou, X., Li, Q., Chen, X., Liu, J., Zhang, Q., Liu, Y., Liu, K., & Xu, J. (2011) · PLANT PHYSIOLOGY · doi:10.1104/pp.111.185827 · Cited by 32
Promising Genetic Biomarkers of Preclinical Alzheimer's Disease: The Influence ofAPOEandTOMM40on Brain Integrity
Ferencz, B., Karlsson, S., & Kalpouzos, G. (2012) · International Journal of Alzheimer s Disease · doi:10.1155/2012/421452 · Cited by 35
Protein instability and functional defects caused by mutations of dihydro-orotate dehydrogenase in Miller syndrome patients
Fang, J., Uchiumi, T., Yagi, M., Matsumoto, S., Amamoto, R., Saito, T., Takazaki, S., Kanki, T., Yamaza, H., Nonaka, K., et al. (2012) · Bioscience Reports · doi:10.1042/bsr20120046 · Cited by 32
Mitochondrial DNA Heteroplasmy in Candida glabrata after Mitochondrial Transformation
Zhou, J., Liu, L., & Chen, J. (2010) · Eukaryotic Cell · doi:10.1128/ec.00349-09 · Cited by 36
Mitochondrial Mutations in Cardiac Disorders
Lee, S. R., & Han, J. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-55330-6_5 · Cited by 33
Sulforaphane rescues memory dysfunction and synaptic and mitochondrial alterations induced by brain iron accumulation
Lavich, I. C., de Freitas, B. S., Kist, L. W., Falavigna, L., Dargél, V. A., Köbe, L. M., Aguzzoli, C. S., Piffero, B., Florian, P. Z., Bogo, M. R., et al. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.06.025 · Cited by 32
Deficiency of the mitochondrial ribosomal subunit, MRPL50, causes autosomal recessive syndromic premature ovarian insufficiency
Bakhshalizadeh, S., Hock, D. H., Siddall, N. A., Kline, B. L., Sreenivasan, R., Bell, K. M., Casagranda, F., Kamalanathan, S., Sahoo, J., Narayanan, N., et al. (2023) · Human Genetics · doi:10.1007/s00439-023-02563-z · Cited by 30
“1 3 supplying energy, mitochondria also have essential roles in the regulation of cellular pathways including amino acid metabolism, steroid hormone biogenesis, phospholipid biosynthesis, programmed cell death, calcium homeostasis, generation of reactive oxygen species (ROS) and antioxidant protection (McBride et al.…”
Background
Codon usage characterization and phylogenetic analysis of the mitochondrial genome in Hemerocallis citrina
Zhang, K., Wang, Y., Zhang, Y., & Shan, X. (2024) · BMC Genomic Data · doi:10.1186/s12863-024-01191-4 · Cited by 31
“Mitochondria (mt) are semiautonomous energy-pro-ducing eukaryotic organelles that drive oxidative phosphorylation for energy metabolism [23].”
Background
Pesticide immunotoxicity on insects – Are agroecosystems at risk?
Lisi, F., Amichot, M., Desneux, N., Gatti, J., Guedes, R. N. C., Nazzi, F., Pennacchio, F., Russo, A., Sánchez‐Bayo, F., Wang, X., et al. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.175467 · Cited by 31
The Role of Oxidative Stress in Periodontitis
Bullón, P., Giampieri, F., Bullón, B., & Battino, M. A. (2025) · Journal of Periodontal Research · doi:10.1111/jre.70016 · Cited by 32
T-cell-restricted intracellular antigen 1 facilitates mitochondrial fragmentation by enhancing the expression of mitochondrial fission factor
Tak, H., Eun, J. W., Kim, J., Park, S. J., Kim, C., Ji, E., Lee, H., Kang, H., Cho, D., Lee, K., et al. (2016) · Cell Death and Differentiation · doi:10.1038/cdd.2016.90 · Cited by 31
“Mitochondria execute pivotal roles in the regulation of energy metabolism, calcium signaling, and apoptosis, and dysfunction of mitochondria is related to the pathogenesis of several diseases.(1,3,5,49) Dynamic regulation of mitochondria is essential for the maintenance of cellular homeostasis and is governed by sever…”
Background
Omega-3 fatty acids inhibit oxidative stress in a rat model of liver regeneration
Fırat, Ö., Makay, Ö., Yenıay, L., Gökçe, G., Yenisey, Ç., & Çöker, A. (2017) · Annals of Surgical Treatment and Research · doi:10.4174/astr.2017.93.1.1 · Cited by 31
“On the other hand, the importance of protecting the mito chondria is more than maintaining the energy source of the cell; since this organelle has been involved in a range of other processes, such as signaling, cellular differentiation, cell death, as well as the control of the cell cycle and cell growth [30].”
Background
Regulation of mitophagy by the ubiquitin pathway in neurodegenerative diseases
Desai, S. D., Juncker, M. A., & Kim, C. (2018) · Experimental Biology and Medicine · doi:10.1177/1535370217752351 · Cited by 31
Stereoisomer-specific ginsenoside 20(S)-Rg3 reverses replicative senescence of human diploid fibroblasts via Akt-mTOR-Sirtuin signaling
Yang, K.-E., Jang, H.-J., Hwang, I., Hong, E. M., Lee, M. G., Lee, S., Jang, I., & Choi, J.-S. (2019) · Journal of Ginseng Research · doi:10.1016/j.jgr.2019.08.002 · Cited by 31
The First Mitochondrial Genome for Geastrales (Sphaerobolus stellatus) Reveals Intron Dynamics and Large-Scale Gene Rearrangements of Basidiomycota
Ye, J., Cheng, J., Ren, Y., Liao, W., & Li, Q. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.01970 · Cited by 31
Metformin - its anti-cancer effects in hematologic malignancies
Podhorecka, M. (2021) · Oncology Reviews · doi:10.4081/oncol.2021.514 · Cited by 32
USP30-AS1 contributes to mitochondrial quality control in glioblastoma cells
Wang, N., Li, J., Xin, Q., & Xu, N. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2021.10.006 · Cited by 31
Novel mitochondrial genome rearrangements including duplications and extensive heteroplasmy could underlie temperature adaptations in Antarctic notothenioid fishes
Minhas, B. F., Beck, E. A., Cheng, C. ‐. C., & Catchen, J. (2023) · Scientific Reports · doi:10.1038/s41598-023-34237-1 · Cited by 31
“Mitochondria are known to have a role in the adaptation to changing environmental conditions because of their significance in important life processes (McBride et al., 2006; Sokolova, 2018).”
Background
Drosophila cyclin D/Cdk4 regulates mitochondrial biogenesis and aging and sensitizes animals to hypoxic stress
Icreverzi, A., de la Cruz, A. F., Voorhies, W. A. V., & Edgar, B. A. (2012) · Cell Cycle · doi:10.4161/cc.11.3.19062 · Cited by 31
FAM5C Contributes to Aggressive Periodontitis
Carvalho, F. M., Tinoco, E. M. B., Deeley, K. B., Duarte, P. M., Faveri, M., Marques, M. R., de Mendonça, A. C., Wang, X., Cuenco, K. T., Menezes, R., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010053 · Cited by 31
Carnosic Acid Suppresses the H2O2-Induced Mitochondria-Related Bioenergetics Disturbances and Redox Impairment in SH-SY5Y Cells: Role for Nrf2
de Oliveira, M. R., Ferreira, G. C., Peres, A., & Bosco, S. M. D. (2017) · Molecular Neurobiology · doi:10.1007/s12035-016-0372-7 · Cited by 32
Efferocytosis by bone marrow mesenchymal stromal cells disrupts osteoblastic differentiation via mitochondrial remodeling
Quarato, E. R., Salama, N., Li, A. J., Smith, C. O., Zhang, J., Kawano, Y., McArthur, M. J., Liesveld, J. L., Becker, M. W., Elliott, M. R., et al. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05931-9 · Cited by 30
Mechanisms and therapeutic targets of carbon monoxide poisoning: A focus on reactive oxygen species
Wang, T., & Zhang, Y. (2024) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2024.111223 · Cited by 33
Nicotinamide mononucleotide supplementation rescues mitochondrial and energy metabolism functions and ameliorates inflammatory states in the ovaries of aging mice
Liang, J., Huang, F., Hao, X., Zhang, P., & Chen, R. (2024) · MedComm · doi:10.1002/mco2.727 · Cited by 33
In Vitro and in Vivo Trypanosomicidal Activity of Pyrazole-Containing Macrocyclic and Macrobicyclic Polyamines: Their Action on Acute and Chronic Phases of Chagas Disease
Sánchez‐Moreno, M., Marı́n, C., Navarro, P., Lamarque, L., García‐España, E., Miranda, C., Huertas, Ó., Olmo, F., Gómez-Contreras, F., Pitarch‐Jarque, J., et al. (2012) · Journal of Medicinal Chemistry · doi:10.1021/jm2017144 · Cited by 30
Identification of a Degradation Signal Sequence within Substrates of the Mitochondrial i-AAA Protease
Rampello, A. J., & Glynn, S. E. (2017) · Journal of Molecular Biology · doi:10.1016/j.jmb.2017.02.009 · Cited by 30
“3 Introduction Mitochondria are multifunctional organelles that integrate essential activities in eukaryotic cells such as ATP production, calcium signaling, and apoptosis [1, 2].”
Background
Low mitochondrial activity within developing earthworm male germ-line cysts revealed by JC-1
Małota, K., Student, S., & Świątek, P. (2018) · Mitochondrion · doi:10.1016/j.mito.2018.01.007 · Cited by 30
Methylene Blue Protects Against Sevoflurane-Induced Cognitive Dysfunction by Suppressing Drp1 deSUMOylation in Aged Mice
Zheng, F., Fang, P., Chang, J., Chen, M., Zhong, Q., Chen, T., Chen, C., & Zhang, Z. (2020) · Neurochemical Research · doi:10.1007/s11064-020-02976-6 · Cited by 30
Inhibition of Src Family Kinases Ameliorates LPS-Induced Acute Kidney Injury and Mitochondrial Dysfunction in Mice
Pak, E. S., Uddin, M. J., & Ha, H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218246 · Cited by 30
“Mitochondria are important organelles that supply cellular energy [19].”
Background
Mitochondria and nucleus cross‐talk: Signaling in metabolism, apoptosis, and differentiation, and function in cancer
Shteinfer‐Kuzmine, A., Verma, A., Arif, T., Aizenberg, O., Paul, A., & Shoshan‐Barmatz, V. (2020) · IUBMB Life · doi:10.1002/iub.2407 · Cited by 31
Prevalence of Genetically Complex Leishmania Strains With Hybrid and Mito-Nuclear Discordance
Kato, H., Cáceres, A. G., Gómez, E. A., Tabbabi, A., Mizushima, D., Yamamoto, D. S., & Hashiguchi, Y. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.625001 · Cited by 30
“Although mitochondria contain their own DNA independently, the interaction between mitochondrial and nuclear genomes is important for biological functions of the cell (McBride et al., 2006; Ali et al., 2019).”
Background
Development of reaction-free and mitochondrion-immobilized fluorescent probe for monitoring pH change
Guo, L., Liu, H., Jin, X. Y., Zhang, Z., Su, J., & Yu, X. (2021) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2021.129962 · Cited by 30
Intrinsic Mechanisms Underlying Hypoxia-Tolerant Mitochondrial Phenotype During Hypoxia-Reoxygenation Stress in a Marine Facultative Anaerobe, the Blue Mussel Mytilus edulis
Sokolov, E. P., Adzigbli, L., Markert, S., Bundgaard, A., Fago, A., Becher, D., Hirschfeld, C., & Sokolova, I. M. (2021) · Frontiers in Marine Science · doi:10.3389/fmars.2021.773734 · Cited by 31
Dichotomy in hypoxia-induced mitochondrial fission in placental mesenchymal cells during development and preeclampsia: consequences for trophoblast mitochondrial homeostasis
Gillmore, T., Farrell, A., Alahari, S., Sallais, J., Kurt, M., Park, C., Ausman, J., Litvack, M. L., Post, M., & Caniggia, I. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04641-y · Cited by 31
“INTRODUCTION Mitochondria are critical organelles responsible for cell survival and death [1, 2].”
Defining Mitochondrial Cristae Morphology Changes Induced by Aging in Brown Adipose Tissue
Crabtree, A., Neikirk, K., Marshall, A. G., Vang, L., Whiteside, A. J., Williams, Q., Altamura, C. T., Owens, T. C., Stephens, D. C., Shao, B., et al. (2023) · Advanced Biology · doi:10.1002/adbi.202300186 · Cited by 31
Tauroursodeoxycholic acid increases neural stem cell pool and neuronal conversion by regulating mitochondria-cell cycle retrograde signaling
Xavier, J. M., Morgado, A. L., Rodrigues, C. M., & Solá, S. (2014) · Cell Cycle · doi:10.4161/15384101.2014.962951 · Cited by 30
Remodelling of Ca2+ handling organelles in adult rat ventricular myocytes during long term culture
Hammer, K. P., Ruppenthal, S., Viéro, C., Scholz, A., Edelmann, L., Kaestner, L., & Lipp, P. (2010) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2010.05.010 · Cited by 30

Authors: McBride, H. M., Neuspiel, M., & Wasiak, S.
Affiliations: Ottawa Heart Institute (CA)
Corresponding author: McBride, Heidi M.
ORCID: McBride, Heidi M.
Wasiak, Sylwia
Venue: Current Biology
Publisher: Elsevier BV
Published: 2006-07
Volume: 16
Issue: 14
Pages: R551-R560
ISSN: 0960-9822 (ISSN-L)
DOI: 10.1016/j.cub.2006.06.054
OpenAlex: W2084034472
Cited by: 1,985
References: 123
Citations by year: 2026: 48 · 2025: 95 · 2024: 129 · 2023: 126 · 2022: 127 · 2021: 132 · 2020: 130 · 2019: 102 · 2018: 97 · 2017: 125 · 2016: 126 · 2015: 115 · 2014: 100 · 2013: 116 · 2012: 92
FWCI: 4.22
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 2573 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Current Biology (publishedVersion)
PubMed (publishedVersion)
Funders: Canadian Institutes of Health Research
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Keywords: mitochondria, mitochondrial dynamics, mitochondrial fusion, mitochondrial fission, mitochondrial reticulum, mitochondrial membrane remodeling, mitochondrial respiration, mitochondrial metabolism, signal transduction, GTPase, kinases, phosphatase, cell death, cell cycle regulation, antiviral response, organelle positioning
MeSH terms: Cell Division, Mitochondria, Models, Biological, Neurons, Phosphoric Monoester Hydrolases, Protein Kinases, Signal Transduction, Tumor Suppressor Protein p53, NF-kappa B, Apoptosis, ras Proteins, Mitochondrial Proteins, Mitochondrial Membranes

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Mitochondria: More Than Just a Powerhouse

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks