IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
Abstract
Type I interferons are central mediators for antiviral responses. Using high-throughput functional screening of interferon inducers, we have identified here a molecule we call interferon-beta promoter stimulator 1 (IPS-1). Overexpression of IPS-1 induced type I interferon and interferon-inducible genes through activation of IRF3, IRF7 and NF-kappaB transcription factors. TBK1 and IKKi protein kinases were required for the IPS-1-mediated interferon induction. IPS-1 contained an N-terminal CARD-like structure that mediated interaction with the CARD of RIG-I and Mda5, which are cytoplasmic RNA helicases that sense viral infection. 'Knockdown' of IPS-1 by small interfering RNA blocked interferon induction by virus infection. Thus, IPS-1 is an adaptor involved in RIG-I- and Mda5-mediated antiviral immune responses.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
MAVS localization to the outer mitochondrial membrane is indispensable for its function in RLR signaling.
“A breakthrough in establishing the role for mitochondria in RLR-activated antiviral immunity was the identification of the RLR mitochondrial adaptor protein MAVS (mitochondrial antiviral-signaling protein)(Kawai et al., 2005; Meylan et al., 2005; Seth et al., 2005; Xu et al., 2005) localization to the outer mitochondrial membrane is indispensable for its function.”
From Mitochondria in the Regulation of Innate and Adaptive Immunity (2015) · cites this paper as Kawai et al., 2005
RIG-I is critical for type I IFN transcription during viral infection.
“RIG-I is critical for type I IFN transcription during viral infection (76).”
From Into the Eye of the Cytokine Storm (2012) · cites this paper as [76]
Cites
Janeway, C. A., & Medzhitov, R. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.083001.084359 · Cited by 8,394 · see citing works
Akira, S., & Takeda, K. (2004) · Nature reviews. Immunology · doi:10.1038/nri1391 · Cited by 8,312 · see citing works
Self-citationTakeda, K., Kaisho, T., & Akira, S. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141126 · Cited by 6,143 · see citing works
Self-citationRecognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3
Alexopoulou, L., Holt, A. C., Medzhitov, R., & Flavell, R. A. (2001) · Nature · doi:10.1038/35099560 · Cited by 6,129 · see citing works
Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8
Heil, F., Hemmi, H., Hochrein, H., Ampenberger, F., Kirschning, C., Akira, S., Lipford, G., Wagner, H., & Bauer, S. (2004) · Science · doi:10.1126/science.1093620 · Cited by 3,947 · see citing works
Self-citationYoneyama, M., Kikuchi, M., Natsukawa, T., Shinobu, N., Imaizumi, T., Miyagishi, M., Taira, K., Akira, S., & Fujita, T. (2004) · Nature Immunology · doi:10.1038/ni1087 · Cited by 3,935 · see citing works
Self-citationInnate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
Diebold, S. S., Kaisho, T., Hemmi, H., Akira, S., & Reis e Sousa, C. (2004) · Science · doi:10.1126/science.1093616 · Cited by 3,444 · see citing works
Self-citationRole of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway
Yamamoto, M., Sato, S., Hemmi, H., Hoshino, K., Kaisho, T., Sanjo, H., Takeuchi, O., Sugiyama, M., Okabe, M., Takeda, K., et al. (2003) · Science · doi:10.1126/science.1087262 · Cited by 3,244 · see citing works
Self-citationIKKε and TBK1 are essential components of the IRF3 signaling pathway
Fitzgerald, K. A., McWhirter, S. M., Faia, K. L., Rowe, D. C., Latz, E., Golenbock, D. T., Coyle, A. J., Liao, S.-M., & Maniatis, T. (2003) · Nature Immunology · doi:10.1038/ni921 · Cited by 2,680 · see citing works
Triggering the Interferon Antiviral Response Through an IKK-Related Pathway
Sharma, S., tenOever, B. R., Grandvaux, N., Zhou, G., Lin, R., & Hiscott, J. B. (2003) · Science · doi:10.1126/science.1081315 · Cited by 1,664 · see citing works
Cell Type-Specific Involvement of RIG-I in Antiviral Response
Kato, H., Sato, S., Yoneyama, M., Yamamoto, M., Uematsu, S., Matsui, K., Tsujimura, T., Takeda, K., Fujita, T., Takeuchi, O., et al. (2005) · Immunity · doi:10.1016/j.immuni.2005.04.010 · Cited by 1,368 · see citing works
Self-citationYamamoto, M., Sato, S., Mori, K., Hoshino, K., Takeuchi, O., Takeda, K., & Akira, S. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.12.6668 · Cited by 1,227 · see citing works
Self-citationOshiumi, H., Matsumoto, M., Funami, K., Akazawa, T., & Seya, T. (2003) · Nature Immunology · doi:10.1038/ni886 · Cited by 1,208 · see citing works
Kawai, T., Sato, S., Ishii, K. J., Coban, C., Hemmi, H., Yamamoto, M., Terai, K., Matsuda, M., Inoue, J., Uematsu, S., et al. (2004) · Nature Immunology · doi:10.1038/ni1118 · Cited by 1,038 · see citing works
Self-citationAndrejeva, J., Childs, K., Young, D. F., Carlos, T. S., Stock, N., Goodbourn, S., & Randall, R. E. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407639101 · Cited by 990 · see citing works
Sumpter, R., Loo, Y., Foy, E. M., Li, K., Yoneyama, M., Fujita, T., Lemon, S. M., & Gale, M. (2005) · Journal of Virology · doi:10.1128/jvi.79.5.2689-2699.2005 · Cited by 900 · see citing works
RIP1 is an essential mediator of Toll-like receptor 3–induced NF-κB activation
Meylan, E., Burns, K., Hofmann, K., Blancheteau, V., Martinon, F., Kelliher, M. A., & Tschopp, J. (2004) · Nature Immunology · doi:10.1038/ni1061 · Cited by 848 · see citing works
Sato, S., Sugiyama, M., Yamamoto, M., Watanabe, Y., Kawai, T., Takeda, K., & Akira, S. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.8.4304 · Cited by 709 · see citing works
Self-citationNF‐κB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK‐related kinase
Pomerantz, J. L., & Baltimore, D. (1999) · The EMBO Journal · doi:10.1093/emboj/18.23.6694 · Cited by 595 · see citing works
Hemmi, H., Takeuchi, O., Sato, S., Yamamoto, M., Kaisho, T., Sanjo, H., Kawai, T., Hoshino, K., Takeda, K., & Akira, S. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040520 · Cited by 576 · see citing works
Self-citationMcWhirter, S. M., Fitzgerald, K. A., Rosains, J., Rowe, D. C., Golenbock, D. T., & Maniatis, T. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2237236100 · Cited by 540 · see citing works
Honda, K., Yanai, H., Mizutani, T., Negishi, H., Shimada, N., Suzuki, N., Ohba, Y., Takaoka, A., Yeh, W., & Taniguchi, T. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406933101 · Cited by 526 · see citing works
Uematsu, S., Sato, S., Yamamoto, M., Hirotani, T., Kato, H., Takeshita, F., Matsuda, M., Coban, C., Ishii, K. J., Kawai, T., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20042372 · Cited by 488 · see citing works
Self-citationHoebe, K. H. N., Janssen, E. M., Kim, S. O., Alexopoulou, L., Flavell, R. A., Han, J., & Beutler, B. (2003) · Nature Immunology · doi:10.1038/ni1010 · Cited by 444 · see citing works
Perry, A. K., Chow, E. K., Goodnough, J. B., Yeh, W., & Cheng, G. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040528 · Cited by 399 · see citing works
Matsuda, A., Suzuki, Y., Honda, G., Muramatsu, S., Matsuzaki, O., Nagano, Y., Doi, T., Shimotohno, K., Harada, T., Nishida, E., et al. (2003) · Oncogene · doi:10.1038/sj.onc.1206406 · Cited by 395 · see citing works
Hemmi, H., Kaisho, T., Takeda, K., & Akira, S. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.6.3059 · Cited by 338 · see citing works
Self-citationA FADD-dependent innate immune mechanism in mammalian cells
Balachandran, S., Thomas, E., & Barber, G. N. (2004) · Nature · doi:10.1038/nature03124 · Cited by 294 · see citing works
Differential involvement of IFN- in Toll-like receptor-stimulated dendritic cell activation
Hoshino, K., Kaisho, T., Iwabe, T., Takeuchi, O., & Akira, S. (2002) · International Immunology · doi:10.1093/intimm/dxf089 · Cited by 282 · see citing works
Self-citationCARD11 mediates factor‐specific activation of NF‐κB by the T cell receptor complex
Pomerantz, J. L., Denny, E. M., & Baltimore, D. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf505 · Cited by 211 · see citing works
Stockinger, S., Reutterer, B., Schaljo, B., Schellack, C., Brunner, S., Materna, T., Yamamoto, M., Akira, S., Taniguchi, T., Murray, P. J., et al. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.12.7416 · Cited by 198 · see citing works
Self-citationBreiman, A., Grandvaux, N., Lin, R., Ottone, C., Akira, S., Yoneyama, M., Fujita, T., Hiscott, J. B., & MEURS, E. F. (2005) · Journal of Virology · doi:10.1128/jvi.79.7.3969-3978.2005 · Cited by 168 · see citing works
Self-citationKopp, E. B. (2004) · Medical Entomology and Zoology · Cited by 160 · see citing works
Kovacsovics, M., Martinon, F., Micheau, O., Bodmer, J.-L., Hofmann, K., & Tschopp, J. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00842-4 · Cited by 136 · see citing works
Sasai, M., Oshiumi, H., Matsumoto, M., Inoue, N., Fujita, F., Nakanishi, M., & Seya, T. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.1.27 · Cited by 135 · see citing works
NF‐κB activation through IKK‐i‐dependent I‐TRAF/TANK phosphorylation
Nomura, Kawai, T., Nakanishi, K., & Akira, S. (2000) · Genes to Cells · doi:10.1046/j.1365-2443.2000.00315.x · Cited by 102 · see citing works
Self-citationO’Connell, R. M., Vaidya, S. A., Perry, A. K., Saha, S. K., Dempsey, P. W., & Cheng, G. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.3.1602 · Cited by 86 · see citing works
CpG RNA: Identification of Novel Single-Stranded RNA That Stimulates Human CD14+CD11c+ Monocytes
Sugiyama, T., Gürsel, M., Takeshita, F., Coban, C., Conover, J., Kaisho, T., Akira, S., Klinman, D. M., & Ishii, K. J. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.4.2273 · Cited by 80 · see citing works
Self-citationJayakar, H. R., & Whitt, M. A. (2002) · Journal of Virology · doi:10.1128/jvi.76.16.8011-8018.2002 · Cited by 80 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Pathogen Recognition and Innate Immunity
Akira, S., Uematsu, S., & Takeuchi, O. (2006) · Cell · doi:10.1016/j.cell.2006.02.015 · Cited by 11,974 · see citing works
Self-citationDifferential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
Kato, H., Takeuchi, O., Sato, S., Yoneyama, M., Yamamoto, M., Matsui, K., Uematsu, S., Jung, A., Kawai, T., Ishii, K. J., et al. (2006) · Nature · doi:10.1038/nature04734 · Cited by 3,888 · see citing works
Self-citationSTING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
Ishikawa, H., & Barber, G. N. (2008) · Nature · doi:10.1038/nature07317 · Cited by 3,576 · see citing works
Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses
Mogensen, T. H. (2009) · Clinical Microbiology Reviews · doi:10.1128/cmr.00046-08 · Cited by 3,122 · see citing works
Interferon-stimulated genes: A complex web of host defenses
Schneider, W. M., Chevillotte, M. D., & Rice, C. M. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120231 · Cited by 3,067 · see citing works
STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
Ishikawa, H., Ma, Z., & Barber, G. N. (2009) · Nature · doi:10.1038/nature08476 · Cited by 2,759 · see citing works
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus
Meylan, E., Curran, J., Hofmann, K., Moradpour, D., Binder, M., Bartenschlager, R., & Tschopp, J. (2005) · Nature · doi:10.1038/nature04193 · Cited by 2,401 · see citing works
Signaling to NF-κB by Toll-like receptors
Kawai, T., & Akira, S. (2007) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2007.09.002 · Cited by 2,395 · see citing works
Self-citationPathogen Recognition by the Innate Immune System
Kumar, H., Kawai, T., & Akira, S. (2011) · International Reviews of Immunology · doi:10.3109/08830185.2010.529976 · Cited by 2,264 · see citing works
Self-citationTargeting NF-κB pathway for the therapy of diseases: mechanism and clinical study
Yu, H., Lin, L., Zhang, Z., Zhang, H., & Hu, H. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00312-6 · Cited by 2,236 · see citing works
Mitochondria: More Than Just a Powerhouse
McBride, H. M., Neuspiel, M., & Wasiak, S. (2006) · Current Biology · doi:10.1016/j.cub.2006.06.054 · Cited by 1,985 · see citing works
Into the Eye of the Cytokine Storm
Tisoncik, J. R., Korth, M. J., Simmons, C. P., Farrar, J., Martin, T. R., & Katze, M. G. (2012) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.05015-11 · Cited by 1,940 · see citing works
Innate immune recognition of viral infection
Kawai, T., & Akira, S. (2006) · Nature Immunology · doi:10.1038/ni1303 · Cited by 1,899 · see citing works
Self-citationImmune Signaling by RIG-I-like Receptors
Loo, Y.-M., & Gale, M. (2011) · Immunity · doi:10.1016/j.immuni.2011.05.003 · Cited by 1,875 · see citing works
Kawai, T., & Akira, S. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401850 · Cited by 1,817 · see citing works
Self-citationTRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity
Gack, M. U., Shin, Y. C., Joo, C.-H., Urano, T., Liang, C., Sun, L., Takeuchi, O., Akira, S., Chen, Z. J., Inoue, S., et al. (2007) · Nature · doi:10.1038/nature05732 · Cited by 1,683 · see citing works
Self-citationHonda, K., & Taniguchi, T. (2006) · Nature reviews. Immunology · doi:10.1038/nri1900 · Cited by 1,676 · see citing works
The roles of TLRs, RLRs and NLRs in pathogen recognition
Kawai, T., & Akira, S. (2009) · International Immunology · doi:10.1093/intimm/dxp017 · Cited by 1,666 · see citing works
Self-citationKato, H., Takeuchi, O., Mikamo, E., Hirai, R., Kawai, T., Matsushita, K., Hiiragi, A., Dermody, T. S., Fujita, T., & Akira, S. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080091 · Cited by 1,590 · see citing works
Self-citationRandall, R. E., & Goodbourn, S. (2007) · Journal of General Virology · doi:10.1099/vir.0.83391-0 · Cited by 1,559 · see citing works
The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation
Zhong, B., Yang, Y., Li, S., Wang, Y., Li, Y., Diao, F., Lei, C., He, X., Zhang, L., Tien, P., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.09.003 · Cited by 1,513 · see citing works
Innate Immune Pattern Recognition: A Cell Biological Perspective
Brubaker, S. W., Bonham, K. S., Zanoni, I., & Kagan, J. C. (2015) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032414-112240 · Cited by 1,475 · see citing works
Type I Inteferon Gene Induction by the Interferon Regulatory Factor Family of Transcription Factors
Honda, K., Takaoka, A., & Taniguchi, T. (2006) · Immunity · doi:10.1016/j.immuni.2006.08.009 · Cited by 1,386 · see citing works
Mitochondria in innate immune responses
West, A. P., Shadel, G. S., & Ghosh, S. (2011) · Nature Reviews Immunology · doi:10.1038/nri2975 · Cited by 1,376 · see citing works
Replication of hepatitis C virus
Moradpour, D., Pénin, F., & Rice, C. M. (2007) · Nature Reviews Microbiology · doi:10.1038/nrmicro1645 · Cited by 1,337 · see citing works
STING Specifies IRF3 Phosphorylation by TBK1 in the Cytosolic DNA Signaling Pathway
Tanaka, Y., & Chen, Z. J. (2012) · Science Signaling · doi:10.1126/scisignal.2002521 · Cited by 1,314 · see citing works
Hou, F., Sun, L., Zheng, H., Skaug, B. A., Jiang, Q., & Chen, Z. J. (2011) · Cell · doi:10.1016/j.cell.2011.06.041 · Cited by 1,274 · see citing works
Regulation and Function of IKK and IKK-Related Kinases
Häcker, H., & Karin, M. (2006) · Science s STKE · doi:10.1126/stke.3572006re13 · Cited by 1,269 · see citing works
The IRF Family Transcription Factors in Immunity and Oncogenesis
Tamura, T., Yanai, H., Savitsky, D., & Taniguchi, T. (2008) · Annual Review of Immunology · doi:10.1146/annurev.immunol.26.021607.090400 · Cited by 1,259 · see citing works
Innate immunity to virus infection
Takeuchi, O., & Akira, S. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00737.x · Cited by 1,231 · see citing works
Self-citationIntracellular pattern recognition receptors in the host response
Meylan, E., Tschopp, J., & Karin, M. (2006) · Nature · doi:10.1038/nature04946 · Cited by 1,196 · see citing works
Type I Interferons in Host Defense
Stetson, D. B., & Medzhitov, R. M. (2006) · Immunity · doi:10.1016/j.immuni.2006.08.007 · Cited by 1,194 · see citing works
Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases
Gilliet, M., Cao, W., & Liu, Y.-J. (2008) · Nature Reviews Immunology · doi:10.1038/nri2358 · Cited by 1,190 · see citing works
RNA Polymerase III Detects Cytosolic DNA and Induces Type I Interferons through the RIG-I Pathway
Chiu, Y., MacMillan, J. B., & Chen, Z. J. (2009) · Cell · doi:10.1016/j.cell.2009.06.015 · Cited by 1,185 · see citing works
Hayden, M. S., West, A. P., & Ghosh, S. (2006) · Oncogene · doi:10.1038/sj.onc.1209943 · Cited by 1,178 · see citing works
Innate Immune Sensing and Signaling of Cytosolic Nucleic Acids
Wu, J., & Chen, Z. J. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120156 · Cited by 1,179 · see citing works
Toll-like receptors and innate immunity
Kumar, H., Kawai, T., & Akira, S. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.08.062 · Cited by 1,171 · see citing works
Self-citationGitlin, L., Barchet, W., Gilfillan, S., Cella, M., Beutler, B., Flavell, R. A., Diamond, M., & Colonna, M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603082103 · Cited by 1,156 · see citing works
Hayden, M. S., & Ghosh, S. (2011) · Cell Research · doi:10.1038/cr.2011.13 · Cited by 1,120 · see citing works
Distinct RIG-I and MDA5 Signaling by RNA Viruses in Innate Immunity
Loo, Y.-M., Fornek, J., Crochet, N., Bajwa, G., Perwitasari, O., Martinez-Sobrido, L., Akira, S., Gill, M. A., García-Sastre, A., Katze, M. G., et al. (2008) · Journal of Virology · doi:10.1128/jvi.01080-07 · Cited by 1,071 · see citing works
Self-citationNecroptosis in development, inflammation and disease
Weinlich, R., Oberst, A., Beere, H. M., & Green, D. R. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.149 · Cited by 1,016 · see citing works
Recognition of Cytosolic DNA Activates an IRF3-Dependent Innate Immune Response
Stetson, D. B., & Medzhitov, R. M. (2006) · Immunity · doi:10.1016/j.immuni.2005.12.003 · Cited by 1,003 · see citing works
Toll‐like Receptor and RIG‐1‐like Receptor Signaling
Kawai, T., & Akira, S. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1443.020 · Cited by 985 · see citing works
Self-citationActivation and evasion of type I interferon responses by SARS-CoV-2
Lei, X., Dong, X., Ma, R., Wang, W., Xiao, X., Tian, Z., Wang, C., Wang, Y., Li, L., Ren, L., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17665-9 · Cited by 980 · see citing works
Programming the magnitude and persistence of antibody responses with innate immunity
Kasturi, S. P., Skountzou, I., Albrecht, R. A., Koutsonanos, D., Tang, H., Nakaya, H. I., Ravindran, R., Stewart, S. M., Alam, M. S., Kwissa, M., et al. (2011) · Nature · doi:10.1038/nature09737 · Cited by 970 · see citing works
Mitochondria in the Regulation of Innate and Adaptive Immunity
Weinberg, S. E., Sena, L. A., & Chandel, N. S. (2015) · Immunity · doi:10.1016/j.immuni.2015.02.002 · Cited by 960 · see citing works
Type I Interferon Inhibits Interleukin-1 Production and Inflammasome Activation
Guarda, G., Braun, M., Staehli, F., Tardivel, A., Mattmann, C., Förster, I., Farlik, M., Decker, T., Pasquier, R. D., Romero, P. J., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.02.006 · Cited by 924 · see citing works
Ablasser, A., Bauernfeind, F. G., Hartmann, G., Latz, E., Fitzgerald, K. A., & Hornung, V. (2009) · Nature Immunology · doi:10.1038/ni.1779 · Cited by 892 · see citing works
Type 1 Interferons and the Virus-Host Relationship: A Lesson in Detente
García‐Sastre, A., & Biron, C. A. (2006) · Science · doi:10.1126/science.1125676 · Cited by 880 · see citing works
Gack, M. U., Albrecht, R. A., Urano, T., Inn, K., Huang, I., Carnero, E., Farzan, M., Inoue, S., Jung, J. U., & García‐Sastre, A. (2009) · Cell Host & Microbe · doi:10.1016/j.chom.2009.04.006 · Cited by 872 · see citing works
Sun, W., Li, Y., Chen, L., Chen, H., You, F., Zhou, X., Zhou, Y., Zhai, Z., Chen, D., & Jiang, Z. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900850106 · Cited by 862 · see citing works
Li, X.-D., Sun, L., Seth, R. B., Pineda, G., & Chen, Z. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508531102 · Cited by 842 · see citing works
Pernas, L. F., & Scorrano, L. (2015) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-105011 · Cited by 814 · see citing works
A Toll-like receptor–independent antiviral response induced by double-stranded B-form DNA
Ishii, K. J., Coban, C., Kato, H., Takahashi, K., Torii, Y., Takeshita, F., Ludwig, H., Sutter, G., Suzuki, K., Hemmi, H., et al. (2005) · Nature Immunology · doi:10.1038/ni1282 · Cited by 771 · see citing works
Self-citationSignaling Pathways Downstream of Pattern-Recognition Receptors and Their Cross Talk
Lee, M. S., & Kim, Y. (2007) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.76.060605.122847 · Cited by 756 · see citing works
Thomas, P. G., Dash, P., Aldridge, J. R., Ellebedy, A. H., Reynolds, C., Funk, A. J., Martin, W. J., Lamkanfi, M., Webby, R. J., Boyd, K. L., et al. (2009) · Immunity · doi:10.1016/j.immuni.2009.02.006 · Cited by 749 · see citing works
Viral evasion and subversion of pattern-recognition receptor signalling
Bowie, A., & Unterholzner, L. (2008) · Nature reviews. Immunology · doi:10.1038/nri2436 · Cited by 746 · see citing works
Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2
Saito, T., Hirai, R., Loo, Y., Owen, D. M., Johnson, C., Sinha, S. C., Akira, S., Fujita, T., & Gale, M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606699104 · Cited by 743 · see citing works
Self-citationToll‐like receptors and adaptor molecules in liver disease: Update†
Seki, E., & Brenner, D. A. (2008) · Hepatology · doi:10.1002/hep.22306 · Cited by 722 · see citing works
Recognition and Signaling by Toll-Like Receptors
West, A. P., Koblansky, A. A., & Ghosh, S. (2006) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.21.122303.115827 · Cited by 718 · see citing works
LSD1 Ablation Stimulates Anti-tumor Immunity and Enables Checkpoint Blockade
Sheng, W., LaFleur, M. W., Nguyen, T. H., Chen, S., Chakravarthy, A., Conway, J. R., Li, Y., Chen, H., Yang, H., Hsu, P.-H., et al. (2018) · Cell · doi:10.1016/j.cell.2018.05.052 · Cited by 693 · see citing works
LGP2 is a positive regulator of RIG-I– and MDA5-mediated antiviral responses
Satoh, T., Kato, H., Kumagai, Y., Yoneyama, M., Sato, S., Matsushita, K., Tsujimura, T., Fujita, T., Akira, S., & Takeuchi, O. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912986107 · Cited by 697 · see citing works
Self-citationPichlmair, A., & Sousa, C. R. E. (2007) · Immunity · doi:10.1016/j.immuni.2007.08.012 · Cited by 690 · see citing works
Structural Basis for the Activation of Innate Immune Pattern-Recognition Receptor RIG-I by Viral RNA
Kowalinski, E., Lunardi, T., McCarthy, A. A., Louber, J., Brunel, J., Grigorov, B., Gerlier, D., & Cusack, S. (2011) · Cell · doi:10.1016/j.cell.2011.09.039 · Cited by 689 · see citing works
The interferon response circuit: Induction and suppression by pathogenic viruses
Haller, O., Kochs, G., & Weber, F. (2005) · Virology · doi:10.1016/j.virol.2005.09.024 · Cited by 679 · see citing works
The Adaptor MAVS Promotes NLRP3 Mitochondrial Localization and Inflammasome Activation
Subramanian, N., Natarajan, K., Clatworthy, M. R., Wang, Z., & Germain, R. N. (2013) · Cell · doi:10.1016/j.cell.2013.02.054 · Cited by 675 · see citing works
Small self-RNA generated by RNase L amplifies antiviral innate immunity
Malathi, K., Dong, B., Gale, M., & Silverman, R. H. (2007) · Nature · doi:10.1038/nature06042 · Cited by 636 · see citing works
Mitochondria in health, disease, and aging
Harrington, J. S., Ryter, S. W., Plataki, M. E., Price, D. R., & Choi, A. M. K. (2023) · Physiological Reviews · doi:10.1152/physrev.00058.2021 · Cited by 622 · see citing works
Zeng, W., Sun, L., Jiang, X., Chen, X., Hou, F., Adhikari, A., Xu, M., & Chen, Z. J. (2010) · Cell · doi:10.1016/j.cell.2010.03.029 · Cited by 613 · see citing works
Jensen, S., & Thomsen, A. R. (2012) · Journal of Virology · doi:10.1128/jvi.05738-11 · Cited by 604 · see citing works
The Specific and Essential Role of MAVS in Antiviral Innate Immune Responses
Sun, Q., Sun, L., Liu, H.-H., Chen, X., Seth, R. B., Forman, J., & Chen, Z. J. (2006) · Immunity · doi:10.1016/j.immuni.2006.04.004 · Cited by 604 · see citing works
RNA recognition and signal transduction by RIG‐I‐like receptors
Yoneyama, M., & Fujita, T. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00727.x · Cited by 594 · see citing works
IRF7: activation, regulation, modification and function
Ning, S., Pagano, J. S., & Barber, G. N. (2011) · Genes and Immunity · doi:10.1038/gene.2011.21 · Cited by 590 · see citing works
Tetherin Inhibits HIV-1 Release by Directly Tethering Virions to Cells
Pérez-Caballero, D., Zang, T. M., Ebrahimi, A., McNatt, M. W., Gregory, D. A., Johnson, M. C., & Bieniasz, P. D. (2009) · Cell · doi:10.1016/j.cell.2009.08.039 · Cited by 590 · see citing works
NLRX1 is a regulator of mitochondrial antiviral immunity
Moore, C. B., Bergstralh, D. T., Duncan, J. A., Lei, Y. L., Morrison, T. E., Zimmermann, A. G., Accavitti-Loper, M. A., Madden, V. J., Sun, L., Ye, Z., et al. (2008) · Nature · doi:10.1038/nature06501 · Cited by 586 · see citing works
Interferon signalling network in innate defence
Takaoka, A., & Yanai, H. (2006) · Cellular Microbiology · doi:10.1111/j.1462-5822.2006.00716.x · Cited by 586 · see citing works
Pathogen recognition in the innate immune response
Kumar, H., Kawai, T., & Akira, S. (2009) · Biochemical Journal · doi:10.1042/bj20090272 · Cited by 586 · see citing works
Self-citationRIG-I detects viral genomic RNA during negative-strand RNA virus infection
Rehwinkel, J., Tan, C. P., Goubau, D., Schulz, O., Pichlmair, A., Bier, K., Robb, N., Vreede, F., Barclay, W., Fodor, E., et al. (2010) · Cell · doi:10.1016/j.cell.2010.01.020 · Cited by 585 · see citing works
Nucleic acid recognition by the innate immune system
Barbalat, R., Ewald, S. E., Mouchess, M. L., & Barton, G. M. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101340 · Cited by 577 · see citing works
Mibayashi, M., Martínez‐Sobrido, L., Loo, Y., Cardenas, W. B., Gale, M., & García‐Sastre, A. (2006) · Journal of Virology · doi:10.1128/jvi.01265-06 · Cited by 574 · see citing works
Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling
Tal, M. C., Sasai, M., Lee, H. K., Yordy, B., Shadel, G. S., & Iwasaki, A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807694106 · Cited by 573 · see citing works
MDA5/RIG-I and virus recognition
Takeuchi, O., & Akira, S. (2008) · Current Opinion in Immunology · doi:10.1016/j.coi.2008.01.002 · Cited by 567 · see citing works
Self-citationThe Atg5–Atg12 conjugate associates with innate antiviral immune responses
Jounai, N., Takeshita, F., Kobiyama, K., Sakaue-Sawano, A., Miyawaki, A., Xin, K.-Q., Ishii, K. J., Kawai, T., Akira, S., Suzuki, K., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704014104 · Cited by 562 · see citing works
Self-citationYan, N., & Chen, Z. J. (2012) · Nature Immunology · doi:10.1038/ni.2229 · Cited by 535 · see citing works
RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis
Dannappel, M., Vlantis, K., Kumari, S., Polykratis, A., Kim, C., Wachsmuth, L., Eftychi, C., Lin, J., Corona, T., Hermance, N., et al. (2014) · Nature · doi:10.1038/nature13608 · Cited by 534 · see citing works
The Death Domain Superfamily in Intracellular Signaling of Apoptosis and Inflammation
Park, H. H., Lo, Y.-C., Lin, S., Wang, L., Yang, J. K., & Wu, H. (2007) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141656 · Cited by 523 · see citing works
Yan, N., Regalado-Magdos, A. D., Stiggelbout, B., Lee‐Kirsch, M. A., & Lieberman, J. (2010) · Nature Immunology · doi:10.1038/ni.1941 · Cited by 522 · see citing works
Poeck, H., Bscheider, M., Groß, O., Finger, K., Roth, S., Rebsamen, M., Hannesschläger, N., Schlee, M., Rothenfußer, S., Barchet, W., et al. (2009) · Nature Immunology · doi:10.1038/ni.1824 · Cited by 518 · see citing works
Self-citationReactive Oxygen Species in the Immune System
Yang, Y., Bazhin, A. V., Werner, J., & Karakhanova, S. (2013) · International Reviews of Immunology · doi:10.3109/08830185.2012.755176 · Cited by 508 · see citing works
Essential role of IPS-1 in innate immune responses against RNA viruses
Kumar, H., Kawai, T., Kato, H., Sato, S., Takahashi, K., Coban, C., Yamamoto, M., Uematsu, S., Ishii, K. J., Takeuchi, O., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20060792 · Cited by 503 · see citing works
Self-citationTCR–peptide–MHC interactions in situ show accelerated kinetics and increased affinity
Huppa, J. B., Axmann, M., Moertelmaier, M., Lillemeier, B. F., Newell, E. W., Brameshuber, M. O., Klein, L. O., Schütz, G. J., & Davis, M. M. (2010) · Nature · doi:10.1038/nature08746 · Cited by 498 · see citing works
The C-Terminal Regulatory Domain Is the RNA 5′-Triphosphate Sensor of RIG-I
Cui, S., Eisenächer, K., Kirchhofer, A., Brzózka, K. D., Lammens, A., Lammens, K., Fujita, T., Conzelmann, K., Krug, A., & Hopfner, K. (2008) · Molecular Cell · doi:10.1016/j.molcel.2007.10.032 · Cited by 495 · see citing works
Antiviral innate immunity pathways
Seth, R. B., Sun, L., & Chen, Z. J. (2006) · Cell Research · doi:10.1038/sj.cr.7310019 · Cited by 492 · see citing works
The Ubiquitin Ligase TRIM56 Regulates Innate Immune Responses to Intracellular Double-Stranded DNA
Tsuchida, T., Zou, J. P., Saitoh, T., Kumar, H., Abe, T., Matsuura, Y., Kawai, T., & Akira, S. (2010) · Immunity · doi:10.1016/j.immuni.2010.10.013 · Cited by 488 · see citing works
Self-citationUbiquitin signaling in immune responses
Hu, H., & Sun, S. (2016) · Cell Research · doi:10.1038/cr.2016.40 · Cited by 481 · see citing works
Zhong, B., Zhang, L., Lei, C., Li, Y., Mao, A., Yang, Y. F., Wang, Y., Zhang, X., & Shu, H. (2009) · Immunity · doi:10.1016/j.immuni.2009.01.008 · Cited by 478 · see citing works
Hendra and Nipah viruses: different and dangerous
Eaton, B. T., Broder, C. C., Middleton, D., & Wang, L. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1323 · Cited by 477 · see citing works
Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125
Arimoto, K., Takahashi, H., Hishiki, T., Konishi, H., Fujita, T., & Shimotohno, K. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611551104 · Cited by 472 · see citing works
RIP1, a kinase on the crossroads of a cell's decision to live or die
Festjens, N., Berghe, T. V., Cornelis, S., & Vandenabeele, P. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402085 · Cited by 467 · see citing works
Innate immune response to viral infection
Koyama, S., Ishii, K. J., Coban, C., & Akira, S. (2008) · Cytokine · doi:10.1016/j.cyto.2008.07.009 · Cited by 462 · see citing works
Self-citation
- Authors
- Kawai, T., Takahashi, K., Sato, S., Coban, C., Kumar, H., Kato, H., Ishii, K. J., Takeuchi, O., & Akira, S.
- Affiliations
- Japan Science and Technology Agency (JP)
- Kyoto University (JP)
- Research Institute for Microbial Diseases, The University of Osaka (JP)
- Corresponding author
- Akira, Shizuo
- ORCID
- Venue
- Nature Immunology
- Published
- 2005-08-28
- Volume
- 6
- Issue
- 10
- Pages
- 981-988
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W2137303998
- Cited by
- 2,562
- References
- 39
- Citations by year
- 2026: 56 · 2025: 76 · 2024: 79 · 2023: 83 · 2022: 100 · 2021: 114 · 2020: 135 · 2019: 131 · 2018: 120 · 2017: 120 · 2016: 110 · 2015: 132 · 2014: 163 · 2013: 149 · 2012: 152
- FWCI
- 43.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
- Keywords
- IPS-1, type I interferon induction, RIG-I, MDA5, IRF3, IRF7, NF-κB, TBK1, IKKi, antiviral innate immunity, interferon-stimulated genes, viral sensing
- MeSH terms
- DEAD Box Protein 58, Interferon-Induced Helicase, IFIH1, Amino Acid Sequence, Animals, Cells, Cultured, DNA-Binding Proteins, Humans, Interferon Inducers, Interferon Type I, Molecular Sequence Data, Receptors, Immunologic, RNA, Messenger, Transcription Factors, Vesicular stomatitis Indiana virus, NF-kappa B, Sequence Alignment, Interferon-beta, Protein Serine-Threonine Kinases, Protein Structure, Tertiary, RNA Helicases, Adaptor Proteins, Signal Transducing, Interferon Regulatory Factor-3, Interferon Regulatory Factor-7, Mice, I-kappa B Kinase, DEAD-box RNA Helicases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review